ATP2A2 and FGL2

Data Source: HiPPIP (Novel)

		ATP2A2	FGL2
Name		ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	fibrinogen like 2
Structure			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Intercalated Disc Longitudinal Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Calcium Ion-transporting ATPase Complex Ribbon Synapse	Extracellular Region Fibrinogen Complex Extracellular Space Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Calcium Channel Regulator Activity P-type Calcium Transporter Activity Calcium Ion Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Transmembrane Transporter Binding S100 Protein Binding Metal Ion Binding P-type Calcium Transporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential LncRNA Binding	Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Autophagosome Assembly Regulation Of The Force Of Heart Contraction Muscle System Process Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Muscle Contraction ER-nucleus Signaling Pathway Cell Adhesion Epidermis Development Positive Regulation Of Heart Rate Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Autophagosome Membrane Docking Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration T-tubule Organization Monoatomic Ion Transmembrane Transport Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Negative Regulation Of Heart Contraction Relaxation Of Cardiac Muscle Neuron Cellular Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Organelle Localization By Membrane Tethering Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Cardiac Conduction Calcium Ion Import Into Sarcoplasmic Reticulum Mitochondrion-endoplasmic Reticulum Membrane Tethering	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Macrophage Antigen Processing And Presentation Negative Regulation Of Memory T Cell Differentiation Negative Regulation Of Defense Response To Virus
Pathways		Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	Neutrophil degranulation
Drugs		Ritodrine Desflurane Sevoflurane Istaroxime	None
Diseases		Acrokeratosis verruciformis Darier disease; Dyskeratosis follicularis	None
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Glucose homeostasis traits ( 25524916 ) Protein quantitative trait loci ( 18464913 ) QT interval ( 24952745 29874175 ) Schizophrenia ( 25056061 28991256 29483656 30285260 ) Waist circumference ( 28552196 )	Crohn's disease ( 30500874 )
Novel Interactors		3 novel interactors: FGL2 SMCO4 UNG	1 novel interactors: ATP2A2
Interacting Genes		20 interacting genes: ARLN BCL2 CAMK2A CCR4 CEBPA CHRM5 ELN F2RL1 FILNC1 HGS IRS1 IRS2 MDM2 PLN S100A1 SPP1 SRI TNFAIP3 TRIM14 TTC3	1 interacting genes: CFTR
Entrez ID		488	10875
HPRD ID		00161	16098
Ensembl ID		ENSG00000174437	ENSG00000127951
Uniprot IDs		A0A0S2Z3L2 P16615	A4D1B8 Q14314
PDB IDs		5ZTF 6JJU 6LLE 6LLY 6LN5 6LN6 6LN7 6LN8 6LN9 7BT2 7E7S 7W7T 7W7U 7W7V 7W7W	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Multicellular Organismal Process Response To Hormone Protease Binding Positive Regulation Of Transport Regulation Of Secretion Regulation Of Secretion By Cell Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Transport Regulation Of Hormone Secretion Regulation Of Biological Quality Signal Transduction Response To Lipid Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Insulin Secretion Regulation Of System Process Negative Regulation Of B Cell Apoptotic Process Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Response To Vitamin Regulation Of Peptide Hormone Secretion Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Fatty Acid Oxidation Regulation Of Heart Contraction Sarcoplasmic Reticulum Negative Regulation Of Heart Rate Response To Steroid Hormone Regulation Of Calcium Ion Transport Negative Regulation Of Transport Protein Domain Specific Binding Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Positive Regulation Of Glycogen Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Relaxation Of Muscle Regulation Of Protein Transport Tolerance Induction Calcium Ion Transport Response To Hydrogen Peroxide Regulation Of B Cell Apoptotic Process Regulation Of Blood Circulation Ubiquitin Binding Regulation Of Heart Rate Negative Regulation Of Heart Contraction Regulation Of Protein Secretion Insulin Receptor Binding Negative Regulation Of Blood Circulation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Transmembrane Transport Protein Polyubiquitination Regulation Of Cellular Localization	Membrane Docking Organelle Localization By Membrane Tethering P-type Calcium Transporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Exocytosis Longitudinal Sarcoplasmic Reticulum Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Calcium Ion-transporting ATPase Complex Response To Endoplasmic Reticulum Stress Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Positive Regulation Of Anion Channel Activity Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Monoatomic Anion Transport Enzyme Binding Mitochondrion-endoplasmic Reticulum Membrane Tethering Organelle Localization Ribbon Synapse Monoatomic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Membrane Potential Autophagosome Membrane Docking Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter ATP Hydrolysis Activity Transition Between Fast And Slow Fiber Intracellular Monoatomic Cation Homeostasis T-tubule Organization Cytosol To Endoplasmic Reticulum Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Intracellular Chemical Homeostasis P-type Calcium Transporter Activity Platelet Dense Tubular Network Membrane Regulation Of Vesicle-mediated Transport Amelogenesis Regulation Of Secretion By Cell ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Skeletal Muscle Adaptation Regulation Of Secretion