HMOX1 and CYBRD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HMOX1	CYBRD1
Description		heme oxygenase 1	cytochrome b reductase 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Perinuclear Region Of Cytoplasm	Lysosomal Membrane Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Heme Oxygenase (decyclizing) Activity Structural Molecule Activity Protein Binding Oxidoreductase Activity Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions Identical Protein Binding Metal Ion Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity
	Biological Process	Angiogenesis Endothelial Cell Proliferation Wound Healing Involved In Inflammatory Response Negative Regulation Of Leukocyte Migration Regulation Of Transcription By RNA Polymerase II Heme Oxidation Intracellular Iron Ion Homeostasis Apoptotic Process Response To Oxidative Stress Smooth Muscle Hyperplasia Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Positive Regulation Of Chemokine Production Erythrocyte Homeostasis Low-density Lipoprotein Particle Clearance Cellular Response To Heat Response To Nicotine Intracellular Signal Transduction Heme Catabolic Process Heme Metabolic Process Response To Hydrogen Peroxide Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Cellular Response To Cisplatin Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Ferroptosis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process	Intracellular Iron Ion Homeostasis Response To Iron Ion Reductive Iron Assimilation Transmembrane Transport Multicellular Organismal-level Iron Ion Homeostasis Ascorbate Homeostasis
Pathways		Heme degradation Interleukin-4 and Interleukin-13 signaling The NLRP3 inflammasome Iron uptake and transport Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Cytoprotection by HMOX1 Cytoprotection by HMOX1 Regulation of HMOX1 expression and activity Heme signaling NFE2L2 regulating anti-oxidant/detoxification enzymes	Iron uptake and transport
Drugs		NADH Formic acid Biliverdine IX Alpha 12-Phenylheme 2-Phenylheme Verdoheme Stannsoporfin 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS		Hippocampal volume in mild cognitive impairment ( 29274321) Obesity-related traits ( 23251661) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823) Asthma (childhood onset) ( 34022066) Body fat distribution (arm fat ratio) ( 30664634) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Pulse pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		45 interacting genes: AKT1 AQP6 ARL13B ASL BLVRB CD79A COQ9 CPLX4 CPSF1 CRB3 CREB3 CYB561 CYBRD1 ELOVL4 ELOVL5 ELOVL6 ERGIC3 FAM174A FAM209A FAM210B FKBP7 GPR152 JAGN1 KASH5 LMNA MSMO1 NOS1 PDZK1IP1 POR POT1 PTGER4 SAR1A SEC11C SLC10A6 SLC16A7 SMO STX1A TERF1 TLCD4 TM4SF19 TMEM14B TMIE TMX2 TUT1 USP7	20 interacting genes: CREB3 FKBP8 GIMAP5 GOSR2 HMOX1 LMNA LPAR3 NEDD4L PLP2 RABAC1 SEC22A SERP1 SERP2 STX4 STX7 TMEM120A TMEM65 VAPA VAPB ZFPL1
Entrez ID		3162	79901
HPRD ID		00782	05764
Ensembl ID		ENSG00000100292	ENSG00000071967
Uniprot IDs		P09601 Q6FH11	Q53TN4
PDB IDs		1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM 4WD4 5BTQ 6EHA	5ZLE 5ZLG
Enriched GO Terms of Interacting Partners?		Membrane Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Endoplasmic Reticulum Peptidyl-cysteine S-nitrosylase Activity Ascorbate Homeostasis Long-chain Fatty-acyl-CoA Biosynthetic Process Nitric Oxide Biosynthetic Process Transmembrane Monodehydroascorbate Reductase Activity Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Very Long-chain Fatty Acid Metabolic Process Endoplasmic Reticulum Membrane Regulation Of Establishment Of Protein Localization To Chromosome Unsaturated Fatty Acid Biosynthetic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Small Molecule Biosynthetic Process Regulation Of Telomere Maintenance Nuclear Telomere Cap Complex Telomere Localization Telomeric D-loop Disassembly Identical Protein Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway Fatty Acid Derivative Biosynthetic Process Telomere Capping Interleukin-18-mediated Signaling Pathway Amide Biosynthetic Process FMN Binding Left/right Axis Specification Protein Binding Carboxylic Acid Metabolic Process Negative Regulation Of TORC1 Signaling Organic Acid Metabolic Process MRNA Cleavage And Polyadenylation Specificity Factor Complex Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Release Of Cytochrome C From Mitochondria	Endoplasmic Reticulum Membrane SNAP Receptor Activity Endoplasmic Reticulum Membrane Organization Membrane Fusion Endoplasmic Reticulum Unfolded Protein Response Organelle Localization By Membrane Tethering Membrane Docking Response To Unfolded Protein FFAT Motif Binding Membrane COPII-coated Vesicle Budding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum-plasma Membrane Tethering SNARE Complex Vesicle Organization Vesicle-mediated Transport Endoplasmic Reticulum Localization SNARE Binding Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral Genome Replication Host-mediated Suppression Of Viral Genome Replication Response To Endoplasmic Reticulum Stress Organelle Localization Vesicle Fusion Organelle Membrane Fusion Endomembrane System Intracellular Transport Golgi Vesicle Transport Organelle Fusion Viral Release From Host Cell Intracellular Protein Localization Endoplasmic Reticulum Exit Site Viral Process Vesicle Budding From Membrane Protein-membrane Adaptor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Host-mediated Activation Of Viral Process Positive Regulation Of Developmental Growth Regulation Of Protein Localization To Cell Surface Regulation Of Apoptotic Signaling Pathway Perinuclear Region Of Cytoplasm Cellular Localization Protein Transport Sphingomyelin Phosphodiesterase Activator Activity Positive Regulation Of Deacetylase Activity Establishment Of Localization In Cell Cellular Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Heme Oxidation
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