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HMOX1 and ASL
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
HMOX1
ASL
Description
heme oxygenase 1
argininosuccinate lyase
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleoplasm
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Perinuclear Region Of Cytoplasm
Cytoplasm
Cytosol
Extracellular Exosome
Molecular Function
Heme Oxygenase (decyclizing) Activity
Structural Molecule Activity
Protein Binding
Oxidoreductase Activity
Enzyme Binding
Heme Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Catalytic Activity
Argininosuccinate Lyase Activity
Protein Binding
Lyase Activity
Identical Protein Binding
Biological Process
Angiogenesis
Endothelial Cell Proliferation
Wound Healing Involved In Inflammatory Response
Negative Regulation Of Leukocyte Migration
Regulation Of Transcription By RNA Polymerase II
Heme Oxidation
Intracellular Iron Ion Homeostasis
Apoptotic Process
Response To Oxidative Stress
Smooth Muscle Hyperplasia
Macroautophagy
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Positive Regulation Of Chemokine Production
Erythrocyte Homeostasis
Low-density Lipoprotein Particle Clearance
Cellular Response To Heat
Response To Nicotine
Intracellular Signal Transduction
Heme Catabolic Process
Heme Metabolic Process
Response To Hydrogen Peroxide
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Angiogenesis
Positive Regulation Of Angiogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Smooth Muscle Cell Proliferation
Multicellular Organismal-level Iron Ion Homeostasis
Cellular Response To Arsenic-containing Substance
Cellular Response To Cadmium Ion
Cellular Response To Cisplatin
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Ferroptosis
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Epithelial Cell Apoptotic Process
Positive Regulation Of Epithelial Cell Apoptotic Process
Urea Cycle
Amino Acid Metabolic Process
Arginine Metabolic Process
L-arginine Biosynthetic Process
Locomotory Behavior
Amino Acid Biosynthetic Process
Post-embryonic Development
Ammonia Assimilation Cycle
L-arginine Biosynthetic Process Via Ornithine
Positive Regulation Of Nitric Oxide Biosynthetic Process
L-amino Acid Metabolic Process
Pathways
Heme degradation
Interleukin-4 and Interleukin-13 signaling
The NLRP3 inflammasome
Iron uptake and transport
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Purinergic signaling in leishmaniasis infection
Cytoprotection by HMOX1
Cytoprotection by HMOX1
Regulation of HMOX1 expression and activity
Heme signaling
NFE2L2 regulating anti-oxidant/detoxification enzymes
Urea cycle
Drugs
NADH
Formic acid
Biliverdine IX Alpha
12-Phenylheme
2-Phenylheme
Verdoheme
Stannsoporfin
1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE
1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Arginine
Argininosuccinate
2-(N-morpholino)ethanesulfonic acid
Diseases
Argininosuccinic aciduria (ARGINSA); Argininosuccinate lyase deficiency
GWAS
Hippocampal volume in mild cognitive impairment (
29274321
)
Obesity-related traits (
23251661
)
Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease (
29748315
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
45 interacting genes:
AKT1
AQP6
ARL13B
ASL
BLVRB
CD79A
COQ9
CPLX4
CPSF1
CRB3
CREB3
CYB561
CYBRD1
ELOVL4
ELOVL5
ELOVL6
ERGIC3
FAM174A
FAM209A
FAM210B
FKBP7
GPR152
JAGN1
KASH5
LMNA
MSMO1
NOS1
PDZK1IP1
POR
POT1
PTGER4
SAR1A
SEC11C
SLC10A6
SLC16A7
SMO
STX1A
TERF1
TLCD4
TM4SF19
TMEM14B
TMIE
TMX2
TUT1
USP7
10 interacting genes:
CLK1
CSNK2A2
FBP1
HMOX1
MCMBP
NTAQ1
OVGP1
QARS1
SRPK2
TRIM3
Entrez ID
3162
435
HPRD ID
00782
01948
Ensembl ID
ENSG00000100292
ENSG00000126522
Uniprot IDs
P09601
Q6FH11
A0A024RDL8
A0A0S2Z316
P04424
PDB IDs
1N3U
1N45
1NI6
1OYK
1OYL
1OZE
1OZL
1OZR
1OZW
1S13
1S8C
1T5P
1TWN
1TWR
1XJZ
1XK0
1XK1
1XK2
1XK3
3CZY
3HOK
3K4F
3TGM
4WD4
5BTQ
6EHA
1AOS
1K62
Enriched GO Terms of Interacting Partners
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Membrane
Fatty Acid Elongation, Monounsaturated Fatty Acid
Fatty Acid Elongase Activity
Fatty Acid Elongation, Polyunsaturated Fatty Acid
Fatty Acid Elongation, Saturated Fatty Acid
Very Long-chain Fatty Acid Biosynthetic Process
Fatty Acid Elongation
Endoplasmic Reticulum
Peptidyl-cysteine S-nitrosylase Activity
Ascorbate Homeostasis
Long-chain Fatty-acyl-CoA Biosynthetic Process
Nitric Oxide Biosynthetic Process
Transmembrane Monodehydroascorbate Reductase Activity
Long-chain Fatty-acyl-CoA Metabolic Process
Fatty-acyl-CoA Biosynthetic Process
Nitric Oxide Metabolic Process
Reactive Nitrogen Species Metabolic Process
Regulation Of Establishment Of Protein Localization To Telomere
Shelterin Complex
Very Long-chain Fatty Acid Metabolic Process
Endoplasmic Reticulum Membrane
Regulation Of Establishment Of Protein Localization To Chromosome
Unsaturated Fatty Acid Biosynthetic Process
Meiotic Telomere Clustering
Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation
Small Molecule Biosynthetic Process
Regulation Of Telomere Maintenance
Nuclear Telomere Cap Complex
Telomere Localization
Telomeric D-loop Disassembly
Identical Protein Binding
G-rich Strand Telomeric DNA Binding
Telomeric Loop Disassembly
Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway
Fatty Acid Derivative Biosynthetic Process
Telomere Capping
Interleukin-18-mediated Signaling Pathway
Amide Biosynthetic Process
FMN Binding
Left/right Axis Specification
Protein Binding
Carboxylic Acid Metabolic Process
Negative Regulation Of TORC1 Signaling
Organic Acid Metabolic Process
MRNA Cleavage And Polyadenylation Specificity Factor Complex
Mammary Gland Epithelial Cell Differentiation
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Protein Serine Kinase Activity
Negative Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Catabolic Process
Phosphoric Ester Hydrolase Activity
Cellular Response To Raffinose
Fructose 1,6-bisphosphate 1-phosphatase Activity
Heme Oxidation
Smooth Muscle Hyperplasia
Heme Oxygenase (decyclizing) Activity
Wound Healing Involved In Inflammatory Response
Perivitelline Space
Glutamine-tRNA Ligase Activity
Glutaminyl-tRNA Aminoacylation
Protein-N-terminal Asparagine Amidohydrolase Activity
Protein-N-terminal Glutamine Amidohydrolase Activity
Regulation Of Apoptotic Signaling Pathway
Protein Serine/threonine Kinase Activity
Protein Kinase CK2 Complex
Cellular Hypotonic Salinity Response
Cytosol
Cellular Response To Cisplatin
Negative Regulation Of Binding Of Sperm To Zona Pellucida
Egg Coat
Nuclear Speck Organization
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Tagcloud (Intersection)
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