YBX1 and IREB2

Number of citations of the paper that reports this interaction (PubMedID 12192037)
43

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		YBX1	IREB2
Description		Y-box binding protein 1	iron responsive element binding protein 2
Image
GO Annotations	Cellular Component	P-body Extracellular Region Nucleus Nucleoplasm U12-type Spliceosomal Complex Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cytoplasmic Stress Granule Synapse Extracellular Exosome CRD-mediated MRNA Stability Complex Histone Pre-mRNA 3'end Processing Complex Ribonucleoprotein Complex	Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding MiRNA Binding GTPase Binding C5-methylcytidine-containing RNA Reader Activity Sequence-specific Double-stranded DNA Binding	MRNA Regulatory Element Binding Translation Repressor Activity RNA Binding Aconitate Hydratase Activity Protein Binding Iron-responsive Element Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription MRNA Processing RNA Splicing Epidermis Development Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Embryonic Morphogenesis RNA Transport TRNA Transport Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division CRD-mediated MRNA Stabilization Cellular Response To Interleukin-7 Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Protein Localization To Cytoplasmic Stress Granule MiRNA Transport Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Cellular Senescence	Regulation Of Translation Protoporphyrinogen IX Biosynthetic Process Intracellular Iron Ion Homeostasis Post-embryonic Development Regulation Of Gene Expression Negative Regulation Of Translation Osteoclast Differentiation Erythrocyte Homeostasis MRNA Stabilization Intestinal Absorption Multicellular Organismal-level Iron Ion Homeostasis
Pathways		SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA Interferon gamma signaling Noncanonical activation of NOTCH3	Iron uptake and transport
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Chronic obstructive pulmonary disease ( 22080838 20173748 25241909) Current cigarettes per day in chronic obstructive pulmonary disease ( 29767774) Diffusing capacity of carbon monoxide ( 30694715) Emotional recognition ( 31596458) Emphysema distribution in smoking ( 27669027) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary artery enlargement in chronic obstructive pulmonary disease ( 25101718) Schizophrenia ( 29483656 25056061)
Interacting Genes		125 interacting genes: ACTA2 AKT1 ANKRD2 APBB1 CALM1 CASP8 CEBPA CSNK2A1 CTCF DANCR DUX4 FBXO33 FMR1 FUS GSK3B HABP4 HLA-C HNRNPD HNRNPK HOXC-AS3 IL7R IREB2 IRF1 JAM2 LCP2 LSM3 MAPK1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC MYCN NEIL3 NFYB OGT PCBP2 PCNA PFKFB4 PRPF40A PURA RBBP6 RNF10 RPS6KA1 RPS6KA3 SLC6A4 SMAD3 SMU1 SREK1 SRSF9 TFAP2A TP53 TRAF6 VEGFA VPS35 WEE2-AS1 ZBTB7A	6 interacting genes: APP OTUD3 RBCK1 TERT USP53 YBX1
Entrez ID		4904	3658
HPRD ID		01095	08858
Ensembl ID		ENSG00000065978	ENSG00000136381
Uniprot IDs		P67809	P48200
PDB IDs		1H95 5YTS 5YTT 5YTV 5YTX 6A6L 6KTC 6KUG 6LMR 6LMS	6VCD
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Extracellular Vesicle Regulation Of Metabolic Process Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Developmental Process Regulation Of MRNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Angiogenesis Regulation Of Developmental Process Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cell Motility Regulation Of Protein Metabolic Process	Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Auditory Stimulus Negative Regulation Of Cellular Senescence Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Senescence TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Biological Quality Cysteine-type Deubiquitinase Activity Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Macromolecule Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization MiRNA Transport RNA-directed RNA Polymerase Activity RNA-templated Transcription Positive Regulation Of Hair Cycle RNA-directed DNA Polymerase Activity Telomerase Catalytic Core Complex Protein K6-linked Deubiquitination Protein Deubiquitination Protein Modification By Small Protein Removal Outer Hair Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway
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