MAML3

Description		mastermind like transcriptional coactivator 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Transcription Coactivator Activity Protein Binding
	Biological Process	Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm
Drugs
Diseases
GWAS		Academic attainment (English) ( 33594131) Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Borderline personality disorder ( 28632202) Chronic mucus hypersecretion ( 25234806) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart malformation ( 23708190) Gastroesophageal reflux disease ( 31527586) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Malaria ( 31844061) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Multisite chronic pain ( 31194737) Smoking initiation ( 33082346) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Walking pace ( 33128006)
Interacting Genes		12 interacting genes: NFX1 NID2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RAI1 SCMH1 SUPT5H VPS26C ZBTB1 ZZZ3
Entrez ID		55534
HPRD ID		10066
Ensembl ID		ENSG00000196782
Uniprot IDs		Q96JK9
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of RNA Metabolic Process Notch Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Tumor Cell Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Differentiation Regulation Of RNA Metabolic Process Luteolysis Atrioventricular Node Development Glomerular Capillary Formation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription Of Notch Receptor Target Nucleoplasm Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Biosynthetic Process Gland Development Signaling Receptor Activity Regulation Of Lymphoid Progenitor Cell Differentiation Calcium Ion Binding Tube Morphogenesis Left/right Axis Specification Pulmonary Valve Morphogenesis Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Ras Protein Signal Transduction Regulation Of Gene Expression Morphogenesis Of An Epithelial Sheet Nephron Tubule Development Regulation Of Macromolecule Biosynthetic Process Notch Binding Negative Regulation Of Metabolic Process Enzyme Binding Regulation Of Primary Metabolic Process Renal Tubule Development Nucleus Regulation Of Muscle Cell Differentiation Endothelial Cell Differentiation Inflammatory Response To Antigenic Stimulus Receptor Complex Positive Regulation Of BMP Signaling Pathway Regulation Of Endothelial Cell Differentiation
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