YBX1 and IREB2

Number of citations of the paper that reports this interaction (PMID 12192037)
13

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		YBX1	IREB2
Gene Name		Y box binding protein 1	iron-responsive element binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm U12-type Spliceosomal Complex Cytoplasm Cytoplasmic Stress Granule Ribonucleoprotein Complex Nuclear Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome CRD-mediated MRNA Stability Complex Histone Pre-mRNA 3'end Processing Complex	Cytoplasm Mitochondrion Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Protein Binding Poly(A) RNA Binding	RNA Binding Protein Binding Iron-responsive Element Binding Translation Repressor Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MRNA Splicing, Via Spliceosome In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Splicing Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division CRD-mediated MRNA Stabilization	Protoporphyrinogen IX Biosynthetic Process Iron Ion Transport Cellular Iron Ion Homeostasis Aging Post-embryonic Development Response To Iron(II) Ion Negative Regulation Of Translation Osteoclast Differentiation Response To Retinoic Acid Erythrocyte Homeostasis Intestinal Absorption Cellular Response To Hypoxia
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease ( 22080838 20173748) Obesity-related traits ( 23251661)
Protein-Protein Interactions		41 interactors: ACTA2 AKT1 ANKRD2 APBB1 CALM1 CSNK2A1 CTCF FBXO33 FMR1 FUS GSK3B HABP4 HIST1H1C HLA-C HNRNPD HNRNPK IL7R IREB2 IRF1 JAM2 LCP2 LSM3 MAPK1 NFYB PCBP2 PCNA PRPF40A PURA RBBP6 RPS6KA1 RPS6KA3 SLC6A4 SMAD3 SMU1 SREK1 SRSF9 TFAP2A TP53 TRAF6 UBC VEGFA	5 interactors: APP RBCK1 TERT USP53 YBX1
Entrez ID		4904	3658
HPRD ID		01095	08858
Ensembl ID		ENSG00000065978	ENSG00000136381
Uniprot IDs		P67809	D3DW85 P48200
PDB IDs		1H95
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Immune Response Immune Response Regulation Of Immune System Process Negative Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process Immune System Process Response To Stress Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Apoptotic Process Neurotrophin Signaling Pathway Innate Immune Response RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Growth Programmed Cell Death Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Cell Activation Regulation Of Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Regulation Of Cell Differentiation System Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Translation Negative Regulation Of Biosynthetic Process Gene Expression Blood Coagulation Hemostasis Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Wound Healing Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Growth Regulation Of RNA Metabolic Process Regulation Of Growth Posttranscriptional Regulation Of Gene Expression	Posttranscriptional Regulation Of Gene Expression RNA Processing Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of RNA Interference Transcription, RNA-templated Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Age-dependent Telomere Shortening Protein Linear Polyubiquitination Telomere Formation Via Telomerase Regulation Of Extrinsic Apoptotic Signaling Pathway Telomere Maintenance Via Telomere Shortening Collateral Sprouting Axon Midline Choice Point Recognition CRD-mediated MRNA Stabilization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Telomere Assembly Neuron Remodeling Replicative Cell Aging Telomere Maintenance Via Telomerase Production Of SiRNA Involved In RNA Interference Positive Regulation Of Gene Expression Negative Regulation Of Necroptotic Process MRNA Processing RNA Interference Negative Regulation Of Necrotic Cell Death Replicative Senescence Regulation Of Necroptotic Process Cellular Copper Ion Homeostasis Negative Regulation Of Striated Muscle Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process RNA-dependent DNA Replication Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Gene Silencing Copper Ion Homeostasis Suckling Behavior MRNA Metabolic Process Regulation Of Necrotic Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Cellular Protein Catabolic Process MRNA Stabilization Negative Regulation Of Cellular Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Catabolic Process
Tagcloud ?		annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 xrcc5 yy1 zfhx3 zfp36 zmat3
Tagcloud (Difference) ?		annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 xrcc5 yy1 zfhx3 zfp36 zmat3
Tagcloud (Intersection) ?