MAML3 and NFX1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		MAML3	NFX1
Description		mastermind like transcriptional coactivator 3	nuclear transcription factor, X-box binding 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Protein Ubiquitination Negative Regulation Of MHC Class II Biosynthetic Process Protein Autoubiquitination
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm
Drugs
Diseases
GWAS		Academic attainment (English) ( 33594131) Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Borderline personality disorder ( 28632202) Chronic mucus hypersecretion ( 25234806) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart malformation ( 23708190) Gastroesophageal reflux disease ( 31527586) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Malaria ( 31844061) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Multisite chronic pain ( 31194737) Smoking initiation ( 33082346) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Walking pace ( 33128006)	Fasting glucose ( 34059833)
Interacting Genes		12 interacting genes: NFX1 NID2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RAI1 SCMH1 SUPT5H VPS26C ZBTB1 ZZZ3	5 interacting genes: ELAVL4 MAML3 UBC UBE2N UBE3A
Entrez ID		55534	4799
HPRD ID		10066	11936
Ensembl ID		ENSG00000196782	ENSG00000086102
Uniprot IDs		Q96JK9	Q12986
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of RNA Metabolic Process Notch Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Tumor Cell Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Differentiation Regulation Of RNA Metabolic Process Luteolysis Atrioventricular Node Development Glomerular Capillary Formation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription Of Notch Receptor Target Nucleoplasm Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Biosynthetic Process Gland Development Signaling Receptor Activity Regulation Of Lymphoid Progenitor Cell Differentiation Calcium Ion Binding Tube Morphogenesis Left/right Axis Specification Pulmonary Valve Morphogenesis Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Ras Protein Signal Transduction Regulation Of Gene Expression Morphogenesis Of An Epithelial Sheet Nephron Tubule Development Regulation Of Macromolecule Biosynthetic Process Notch Binding Negative Regulation Of Metabolic Process Enzyme Binding Regulation Of Primary Metabolic Process Renal Tubule Development Nucleus Regulation Of Muscle Cell Differentiation Endothelial Cell Differentiation Inflammatory Response To Antigenic Stimulus Receptor Complex Positive Regulation Of BMP Signaling Pathway Regulation Of Endothelial Cell Differentiation	Positive Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Protein Polyubiquitination Post-translational Protein Modification Ligase Inhibitor Activity Negative Regulation Of TORC1 Signaling Sperm Entry Positive Regulation Of Golgi Lumen Acidification Protein K63-linked Ubiquitination Positive Regulation Of Protein Modification Process Negative Regulation Of TOR Signaling Pre-mRNA Intronic Pyrimidine-rich Binding Regulation Of TORC1 Signaling Positive Regulation Of Protein Ubiquitination Positive Regulation Of Macrophage Apoptotic Process Apoptotic Process Involved In Mammary Gland Involution UBC13-MMS2 Complex Regulation Of Golgi Lumen Acidification Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Senescence-associated Heterochromatin Focus Growth Cone Modification-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Complex Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of TOR Signaling Positive Regulation Of Cellular PH Reduction Mitochondrial Depolarization Oncogene-induced Cell Senescence Negative Regulation Of Immature T Cell Proliferation Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process RNA Binding Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Localization To Lysosome G Protein-coupled Opioid Receptor Activity Myosin Phosphatase Regulator Activity Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Protein K63-linked Ubiquitination Protein Modification Process Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Myeloid Cell Apoptotic Process
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