DTX1 and UBE2C

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		DTX1	UBE2C
Gene Name		deltex 1, E3 ubiquitin ligase	ubiquitin-conjugating enzyme E2C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Notch Binding Protein Binding Zinc Ion Binding Ligase Activity SH3 Domain Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Regulation Of Notch Signaling Pathway Glial Cell Differentiation Protein Ubiquitination Negative Regulation Of T Cell Differentiation Negative Regulation Of Neuron Differentiation Regulation Of Nucleic Acid-templated Transcription	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Exit From Mitosis Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer	Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS		Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		20 interactors: DEFA5 DTX2 DTX3 DTX3L EP300 G3BP1 GRB2 ITCH MAP3K1 NOTCH1 NOTCH2 TAX1BP3 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N UBE2U	20 interactors: ANAPC11 ANAPC2 CDC20 CKAP2 CXCR1 DTX1 ENO2 FZR1 KLHL2 MAPK7 PCGF3 POLM PSMD4 RELA TNNC1 TRIM21 TRIM28 UBA1 UBASH3B UBE3D
Entrez ID		1840	11065
HPRD ID		03991	05717
Ensembl ID		ENSG00000135144	ENSG00000175063
Uniprot IDs		Q86Y01	O00762 Q5TZN3
PDB IDs			1I7K
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Pattern Recognition Receptor Signaling Pathway Notch Signaling Pathway Innate Immune Response-activating Signal Transduction Immune Response Activation Of Innate Immune Response Defense Response Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Response To Hypoxia Protein Catabolic Process Cellular Response To Decreased Oxygen Levels Histone Ubiquitination Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stress Protein Metabolic Process Cellular Response To Stimulus Cellular Macromolecule Catabolic Process Immune System Process Response To Stress Positive Regulation Of Ubiquitin-protein Transferase Activity Response To Stimulus Positive Regulation Of Ligase Activity Positive Regulation Of Immune Response Signal Transduction Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Signaling Proteasomal Protein Catabolic Process Cell Communication Protein K63-linked Ubiquitination Mitotic Spindle Assembly Checkpoint	Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Catabolic Process Cellular Protein Modification Process Protein Polyubiquitination Negative Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Protein Catabolic Process Cell Cycle Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Positive Regulation Of Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Mitotic Spindle Checkpoint Cellular Protein Metabolic Process Negative Regulation Of Chromosome Segregation Negative Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Protein Metabolic Process Activation Of Anaphase-promoting Complex Activity
Tagcloud ?		algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx2 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z	accelerated amplifications cin conferring connection copy core decipher disadvantage drive fitness framework genomes instability intratumor intriguingly landscape logical module permissive permits pressures regulators selection sets signature signatures tpx2 typically
Tagcloud (Difference) ?		algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx2 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z	accelerated amplifications cin conferring connection copy core decipher disadvantage drive fitness framework genomes instability intratumor intriguingly landscape logical module permissive permits pressures regulators selection sets signature signatures tpx2 typically
Tagcloud (Intersection) ?