DTX1 and DEFA5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DTX1	DEFA5
Description		deltex E3 ubiquitin ligase 1	defensin alpha 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body	Extracellular Region Extracellular Space Golgi Lumen Transport Vesicle Secretory Granule Midbody Cytoplasmic Vesicle Secretory Granule Lumen
	Molecular Function	Transcription Coactivator Activity Notch Binding Protein Binding Zinc Ion Binding Transferase Activity SH3 Domain Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein Homodimerization Activity Pore-forming Activity
	Biological Process	DNA-templated Transcription Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Regulation Of Notch Signaling Pathway Glial Cell Differentiation Protein Ubiquitination T Cell Differentiation Negative Regulation Of T Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Cellular Response To Leukemia Inhibitory Factor	Immune System Process Defense Response Antibacterial Humoral Response Killing Of Cells Of Another Organism Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Protein Homotetramerization Disruption Of Plasma Membrane Integrity In Another Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Membrane Permeability
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus	Defensins Alpha-defensins Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
GWAS		Body mass index ( 26426971) Coffee consumption ( 29367735) Retinitis pigmentosa ( 33514863) Visceral adipose tissue adjusted for BMI ( 22589738) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Basophil count ( 32888494) Blood protein levels ( 30072576) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 26252872) Mercury levels ( 26025379)
Interacting Genes		21 interacting genes: DEFA5 DTX2 DTX3 DTX3L EP300 G3BP1 GRB2 ITCH MAP3K1 NOTCH1 NOTCH2 PRKAR1A TAX1BP3 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N UBE2U	5 interacting genes: ACE2 BMI1 DTX1 MEOX2 PRSS1
Entrez ID		1840	1670
HPRD ID		03991	02720
Ensembl ID		ENSG00000135144	ENSG00000164816
Uniprot IDs		Q86Y01	Q01523
PDB IDs		6Y5N 6Y5P 8R5N 8R6A 8R6B	1ZMP 2LXZ 2MIT 3I5W 4E82 4E83 4E86 4RBW 4RBX 5CUI 5CUJ 5CUM
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Activity Macromolecule Catabolic Process Protein Metabolic Process Notch Signaling Pathway Catabolic Process Proteolysis Protein Monoubiquitination Nucleotide Binding Protein Autoubiquitination Ubiquitin-like Protein Transferase Activity ATP Binding Intracellular Signal Transduction Ubiquitin-like Protein Ligase Binding Cellular Response To Tumor Cell Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Surface Receptor Signaling Pathway Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of BMP Signaling Pathway Defense Response Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Atrioventricular Node Development Protein-containing Complex Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleoplasm Regulation Of Cellular Response To Growth Factor Stimulus Immune Response Macromolecule Metabolic Process Positive Regulation Of Receptor Catabolic Process Signal Transduction TORC1 Signaling Negative Regulation Of BMP Signaling Pathway STAT Family Protein Binding Regulation Of Protein Ubiquitination Regulation Of Protein Modification Process Innate Immune Response Response To External Biotic Stimulus	Segment Specification Regulation Of Adaxial/abaxial Pattern Formation Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity RING-like Zinc Finger Domain Binding Rostrocaudal Neural Tube Patterning Entry Receptor-mediated Virion Attachment To Host Cell Viral Translation Viral Life Cycle Somite Specification Tryptophan Transport Positive Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Gap Junction Assembly Receptor-mediated Virion Attachment To Host Cell Somatic Stem Cell Division Ubiquitin-protein Transferase Activator Activity Regulation Of Immature T Cell Proliferation In Thymus Aromatic Amino Acid Transport Transporter Activator Activity Positive Regulation Of Cardiac Muscle Contraction Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Angiotensin Maturation Regulation Of Gap Junction Assembly Virion Attachment To Host Cell Drinking Behavior Positive Regulation Of Ubiquitin-protein Transferase Activity Adhesion Of Symbiont To Host Positive Regulation Of Striated Muscle Contraction Endocytosis Involved In Viral Entry Into Host Cell Regulation Of DNA-templated Transcription Regulation Of Leukocyte Cell-cell Adhesion Nuclear Body Regulation Of RNA Biosynthetic Process Somite Development Regulation Of T Cell Activation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?