MAML3 and ZBTB1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		MAML3	ZBTB1
Gene Name		mastermind-like 3 (Drosophila)	zinc finger and BTB domain containing 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Transcription Coactivator Activity	DNA Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of T Cell Mediated Immunity B Cell Differentiation Positive Regulation Of Natural Killer Cell Differentiation T Cell Differentiation In Thymus MRNA Transcription From RNA Polymerase II Promoter Innate Immune Response Positive Regulation Of T Cell Differentiation Thymus Development Protein Homooligomerization Positive Regulation Of Pro-T Cell Differentiation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Notch-HLH transcription pathway Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Congenital heart malformation ( 23708190)
Protein-Protein Interactions		10 interactors: NFX1 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RAI1 SCMH1 SUPT5H ZBTB1 ZZZ3	14 interactors: AR EWSR1 FAM161A LZTR1 MAML3 NDN PCNA PIM1 SUMO2 TRIM42 UBC ZBTB25 ZNF417 ZNF572
Entrez ID		55534	22890
HPRD ID		10066	15688
Ensembl ID		ENSG00000196782	ENSG00000126804
Uniprot IDs		Q96JK9 Q9NPV6	Q9Y2K1
PDB IDs
Enriched GO Terms of Interacting Partners?		Notch Receptor Processing Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Notch Signaling Pathway Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cell Fate Commitment Interleukin-4 Secretion Notch Signaling Involved In Heart Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Pulmonary Valve Morphogenesis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Interleukin-4 Production Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Pattern Specification Process Regulation Of Endothelial Cell Differentiation Glomerulus Vasculature Development Blood Vessel Development Vasculature Development Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Valve Morphogenesis Heart Valve Development Positive Regulation Of BMP Signaling Pathway	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process DNA-templated Transcription, Initiation Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Leading Strand Elongation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Integrin Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Integrin Biosynthetic Process Cellular Metabolic Process Notch Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cell Growth Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Intracellular Receptor Signaling Pathway Mitotic Cell Cycle Process Positive Regulation Of Transcription From RNA Polymerase III Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Translesion Synthesis Viral Protein Processing Positive Regulation Of Protein Catabolic Process Cell Proliferation Neurotrophin Signaling Pathway
Tagcloud ?		2c acetyltransferase activators binds box broadly catenin cdk8 coactivator coactivators connects conserved contains diverse enhancer evolutionarily interact key mads maml1 maml2 mastermind mediator mef molecule notch regulate suppressor
Tagcloud (Difference) ?		2c acetyltransferase activators binds box broadly catenin cdk8 coactivator coactivators connects conserved contains diverse enhancer evolutionarily interact key mads maml1 maml2 mastermind mediator mef molecule notch regulate suppressor
Tagcloud (Intersection) ?