RRAD and CAMK2G

Number of citations of the paper that reports this interaction (PubMedID 9677319)
21

Data Source:
BioGRID (pull down, enzymatic study, enzymatic study)
HPRD (in vitro)

		RRAD	CAMK2G
Description		RRAD, Ras related glycolysis inhibitor and calcium channel regulator	calcium/calmodulin dependent protein kinase II gamma
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection
	Molecular Function	Nucleotide Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Small GTPase-mediated Signal Transduction	Nervous System Development Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Cell Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Regulation Of Protein Localization To Plasma Membrane
Pathways		NGF-stimulated transcription	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Fostamatinib
Diseases
GWAS		Waist circumference adjusted for body mass index ( 34021172)	Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) FEV1 ( 30804560) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458)
Interacting Genes		15 interacting genes: CALM1 CAMK2G CCDC141 CSNK2A1 CSNK2B EEA1 EGFR MMP14 NME1 PRKACA PRKCA PRKCB STAT3 TPM2 YWHAZ	51 interacting genes: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CDC37 CEBPA CHAT CREM DUS1L EGFR ESRRG FLNA FXR1 FXR2 GRIA1 GRIA4 GRIN1 GRIN2B KANK2 KRTAP19-3 KRTAP6-1 KRTAP6-3 LRRC7 MAP3K7 MRPL11 MYLK NUTF2 NXF1 PEA15 PLCB3 PSMB1 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 STRBP SYN1 TH TIAM1 TNPO2 TNPO3 TTC5 UBE2I
Entrez ID		6236	818
HPRD ID		01536	03672
Ensembl ID		ENSG00000166592	ENSG00000148660
Uniprot IDs		P55042	A0A2Q3DQE3 B3KY86 H0Y6G2 Q13280 Q13555 Q5SWX3
PDB IDs		2DPX 2GJS 3Q72 3Q7P 3Q7Q	2UX0 2V7O
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Serine/threonine Kinase Activity Phosphorylation Histone H3T6 Kinase Activity Cytosol Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Kinase C Signaling Regulation Of Protein Localization Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Protein Phosphorylation Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Cytoplasm Regulation Of Signal Transduction Mitotic Nuclear Membrane Disassembly Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Establishment Of Protein Localization Identical Protein Binding Interleukin-2-mediated Signaling Pathway Intracellular Signaling Cassette Regulation Of Muscle System Process Positive Regulation Of Insulin Secretion Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphatase Binding Nuclear Membrane Disassembly ATP Binding Regulation Of Biological Quality Membrane Disassembly Negative Regulation Of Signal Transduction Diacylglycerol-dependent Serine/threonine Kinase Activity Signal Transduction Calyx Of Held Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Estradiol Negative Regulation Of Glycolytic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion	Intracellular Signaling Cassette Intracellular Signal Transduction Cytoplasm Synapse Cytosol Neuron Projection SMAD Protein Complex Identical Protein Binding Learning Or Memory Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Heteromeric SMAD Protein Complex Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Cognition Chemical Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Signal Transduction Trans-synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Synaptic Signaling Positive Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Kinase Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Modulation Of Excitatory Postsynaptic Potential I-SMAD Binding Postsynaptic Density Membrane Glutamate Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Monoatomic Ion Transmembrane Transport Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Calmodulin Binding Regulation Of Neuronal Synaptic Plasticity Nuclear Import Signal Receptor Activity Regulation Of Monoatomic Ion Transport Regulation Of Synaptic Plasticity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Cell Development Positive Regulation Of Signaling Ameboidal-type Cell Migration
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?