HMOX1 and GPR152

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HMOX1	GPR152
Description		heme oxygenase 1	G protein-coupled receptor 152
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane
	Molecular Function	Heme Oxygenase (decyclizing) Activity Structural Molecule Activity Protein Binding Oxidoreductase Activity Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	G Protein-coupled Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Angiogenesis Endothelial Cell Proliferation Wound Healing Involved In Inflammatory Response Negative Regulation Of Leukocyte Migration Regulation Of Transcription By RNA Polymerase II Heme Oxidation Intracellular Iron Ion Homeostasis Apoptotic Process Response To Oxidative Stress Smooth Muscle Hyperplasia Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Positive Regulation Of Chemokine Production Erythrocyte Homeostasis Low-density Lipoprotein Particle Clearance Cellular Response To Heat Response To Nicotine Intracellular Signal Transduction Heme Catabolic Process Heme Metabolic Process Response To Hydrogen Peroxide Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Cellular Response To Cisplatin Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Ferroptosis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways		Heme degradation Interleukin-4 and Interleukin-13 signaling The NLRP3 inflammasome Iron uptake and transport Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Cytoprotection by HMOX1 Cytoprotection by HMOX1 Regulation of HMOX1 expression and activity Heme signaling NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs		NADH Formic acid Biliverdine IX Alpha 12-Phenylheme 2-Phenylheme Verdoheme Stannsoporfin 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS		Hippocampal volume in mild cognitive impairment ( 29274321) Obesity-related traits ( 23251661) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278)
Interacting Genes		45 interacting genes: AKT1 AQP6 ARL13B ASL BLVRB CD79A COQ9 CPLX4 CPSF1 CRB3 CREB3 CYB561 CYBRD1 ELOVL4 ELOVL5 ELOVL6 ERGIC3 FAM174A FAM209A FAM210B FKBP7 GPR152 JAGN1 KASH5 LMNA MSMO1 NOS1 PDZK1IP1 POR POT1 PTGER4 SAR1A SEC11C SLC10A6 SLC16A7 SMO STX1A TERF1 TLCD4 TM4SF19 TMEM14B TMIE TMX2 TUT1 USP7	197 interacting genes: ABCG4 ABHD16A ACSF2 ADIPOQ AGTRAP AIG1 ANKRD46 APOL3 AQP10 AQP3 AQP6 ARL6IP1 ARV1 ATP6V0C B3GNT7 BDNF BET1 BMP10 BNIP2 BNIP3 C14orf180 C1QL4 C8A CCDC167 CCL4 CCL4L2 CD53 CD72 CD81 CDIPT CDS2 CGRRF1 CLDND2 CLEC17A CLEC1A CLN5 CNIH1 COL8A2 COMT CRISP3 CSGALNACT2 CTXN3 CYB561 CYB561A3 CYB5B CYB5R3 CYBC1 DEFB108B DGAT2L6 EBP EDDM3B EFNA5 EMD ERG28 ERGIC3 FA2H FAM209A FAM20B FAXDC2 FDFT1 FUNDC2 FXYD3 FXYD6-FXYD2 GAST GJB2 GOLT1A GOLT1B GOSR2 GPR151 GPR37L1 HHATL HMOX1 HMOX2 IFNA8 IGF2 IGFBP5 IL1RL1 INS-IGF2 INSIG2 JAGN1 KCNA1 KCNN4 LAMB1 LAT LEPROTL1 LHFPL2 LHFPL5 LTC4S MAL MAL2 MFF MFSD6 MGLL MGST3 MMD MOSPD3 MS4A13 MYADML2 NAT8 NDUFB11 NEU1 NINJ2 NIPAL4 ORMDL1 ORMDL3 PEDS1-UBE2V1 PEX16 PGAP2 PIGF PIN1 PLN PNLIPRP1 PRAF2 PROM2 PTPRN RABAC1 RBFA REEP6 ROBO2 RTN3 RTP2 SACM1L SCAMP4 SCD SEC22B SERF1A SERF1B SERP2 SFT2D2 SFTPC SLC10A1 SLC13A4 SLC29A2 SLC30A3 SLC35A4 SLC35B1 SLC35B4 SLC35F6 SLC35H1 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC61A1 SLC66A1 SLC66A2 SLC7A1 SMCO4 STATH STX1B STX3 STX4 STX5 STX8 SYT15 SYT15B TAP1 TEX264 TFRC THBD THSD7B TIMMDC1 TM4SF19 TMEM100 TMEM120B TMEM128 TMEM140 TMEM14B TMEM14C TMEM201 TMEM208 TMEM218 TMEM236 TMEM237 TMEM243 TMEM254 TMEM42 TMEM50B TMEM54 TMEM60 TMEM97 TMPPE TNFRSF10C TSNARE1 TSPAN33 TSPAN7 TSPO2 UBIAD1 UNC50 VAMP1 VAMP4 VAMP5 VKORC1 YIPF1 YIPF4 YIPF6 ZDHHC15
Entrez ID		3162	390212
HPRD ID		00782	13599
Ensembl ID		ENSG00000100292	ENSG00000175514
Uniprot IDs		P09601 Q6FH11	A0A0I9RJ67 Q8TDT2
PDB IDs		1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM 4WD4 5BTQ 6EHA
Enriched GO Terms of Interacting Partners?		Membrane Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Endoplasmic Reticulum Peptidyl-cysteine S-nitrosylase Activity Ascorbate Homeostasis Long-chain Fatty-acyl-CoA Biosynthetic Process Nitric Oxide Biosynthetic Process Transmembrane Monodehydroascorbate Reductase Activity Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Very Long-chain Fatty Acid Metabolic Process Endoplasmic Reticulum Membrane Regulation Of Establishment Of Protein Localization To Chromosome Unsaturated Fatty Acid Biosynthetic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Small Molecule Biosynthetic Process Regulation Of Telomere Maintenance Nuclear Telomere Cap Complex Telomere Localization Telomeric D-loop Disassembly Identical Protein Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway Fatty Acid Derivative Biosynthetic Process Telomere Capping Interleukin-18-mediated Signaling Pathway Amide Biosynthetic Process FMN Binding Left/right Axis Specification Protein Binding Carboxylic Acid Metabolic Process Negative Regulation Of TORC1 Signaling Organic Acid Metabolic Process MRNA Cleavage And Polyadenylation Specificity Factor Complex Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Release Of Cytochrome C From Mitochondria	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Endomembrane System Golgi Membrane Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Sterol Biosynthetic Process SNARE Binding Vesicle-mediated Transport Membrane Organization Membrane Fusion Lipid Biosynthetic Process Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Transmembrane Transport Cellular Localization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Organization Golgi Apparatus Cholesterol Biosynthetic Process Steroid Biosynthetic Process Membrane Docking Vesicle Docking Cortical Endoplasmic Reticulum Basolateral Plasma Membrane Lipid Metabolic Process Heme Oxidation Heme Oxygenase (decyclizing) Activity Lysine Transport Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Organelle Membrane Cholesterol Binding Nuclear Inner Membrane Organelle Localization By Membrane Tethering SNARE Complex Assembly Trans-Golgi Network Amyloid Fibril Formation Establishment Of Localization In Cell Establishment Of Protein Localization Nitric-oxide Synthase Complex UDP-glucose Transmembrane Transport Golgi Vesicle Transport Amino Acid Transmembrane Transport Water Channel Activity
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