HMOX1 and TMEM14B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HMOX1	TMEM14B
Description		heme oxygenase 1	transmembrane protein 14B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Perinuclear Region Of Cytoplasm	Membrane Mitochondrial Membrane
	Molecular Function	Heme Oxygenase (decyclizing) Activity Structural Molecule Activity Protein Binding Oxidoreductase Activity Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Angiogenesis Endothelial Cell Proliferation Wound Healing Involved In Inflammatory Response Negative Regulation Of Leukocyte Migration Regulation Of Transcription By RNA Polymerase II Heme Oxidation Intracellular Iron Ion Homeostasis Apoptotic Process Response To Oxidative Stress Smooth Muscle Hyperplasia Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Positive Regulation Of Chemokine Production Erythrocyte Homeostasis Low-density Lipoprotein Particle Clearance Cellular Response To Heat Response To Nicotine Intracellular Signal Transduction Heme Catabolic Process Heme Metabolic Process Response To Hydrogen Peroxide Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Cellular Response To Cisplatin Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Ferroptosis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process	Heme Biosynthetic Process Nervous System Development Cerebral Cortex Development Neural Precursor Cell Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Heme degradation Interleukin-4 and Interleukin-13 signaling The NLRP3 inflammasome Iron uptake and transport Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Cytoprotection by HMOX1 Cytoprotection by HMOX1 Regulation of HMOX1 expression and activity Heme signaling NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs		NADH Formic acid Biliverdine IX Alpha 12-Phenylheme 2-Phenylheme Verdoheme Stannsoporfin 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS		Hippocampal volume in mild cognitive impairment ( 29274321) Obesity-related traits ( 23251661) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)
Interacting Genes		45 interacting genes: AKT1 AQP6 ARL13B ASL BLVRB CD79A COQ9 CPLX4 CPSF1 CRB3 CREB3 CYB561 CYBRD1 ELOVL4 ELOVL5 ELOVL6 ERGIC3 FAM174A FAM209A FAM210B FKBP7 GPR152 JAGN1 KASH5 LMNA MSMO1 NOS1 PDZK1IP1 POR POT1 PTGER4 SAR1A SEC11C SLC10A6 SLC16A7 SMO STX1A TERF1 TLCD4 TM4SF19 TMEM14B TMIE TMX2 TUT1 USP7	235 interacting genes: ABHD16A ABHD5 ACSL5 ADAM33 AGPAT3 AGPAT4 AGR3 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARL8B ARV1 ATP13A1 B4GALT7 BIK BLCAP BMP10 BSG BTN2A2 C10orf67 C14orf180 C1GALT1 C2CD2L CCL4 CD79A CEPT1 CFHR5 CIDEB CLDN10 CLDND2 CMTM5 CMTM8 CNIH2 CNIH3 CNIH4 COMT CPLX4 CREB3 CREB3L1 CXCL16 CYB561 CYB5R3 DEFB103A DEFB103B DGAT2L6 DHRSX EBP EI24 EMC6 EPHX4 ERGIC3 EXTL1 FA2H FADS6 FAM209A FCER1G FHL3 FIS1 FKBP8 FUNDC2 FXYD6-FXYD2 GDAP1 GIMAP1 GPR152 GPX8 GYPA GYPC HEXB HIBADH HIGD1C HMOX1 HMOX2 HSD17B11 HSD17B13 HSD3B1 IER3IP1 IFITM3 INSIG2 ITGAM JAGN1 KCNA1 KCNK1 KHDRBS2 LEPROTL1 LMNA LPAR3 LRCH1 MAL2 MARCHF5 MEOX2 MFSD12 MGAM MID2 MMD2 MS4A13 MS4A4A NAT8 NCALD NDUFA3 NEU1 NINJ1 NINJ2 NIPAL3 ORMDL1 OTULINL PAGE1 PDPN PDZK1IP1 PEX11G PIGF PLLP PLP1 PLP2 PMP22 PNLIPRP1 PPP2R3B PRAF2 PRH1 PRTFDC1 PSMD3 PTPMT1 RABAC1 REEP4 RHD RHOT2 SAR1B SCAMP5 SCN3B SCRG1 SERF1A SERF1B SERP1 SERP2 SFT2D1 SFT2D2 SFXN1 SFXN2 SFXN3 SLC10A6 SLC16A10 SLC16A13 SLC18A1 SLC19A3 SLC2A6 SLC30A3 SLC30A8 SLC35A4 SLC35E3 SLC35E4 SLC35F1 SLC35F6 SLC35G1 SLC35H1 SLC39A2 SLC39A7 SLC48A1 SLC61A1 SLC7A8 SMAGP SMPD2 SPRY2 SQLE ST6GAL2 STOM STX12 STX3 STX6 STX8 SUCNR1 SYNGR1 SYNJ2BP TAP1 TAS2R19 TBC1D20 TEX44 THBD TIMM22 TIMM23 TIMMDC1 TLCD1 TM4SF4 TMEM11 TMEM120A TMEM120B TMEM121 TMEM147 TMEM14A TMEM14C TMEM187 TMEM19 TMEM203 TMEM220 TMEM222 TMEM229B TMEM243 TMEM254 TMEM255B TMEM267 TMEM42 TMEM50A TMEM50B TMEM51 TMEM60 TMEM69 TMEM97 TMIE TMUB1 TMX2 TOMM6 TSPAN2 TSPO TVP23B UBE2J1 UBE2J2 UBE3A UBIAD1 UBXN8 UNC50 UNC93A VAMP1 VAMP5 VMA12 VRK2 VTI1B YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC11 ZDHHC22 ZDHHC24 ZFPL1
Entrez ID		3162	81853
HPRD ID		00782	15523
Ensembl ID		ENSG00000100292	ENSG00000137210
Uniprot IDs		P09601 Q6FH11	A0A087WU83 C9JCY4 C9JQS0 Q9NUH8
PDB IDs		1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM 4WD4 5BTQ 6EHA
Enriched GO Terms of Interacting Partners?		Membrane Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Endoplasmic Reticulum Peptidyl-cysteine S-nitrosylase Activity Ascorbate Homeostasis Long-chain Fatty-acyl-CoA Biosynthetic Process Nitric Oxide Biosynthetic Process Transmembrane Monodehydroascorbate Reductase Activity Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Very Long-chain Fatty Acid Metabolic Process Endoplasmic Reticulum Membrane Regulation Of Establishment Of Protein Localization To Chromosome Unsaturated Fatty Acid Biosynthetic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Small Molecule Biosynthetic Process Regulation Of Telomere Maintenance Nuclear Telomere Cap Complex Telomere Localization Telomeric D-loop Disassembly Identical Protein Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway Fatty Acid Derivative Biosynthetic Process Telomere Capping Interleukin-18-mediated Signaling Pathway Amide Biosynthetic Process FMN Binding Left/right Axis Specification Protein Binding Carboxylic Acid Metabolic Process Negative Regulation Of TORC1 Signaling Organic Acid Metabolic Process MRNA Cleavage And Polyadenylation Specificity Factor Complex Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Release Of Cytochrome C From Mitochondria	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Endomembrane System Golgi Apparatus Lipid Biosynthetic Process Membrane Organization Cellular Localization Transmembrane Transport Golgi Membrane Mitochondrial Outer Membrane Transmembrane Transporter Activity Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Establishment Of Protein Localization Serine Import Into Mitochondrion Organic Cation Transport SNARE Complex Structural Constituent Of Myelin Sheath Mitochondrial Membrane SNAP Receptor Activity Organelle Fusion Monoatomic Ion Transmembrane Transporter Activity Steroid Biosynthetic Process Amino Acid Transport Myelination Axon Ensheathment Vesicle Fusion Organic Hydroxy Compound Transport Organelle Membrane Fusion Lipid Homeostasis Heme Metabolic Process Pigment Metabolic Process Cholesterol Biosynthetic Process Golgi Trans Cisterna Import Into The Mitochondrion COPII-coated ER To Golgi Transport Vesicle Lipid Metabolic Process Heme Oxidation Heme Oxygenase (decyclizing) Activity Amino Acid Transmembrane Transport Golgi Medial Cisterna SNARE Binding Zinc Ion Transmembrane Transporter Activity Sterol Biosynthetic Process Serine Transport Porphyrin-containing Compound Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Chemical Homeostasis
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