DTX1 and TAX1BP3

Number of citations of the paper that reports this interaction (PubMedID 23395680)
34

Data Source:
BioGRID (fluorescent resonance energy transfer)

		DTX1	TAX1BP3
Description		deltex E3 ubiquitin ligase 1	Tax1 binding protein 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body	Fibrillar Center Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Notch Binding Protein Binding Zinc Ion Binding Transferase Activity SH3 Domain Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Beta-catenin Binding
	Biological Process	DNA-templated Transcription Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Regulation Of Notch Signaling Pathway Glial Cell Differentiation Protein Ubiquitination T Cell Differentiation Negative Regulation Of T Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Cellular Response To Leukemia Inhibitory Factor	Rho Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of Protein Localization To Cell Surface
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus	RHO GTPases Activate Rhotekin and Rhophilins
Drugs
Diseases
GWAS		Body mass index ( 26426971) Coffee consumption ( 29367735) Retinitis pigmentosa ( 33514863) Visceral adipose tissue adjusted for BMI ( 22589738) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: DEFA5 DTX2 DTX3 DTX3L EP300 G3BP1 GRB2 ITCH MAP3K1 NOTCH1 NOTCH2 PRKAR1A TAX1BP3 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N UBE2U	14 interacting genes: ARHGEF16 ARNT2 CDK5RAP3 CTNNB1 DTX1 GATA1 GLS GLS2 PLK4 RNF183 RTKN STAU1 TCEA2 TRIM29
Entrez ID		1840	30851
HPRD ID		03991	18160
Ensembl ID		ENSG00000135144	ENSG00000213977
Uniprot IDs		Q86Y01	A0A087X282 O14907
PDB IDs		6Y5N 6Y5P 8R5N 8R6A 8R6B	2KG2 2L4S 2L4T 2VZ5 3GJ9 3SFJ 4E3B 4NNL 4NNM
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Activity Macromolecule Catabolic Process Protein Metabolic Process Notch Signaling Pathway Catabolic Process Proteolysis Protein Monoubiquitination Nucleotide Binding Protein Autoubiquitination Ubiquitin-like Protein Transferase Activity ATP Binding Intracellular Signal Transduction Ubiquitin-like Protein Ligase Binding Cellular Response To Tumor Cell Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Surface Receptor Signaling Pathway Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of BMP Signaling Pathway Defense Response Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Atrioventricular Node Development Protein-containing Complex Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleoplasm Regulation Of Cellular Response To Growth Factor Stimulus Immune Response Macromolecule Metabolic Process Positive Regulation Of Receptor Catabolic Process Signal Transduction TORC1 Signaling Negative Regulation Of BMP Signaling Pathway STAT Family Protein Binding Regulation Of Protein Ubiquitination Regulation Of Protein Modification Process Innate Immune Response Response To External Biotic Stimulus	L-glutamine Catabolic Process Glutaminase Activity Glutamate Biosynthetic Process Glutamine Metabolic Process Transcription Regulator Complex DNA-templated Transcription Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Centrosome Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Glial Cell Fate Determination Protein-DNA Complex Renal Inner Medulla Development In Utero Embryonic Development Scrib-APC-beta-catenin Complex Regulation Of Apoptotic Process Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Renal Outer Medulla Development Transcription Coregulator Binding Renal Vesicle Formation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Myeloid Cell Differentiation Chordate Embryonic Development Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Regulation Of Glycoprotein Biosynthetic Process Regulation Of Programmed Cell Death Transcription By RNA Polymerase II Basophil Differentiation P53 Binding Eosinophil Fate Commitment Regulation Of Primitive Erythrocyte Differentiation Erythrocyte Differentiation Glutamate Metabolic Process Amino Acid Biosynthetic Process Glutamine Family Amino Acid Metabolic Process Septin Ring Organization Oviduct Development Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mononuclear Cell Differentiation Protein Modification By Small Protein Conjugation Fungiform Papilla Formation Beta-catenin-TCF7L2 Complex Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Centriole-centriole Cohesion Embryonic Skeletal Limb Joint Morphogenesis
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