DTX1 and NOTCH1

Number of citations of the paper that reports this interaction (PMID 11564735)
27

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		DTX1	NOTCH1
Gene Name		deltex 1, E3 ubiquitin ligase	notch 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Golgi Membrane Acrosomal Vesicle MAML1-RBP-Jkappa- ICN1 Complex Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex
	Molecular Function	Transcription Coactivator Activity Notch Binding Protein Binding Zinc Ion Binding Ligase Activity SH3 Domain Binding Ubiquitin Protein Ligase Binding	Core Promoter Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Enzyme Inhibitor Activity Receptor Activity Calcium Ion Binding Protein Binding Enzyme Binding Chromatin DNA Binding Sequence-specific DNA Binding
	Biological Process	Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Regulation Of Notch Signaling Pathway Glial Cell Differentiation Protein Ubiquitination Negative Regulation Of T Cell Differentiation Negative Regulation Of Neuron Differentiation Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Cell Fate Specification Epithelial To Mesenchymal Transition Liver Development Heart Looping Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Inflammatory Response To Antigenic Stimulus Endocardium Development Endocardium Morphogenesis Atrioventricular Node Development Coronary Vein Morphogenesis Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Mitral Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Chamber Formation Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Cardiac Right Atrium Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Formation Ventricular Trabecula Myocardium Morphogenesis Growth Involved In Heart Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Cell Migration Involved In Endocardial Cushion Formation Pericardium Morphogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Immune Response Humoral Immune Response Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Transcription Of Notch Receptor Target Spermatogenesis Determination Of Left/right Symmetry Compartment Pattern Specification Axonogenesis Foregut Morphogenesis Endoderm Development Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Auditory Receptor Cell Fate Commitment Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Myotube Differentiation Mesenchymal Cell Development Regulation Of Somitogenesis Cell Differentiation In Spinal Cord Neural Tube Development Keratinocyte Differentiation Negative Regulation Of Ossification Lung Development Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Hair Follicle Morphogenesis Organ Regeneration Response To Corticosteroid Response To Muramyl Dipeptide Response To Lipopolysaccharide Embryonic Hindlimb Morphogenesis Tube Formation Skeletal Muscle Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Tissue Regeneration Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of JAK-STAT Cascade Negative Regulation Of Photoreceptor Cell Differentiation Somatic Stem Cell Division Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Glial Cell Proliferation Cilium Morphogenesis Cardiac Epithelial To Mesenchymal Transition Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Prostate Gland Epithelium Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Arterial Endothelial Cell Differentiation Venous Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Endocardial Cell Differentiation Vasculogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Notch Signaling Involved In Heart Development Heart Trabecula Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Left/right Axis Specification Cellular Response To Follicle-stimulating Hormone Stimulus Distal Tubule Development Collecting Duct Development Glomerular Mesangial Cell Development Interleukin-4 Secretion Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance Regulation Of Extracellular Matrix Assembly Apoptotic Process Involved In Embryonic Digit Morphogenesis Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Anoikis Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Endothelial Cell Chemotaxis
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer	Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Pre-NOTCH Processing in the Endoplasmic Reticulum Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Regulation of beta-cell development Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FBXW7 Mutants and NOTCH1 in Cancer Pre-NOTCH Processing in Golgi Signaling by NOTCH Notch-HLH transcription pathway Activated NOTCH1 Transmits Signal to the Nucleus NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS		Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		20 interactors: DEFA5 DTX2 DTX3 DTX3L EP300 G3BP1 GRB2 ITCH MAP3K1 NOTCH1 NOTCH2 TAX1BP3 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N UBE2U	56 interactors: ADAM17 AKT1 APBA1 BLOC1S1 CACNA1A CAMK4 CBL CNTN1 CTNNB1 DLL1 DLL4 DTX1 DTX2 EGFL7 EP300 FBXW7 FURIN GFI1B GSK3B ILK ITCH JAG1 JAG2 KAT2A KAT2B LCK LEF1 LFNG MAML1 MAML2 MAML3 MDM2 MEF2C MFNG NFKB1 NOV NUMB NUMBL PIK3CG POFUT1 PSEN1 PSEN2 RBP3 RBPJ REL RELA RUNX3 SMAD3 SNAI1 SNW1 USP12 WDR12 WWP1 XIAP XRCC6 YY1
Entrez ID		1840	4851
HPRD ID		03991	01827
Ensembl ID		ENSG00000135144	ENSG00000148400
Uniprot IDs		Q86Y01	P46531
PDB IDs			1PB5 1TOZ 1YYH 2F8X 2F8Y 2HE0 2VJ3 3ETO 3I08 3L95 3NBN 3V79
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Pattern Recognition Receptor Signaling Pathway Notch Signaling Pathway Innate Immune Response-activating Signal Transduction Immune Response Activation Of Innate Immune Response Defense Response Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Response To Hypoxia Protein Catabolic Process Cellular Response To Decreased Oxygen Levels Histone Ubiquitination Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stress Protein Metabolic Process Cellular Response To Stimulus Cellular Macromolecule Catabolic Process Immune System Process Response To Stress Positive Regulation Of Ubiquitin-protein Transferase Activity Response To Stimulus Positive Regulation Of Ligase Activity Positive Regulation Of Immune Response Signal Transduction Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Signaling Proteasomal Protein Catabolic Process Cell Communication Protein K63-linked Ubiquitination Mitotic Spindle Assembly Checkpoint	Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Signaling Cell Communication Signal Transduction System Development Cellular Response To Stimulus Positive Regulation Of Gene Expression Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Organ Development Regulation Of Signal Transduction Anatomical Structure Development Epithelium Development Regulation Of Signaling Positive Regulation Of Signal Transduction Developmental Process Response To Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Morphogenesis Nervous System Development Regulation Of Cell Differentiation Regulation Of Cell Development Positive Regulation Of Transcription, DNA-templated Pattern Specification Process Cell Differentiation Regulation Of Cell Death Tissue Development Generation Of Neurons Morphogenesis Of An Epithelium Regulation Of Gene Expression Notch Receptor Processing Negative Regulation Of Cell Death Positive Regulation Of Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process Organ Morphogenesis Regulation Of Metabolic Process Neurogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Somitogenesis Regulation Of Neurogenesis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Apoptotic Process
Tagcloud ?		algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx2 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z	a23187 alpha1 antitrypsin biologically carboxyl cleaved convertase convertases decisions dibasic digestion disagree exists extend fate furin heterodimeric invertebrates ionophore lovo nearby pdx processed processing proteolytic rqrr takes vertebrates
Tagcloud (Difference) ?		algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx2 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z	a23187 alpha1 antitrypsin biologically carboxyl cleaved convertase convertases decisions dibasic digestion disagree exists extend fate furin heterodimeric invertebrates ionophore lovo nearby pdx processed processing proteolytic rqrr takes vertebrates
Tagcloud (Intersection) ?