MAML3 and NOTCH3

Number of citations of the paper that reports this interaction (PMID 12370315)
33

Data Source:
HPRD (in vivo)

		MAML3	NOTCH3
Gene Name		mastermind-like 3 (Drosophila)	notch 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Golgi Membrane Extracellular Region Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Actin Cytoskeleton Integral Component Of Membrane Receptor Complex
	Molecular Function	Transcription Coactivator Activity	Calcium Ion Binding Protein Binding Enzyme Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Notch Receptor Processing Gene Expression Forebrain Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Glomerular Capillary Formation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Notch-HLH transcription pathway Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Notch-HLH transcription pathway Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing Signaling by NOTCH3
Drugs
Diseases
GWAS		Congenital heart malformation ( 23708190)
Protein-Protein Interactions		10 interactors: NFX1 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RAI1 SCMH1 SUPT5H ZBTB1 ZZZ3	40 interactors: BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B MAML1 MAML2 MAML3 MPPED2 MYC NEDD9 PPIA PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8
Entrez ID		55534	4854
HPRD ID		10066	02607
Ensembl ID		ENSG00000196782	ENSG00000074181
Uniprot IDs		Q96JK9 Q9NPV6	Q9UM47
PDB IDs
Enriched GO Terms of Interacting Partners?		Notch Receptor Processing Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Notch Signaling Pathway Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cell Fate Commitment Interleukin-4 Secretion Notch Signaling Involved In Heart Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Pulmonary Valve Morphogenesis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Interleukin-4 Production Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Pattern Specification Process Regulation Of Endothelial Cell Differentiation Glomerulus Vasculature Development Blood Vessel Development Vasculature Development Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Valve Morphogenesis Heart Valve Development Positive Regulation Of BMP Signaling Pathway	Notch Signaling Pathway Notch Receptor Processing Transcription Initiation From RNA Polymerase II Promoter Tissue Morphogenesis DNA-templated Transcription, Initiation Morphogenesis Of An Epithelium Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Epithelium Development Positive Regulation Of Metabolic Process Immune System Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression System Development Positive Regulation Of Cellular Biosynthetic Process Multicellular Organismal Development Hemopoiesis Cell Surface Receptor Signaling Pathway Anatomical Structure Development Cell Fate Commitment Developmental Process Tube Development Positive Regulation Of Signal Transduction Cell Differentiation Regulation Of Cell Differentiation Organ Morphogenesis Auditory Receptor Cell Differentiation Heart Morphogenesis Epithelial Tube Morphogenesis Membrane Protein Proteolysis Myeloid Leukocyte Differentiation Positive Regulation Of Transcription Of Notch Receptor Target Hair Cell Differentiation Auditory Receptor Cell Fate Commitment Stem Cell Development Tube Morphogenesis Myoblast Differentiation Cell Development Endothelial Tube Morphogenesis Generation Of Neurons Notch Signaling Involved In Heart Development Amyloid Precursor Protein Catabolic Process Nervous System Development Stem Cell Maintenance Negative Regulation Of Cell Differentiation Stem Cell Differentiation Inner Ear Receptor Cell Differentiation
Tagcloud ?		2c acetyltransferase activators binds box broadly catenin cdk8 coactivator coactivators connects conserved contains diverse enhancer evolutionarily interact key mads maml1 maml2 mastermind mediator mef molecule notch regulate suppressor	barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 mastermind metaplasia muc17 muc2 muc3b muc5b mucins organotypic transdifferentiation
Tagcloud (Difference) ?		2c acetyltransferase activators binds box broadly catenin cdk8 coactivator coactivators connects conserved contains diverse enhancer evolutionarily interact key mads maml1 maml2 mediator mef molecule regulate suppressor	barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 metaplasia muc17 muc2 muc3b muc5b mucins organotypic transdifferentiation
Tagcloud (Intersection) ?		mastermind notch