HMOX1 and AQP6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HMOX1	AQP6
Description		heme oxygenase 1	aquaporin 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Perinuclear Region Of Cytoplasm	Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Heme Oxygenase (decyclizing) Activity Structural Molecule Activity Protein Binding Oxidoreductase Activity Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Monoatomic Anion Channel Activity Protein Binding Ammonium Channel Activity Nitrate Transmembrane Transporter Activity Water Channel Activity Channel Activity Carbon Dioxide Transmembrane Transporter Activity PH-gated Chloride Channel Activity
	Biological Process	Angiogenesis Endothelial Cell Proliferation Wound Healing Involved In Inflammatory Response Negative Regulation Of Leukocyte Migration Regulation Of Transcription By RNA Polymerase II Heme Oxidation Intracellular Iron Ion Homeostasis Apoptotic Process Response To Oxidative Stress Smooth Muscle Hyperplasia Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Positive Regulation Of Chemokine Production Erythrocyte Homeostasis Low-density Lipoprotein Particle Clearance Cellular Response To Heat Response To Nicotine Intracellular Signal Transduction Heme Catabolic Process Heme Metabolic Process Response To Hydrogen Peroxide Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Cellular Response To Cisplatin Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Ferroptosis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process	Renal Water Transport Carbon Dioxide Transport Nitrate Transmembrane Transport Carbon Dioxide Transmembrane Transport Odontogenesis Transmembrane Transport Ammonium Transmembrane Transport Monoatomic Anion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Heme degradation Interleukin-4 and Interleukin-13 signaling The NLRP3 inflammasome Iron uptake and transport Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Cytoprotection by HMOX1 Cytoprotection by HMOX1 Regulation of HMOX1 expression and activity Heme signaling NFE2L2 regulating anti-oxidant/detoxification enzymes	Passive transport by Aquaporins
Drugs		NADH Formic acid Biliverdine IX Alpha 12-Phenylheme 2-Phenylheme Verdoheme Stannsoporfin 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS		Hippocampal volume in mild cognitive impairment ( 29274321) Obesity-related traits ( 23251661) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		45 interacting genes: AKT1 AQP6 ARL13B ASL BLVRB CD79A COQ9 CPLX4 CPSF1 CRB3 CREB3 CYB561 CYBRD1 ELOVL4 ELOVL5 ELOVL6 ERGIC3 FAM174A FAM209A FAM210B FKBP7 GPR152 JAGN1 KASH5 LMNA MSMO1 NOS1 PDZK1IP1 POR POT1 PTGER4 SAR1A SEC11C SLC10A6 SLC16A7 SMO STX1A TERF1 TLCD4 TM4SF19 TMEM14B TMIE TMX2 TUT1 USP7	327 interacting genes: ABCG1 ABHD16A ACSL5 ADGRE2 ADIPOQ AGMO AGPAT3 AGPAT4 AGTRAP AIG1 ALOX5AP ANKRD46 AOC2 APOA2 APOL3 AQP1 ARL6IP1 ARL6IP6 ARLN ARV1 ATP13A1 ATP6V0C BET1 BMP10 BRICD5 BSG BTN2A2 C14orf180 C1GALT1 C2CD2L C3orf52 C5 C5orf46 CATSPERH CCDC167 CCL22 CCL4L2 CD52 CD68 CD81 CDIPT CGREF1 CLDN19 CLDN4 CLDND2 CMTM3 CMTM5 CMTM7 CNIH1 CNIH3 CORIN COX20 CTSA CTXN3 CXCL16 CXCL9 CXorf66 CYB561 CYB561A3 CYB561D1 CYB5B CYB5R3 CYBC1 CYP4F2 CYP4F22 DEFB103A DEFB103B DEFB108B DEFB127 DERL1 DGAT2L6 DHRSX DNAJC30 EBP EFNA5 EMC6 EMD EMP1 EMP3 ERG28 ERMP1 FA2H FAM177A1 FAXDC2 FDFT1 FIS1 FKBP8 FUNDC2 FXYD3 FXYD6 FXYD6-FXYD2 GAST GIMAP1 GIMAP5 GJB2 GKN1 GOLT1A GOSR2 GPR151 GPR152 GPR25 GRM2 GYPC HMOX1 HMOX2 HSD3B1 HTATIP2 ICMT IFITM3 IFNGR1 IGFBP5 INSIG1 INSIG2 ITGAM JAGN1 JPH1 KCNK1 LEMD1 LEPROT LHFPL5 LNPEP LPAR3 LSS LY6D MAL MAL2 MALL MARCHF2 MARCHF5 MFF MGAM MGLL MIP MMP14 MS4A1 MS4A13 MYADML2 NAT8 NEU1 NINJ1 NINJ2 NKG7 NRM ORMDL1 ORMDL2 ORMDL3 OTULINL PAEP PDZK1IP1 PEDS1-UBE2V1 PEMT PEX11G PEX16 PIGF PLLP PLN PLP1 PLP2 PLPP6 PMP22 PRAF2 PRB1 PRH1 PRRT2 PTPN1 PTPN9 RAB18 RABAC1 REEP6 RFT1 RHD RPRM RTP2 RUSF1 SACM1L SCAMP4 SCAMP5 SCD SCGB1A1 SEC22A SEC22B SEC61G SELENOK SERF1A SERF1B SERP1 SERP2 SFRP4 SFT2D1 SFT2D2 SFXN1 SFXN2 SFXN3 SFXN5 SLC16A12 SLC16A13 SLC25A46 SLC30A2 SLC30A3 SLC30A8 SLC33A2 SLC35A1 SLC35B1 SLC35B2 SLC35B4 SLC35E4 SLC35F1 SLC35F6 SLC35G2 SLC38A1 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC41A1 SLC41A2 SLC52A1 SLC61A1 SLC66A1 SLC66A2 SLC7A1 SLC7A8 SLCO3A1 SMAGP SMCO4 SMIM1 SNORC ST6GAL2 STARD3 STATH STRIT1 STX12 STX1B STX3 STX5 STX6 STX7 STX8 SYNDIG1 SYNGR1 SYNJ2BP TAP1 TBC1D20 TECR TFRC THBD THSD7A THSD7B TIMM23 TLCD1 TMEM100 TMEM107 TMEM11 TMEM115 TMEM119 TMEM120A TMEM120B TMEM128 TMEM140 TMEM143 TMEM144 TMEM14A TMEM14C TMEM167B TMEM19 TMEM203 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM242 TMEM243 TMEM254 TMEM42 TMEM50A TMEM51 TMEM60 TMEM65 TMEM69 TMEM74 TMEM86B TMEM97 TMIE TMUB2 TMX2 TNFRSF10C TOMM22 TOMM6 TPRG1 TREX1 TSNARE1 TSPO2 UBE2J1 UBE2J2 UBIAD1 UBTD2 UBXN8 UNC50 UNC93A UNC93B1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAPA VAPB VEZT VKORC1L1 VMA12 VMA21 VRK2 VSTM1 VTI1B WFS1 XKR3 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC21 ZDHHC24 ZFPL1 ZNF587
Entrez ID		3162	363
HPRD ID		00782	03226
Ensembl ID		ENSG00000100292	ENSG00000086159
Uniprot IDs		P09601 Q6FH11	Q13520
PDB IDs		1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM 4WD4 5BTQ 6EHA
Enriched GO Terms of Interacting Partners?		Membrane Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Endoplasmic Reticulum Peptidyl-cysteine S-nitrosylase Activity Ascorbate Homeostasis Long-chain Fatty-acyl-CoA Biosynthetic Process Nitric Oxide Biosynthetic Process Transmembrane Monodehydroascorbate Reductase Activity Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Very Long-chain Fatty Acid Metabolic Process Endoplasmic Reticulum Membrane Regulation Of Establishment Of Protein Localization To Chromosome Unsaturated Fatty Acid Biosynthetic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Small Molecule Biosynthetic Process Regulation Of Telomere Maintenance Nuclear Telomere Cap Complex Telomere Localization Telomeric D-loop Disassembly Identical Protein Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway Fatty Acid Derivative Biosynthetic Process Telomere Capping Interleukin-18-mediated Signaling Pathway Amide Biosynthetic Process FMN Binding Left/right Axis Specification Protein Binding Carboxylic Acid Metabolic Process Negative Regulation Of TORC1 Signaling Organic Acid Metabolic Process MRNA Cleavage And Polyadenylation Specificity Factor Complex Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Release Of Cytochrome C From Mitochondria	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Endomembrane System Membrane Organization Membrane Fusion Vesicle Fusion Organelle Membrane Fusion Cellular Localization Establishment Of Protein Localization Organelle Fusion Golgi Membrane Lipid Biosynthetic Process Transmembrane Transport Sterol Biosynthetic Process Membrane Docking Organelle Localization By Membrane Tethering SNARE Binding Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle-mediated Transport Steroid Biosynthetic Process Intracellular Transport Plasma Membrane Vesicle Organization Vesicle Docking Synaptic Vesicle Membrane Cholesterol Biosynthetic Process Golgi Vesicle Transport Amino Acid Transport Structural Constituent Of Myelin Sheath Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Sterol Metabolic Process Chemical Homeostasis Monoatomic Ion Transmembrane Transporter Activity Establishment Of Localization In Cell Mitochondrial Outer Membrane Organic Anion Transport Zinc Ion Transmembrane Transporter Activity Mitochondrial Transport Amino Acid Transmembrane Transport Serine Import Into Mitochondrion Cytoplasmic Vesicle Zinc Ion Transmembrane Transport Transmembrane Transporter Activity Zinc Ion Transport Establishment Of Protein Localization To Membrane
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