MAML3 and RAI1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		MAML3	RAI1
Description		mastermind like transcriptional coactivator 3	retinoic acid induced 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Transcription By RNA Polymerase II	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Negative Regulation Of Multicellular Organism Growth Positive Regulation Of DNA-templated Transcription Rhythmic Process
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm	Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs
Diseases			Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
GWAS		Academic attainment (English) ( 33594131) Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Borderline personality disorder ( 28632202) Chronic mucus hypersecretion ( 25234806) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart malformation ( 23708190) Gastroesophageal reflux disease ( 31527586) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Malaria ( 31844061) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Multisite chronic pain ( 31194737) Smoking initiation ( 33082346) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Walking pace ( 33128006)	A body shape index ( 34021172) Body mass index ( 28892062) Caffeine consumption from coffee ( 33287642) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Glycated hemoglobin levels ( 34059833) Hip circumference ( 25673412) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 27863252) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Parkinson's disease ( 21738487) Schizophrenia ( 29483656 28991256 25056061) Type 2 diabetes ( 30054458 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		12 interacting genes: NFX1 NID2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RAI1 SCMH1 SUPT5H VPS26C ZBTB1 ZZZ3	17 interacting genes: CASP2 CDKN1A DDIT3 GADD45A GATA1 GLI1 GSK3B LZTR1 MAML3 MAPK8IP2 PIN1 RPS6KA5 TESC TET2 TOPBP1 TTR ZNF496
Entrez ID		55534	10743
HPRD ID		10066	07406
Ensembl ID		ENSG00000196782	ENSG00000108557
Uniprot IDs		Q96JK9	Q7Z5J4
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of RNA Metabolic Process Notch Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Tumor Cell Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Differentiation Regulation Of RNA Metabolic Process Luteolysis Atrioventricular Node Development Glomerular Capillary Formation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription Of Notch Receptor Target Nucleoplasm Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Biosynthetic Process Gland Development Signaling Receptor Activity Regulation Of Lymphoid Progenitor Cell Differentiation Calcium Ion Binding Tube Morphogenesis Left/right Axis Specification Pulmonary Valve Morphogenesis Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Ras Protein Signal Transduction Regulation Of Gene Expression Morphogenesis Of An Epithelial Sheet Nephron Tubule Development Regulation Of Macromolecule Biosynthetic Process Notch Binding Negative Regulation Of Metabolic Process Enzyme Binding Regulation Of Primary Metabolic Process Renal Tubule Development Nucleus Regulation Of Muscle Cell Differentiation Endothelial Cell Differentiation Inflammatory Response To Antigenic Stimulus Receptor Complex Positive Regulation Of BMP Signaling Pathway Regulation Of Endothelial Cell Differentiation	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Positive Regulation Of RNA Metabolic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Transcription By RNA Polymerase II ER Overload Response RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Apoptotic Signaling Pathway Megakaryocyte Differentiation Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Cycle Regulation Of Canonical Wnt Signaling Pathway Nucleoplasm Regulation Of RNA Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Growth Intracellular Signaling Cassette Regeneration Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Response To Stress Response To Ionizing Radiation Regulation Of JNK Cascade Positive Regulation Of Biosynthetic Process Mitotic G2 DNA Damage Checkpoint Signaling Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Developmental Process ER-nucleus Signaling Pathway Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
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