YBX1 and VPS35

Number of citations of the paper that reports this interaction (PubMedID 33305682)
68

Data Source:
BioGRID (unspecified method)

		YBX1	VPS35
Description		Y-box binding protein 1	VPS35 retromer complex component
Image
GO Annotations	Cellular Component	P-body Extracellular Region Nucleus Nucleoplasm U12-type Spliceosomal Complex Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cytoplasmic Stress Granule Synapse Extracellular Exosome CRD-mediated MRNA Stability Complex Histone Pre-mRNA 3'end Processing Complex Ribonucleoprotein Complex	Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Postsynaptic Density Membrane Retromer Complex Retromer, Cargo-selective Complex Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Tubular Endosome Dopaminergic Synapse Presynapse Postsynapse Glutamatergic Synapse Mitochondrion-derived Vesicle
	Molecular Function	Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding MiRNA Binding GTPase Binding C5-methylcytidine-containing RNA Reader Activity Sequence-specific Double-stranded DNA Binding	Protein Binding D1 Dopamine Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription MRNA Processing RNA Splicing Epidermis Development Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Embryonic Morphogenesis RNA Transport TRNA Transport Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division CRD-mediated MRNA Stabilization Cellular Response To Interleukin-7 Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Protein Localization To Cytoplasmic Stress Granule MiRNA Transport Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Cellular Senescence	Intracellular Protein Transport Lysosome Organization Positive Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Protein Transport Wnt Signaling Pathway Regulation Of Macroautophagy Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Negative Regulation Of Protein Homooligomerization Protein Localization To Organelle Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Regulation Of Protein Catabolic Process Mitochondrial Fragmentation Involved In Apoptotic Process Transcytosis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Voluntary Musculoskeletal Movement Regulation Of Transport Regulation Of Protein Metabolic Process Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Wnt Protein Secretion Regulation Of Synapse Maturation Positive Regulation Of Mitochondrial Fission Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Locomotion Involved In Locomotory Behavior Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Of Postsynapse Organization Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Regulation Of Postsynapse Assembly Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Dendritic Spine Maintenance Positive Regulation Of Dopamine Biosynthetic Process Negative Regulation Of Protein Localization Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Presynapse Assembly Regulation Of Terminal Button Organization
Pathways		SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA Interferon gamma signaling Noncanonical activation of NOTCH3	WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS
Interacting Genes		125 interacting genes: ACTA2 AKT1 ANKRD2 APBB1 CALM1 CASP8 CEBPA CSNK2A1 CTCF DANCR DUX4 FBXO33 FMR1 FUS GSK3B HABP4 HLA-C HNRNPD HNRNPK HOXC-AS3 IL7R IREB2 IRF1 JAM2 LCP2 LSM3 MAPK1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC MYCN NEIL3 NFYB OGT PCBP2 PCNA PFKFB4 PRPF40A PURA RBBP6 RNF10 RPS6KA1 RPS6KA3 SLC6A4 SMAD3 SMU1 SREK1 SRSF9 TFAP2A TP53 TRAF6 VEGFA VPS35 WEE2-AS1 ZBTB7A	15 interacting genes: APP DRD1 FILNC1 GNL1 LINC01554 MTNR1B PRPF19 SLC11A2 SNX1 USP7 VEGFA VPS26B VPS29 YBX1 ZNF512B
Entrez ID		4904	55737
HPRD ID		01095	06085
Ensembl ID		ENSG00000065978	ENSG00000069329
Uniprot IDs		P67809	Q96QK1
PDB IDs		1H95 5YTS 5YTT 5YTV 5YTX 6A6L 6KTC 6KUG 6LMR 6LMS	2R17 5F0J 5F0K 5F0L 5F0M 5F0P 5OSH 5OSI 7BLN 7BLO 8R02 8R0J 8RKS
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Extracellular Vesicle Regulation Of Metabolic Process Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Developmental Process Regulation Of MRNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Angiogenesis Regulation Of Developmental Process Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cell Motility Regulation Of Protein Metabolic Process	Negative Regulation Of MiRNA Transcription Retromer Complex Retromer, Cargo-selective Complex Early Endosome Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Retrograde Transport, Endosome To Golgi Mating Behavior Cellular Response To Catecholamine Stimulus Regulation Of Neurotransmitter Uptake Response To Catecholamine Insulin Receptor Binding Cytosolic Transport Positive Regulation Of Receptor Internalization Blood Vessel Diameter Maintenance Regulation Of Tube Size Late Endosome Endosome Chemoattractant Activity Reproductive Behavior Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Early Endosome Membrane Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Chemotaxis Regulation Of Protein Localization Nickel Cation Transmembrane Transporter Activity Nickel Cation Transmembrane Transport Vanadium Ion Transport Paraferritin Complex Lead Ion Transport Chromium Ion Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Vanadium Ion Transmembrane Transporter Activity VEGF-A Complex Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Basophil Chemotaxis Visual Learning Positive Regulation Of Receptor-mediated Endocytosis Vasodilation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Protein Transport Acetylcholine Receptor Activator Activity Cell Projection Morphogenesis Myeloid Cell Development Visual Behavior Learning Or Memory Platelet Alpha Granule Lumen
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