RRAD and MMP14

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RRAD	MMP14
Gene Name		Ras-related associated with diabetes	matrix metallopeptidase 14 (membrane-inserted)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane	Cytoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Melanosome
	Molecular Function	GTPase Activity Protein Binding Calmodulin Binding GTP Binding	Sequence-specific DNA Binding Transcription Factor Activity Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Peptidase Activator Activity
	Biological Process	Small GTPase Mediated Signal Transduction	Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Regulation Of Transcription, DNA-templated Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Peptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Negative Regulation Of Focal Adhesion Assembly Craniofacial Suture Morphogenesis
Pathways			Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CALM1 CAMK2G CSNK2A1 CSNK2B MMP14 NME1 PRKACA PRKCA PRKCB TPM2 YWHAZ	23 interactors: ACAN ADI1 BCAR1 C1QBP CAV1 CCDC155 CCL7 CLDN1 F12 ITGAV KISS1 LRP1 LUM MMP13 MMP2 PLLP RRAD SDC1 SPOCK1 SPOCK3 TIMP2 TIMP3 TIMP4
Entrez ID		6236	4323
HPRD ID		01536	02856
Ensembl ID		ENSG00000166592	ENSG00000157227
Uniprot IDs		P55042	P50281
PDB IDs		2DPX 2GJS 3Q72 3Q7P 3Q7Q	1BQQ 1BUV 3C7X 3MA2
Enriched GO Terms of Interacting Partners?		Histone H3-T6 Phosphorylation Phosphorylation Platelet Activation Negative Regulation Of Glucose Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Rhodopsin Mediated Signaling Pathway Activation Of Adenylate Cyclase Activity Phosphate-containing Compound Metabolic Process Rhodopsin Mediated Signaling Pathway Mitotic Cell Cycle Positive Regulation Of Adenylate Cyclase Activity Mitotic Nuclear Envelope Disassembly Negative Regulation Of Insulin Receptor Signaling Pathway Blood Coagulation Hemostasis Nuclear Envelope Disassembly Histone Phosphorylation Regulation Of Blood Vessel Endothelial Cell Migration Peptidyl-threonine Phosphorylation Positive Regulation Of Lyase Activity Cell-cell Signaling Activation Of Phospholipase C Activity Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of Body Fluid Levels Nuclear Envelope Organization Positive Regulation Of CAMP Metabolic Process Synaptic Transmission Wound Healing Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Phospholipase Activity Cellular Response To Carbohydrate Stimulus Phototransduction, Visible Light Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Activation Regulation Of Phospholipase Activity Mitotic Cell Cycle Process Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lipase Activity Positive Regulation Of Signal Transduction Detection Of Visible Light Response To Wounding Desmosome Assembly	Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Protein Processing Regulation Of Peptidase Activity Extracellular Matrix Disassembly Response To Wounding Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Sulfur Compound Metabolic Process Wound Healing Negative Regulation Of Proteolysis Response To Stimulus Glycosaminoglycan Catabolic Process Glycosaminoglycan Metabolic Process Negative Regulation Of Protein Processing System Development Anatomical Structure Development Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Hydrolase Activity Regulation Of Cellular Component Movement Blood Coagulation Hemostasis Keratan Sulfate Catabolic Process Response To Organic Substance Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Developmental Process Regulation Of Protein Metabolic Process Multicellular Organismal Development Blood Coagulation, Intrinsic Pathway Glycosaminoglycan Biosynthetic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Proteoglycan Metabolic Process Response To External Stimulus Negative Regulation Of Protein Catabolic Process Regulation Of Cell Migration Response To Hormone Positive Regulation Of Cell Migration Keratan Sulfate Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Cell Motility Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Keratan Sulfate Metabolic Process
Tagcloud ?		abolishes antagonizing biosynthetic blocking contributes demands display drives ectopic energetic glut1 glycolysis greatly hypoxia hypoxic meet microenvironmental newly normoxia p53 promotes reduces represses repressing stimulating suppression switch translocation turn	5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide
Tagcloud (Difference) ?		abolishes antagonizing biosynthetic blocking contributes demands display drives ectopic energetic glut1 glycolysis greatly hypoxia hypoxic meet microenvironmental newly normoxia p53 reduces represses repressing stimulating suppression switch translocation turn	5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress qpcr re reverses suppresses tissues validated worldwide
Tagcloud (Intersection) ?		promotes