NKG7 and MS4A3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NKG7	MS4A3
Name		natural killer cell granule protein 7	membrane spanning 4-domains A3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Plasma Membrane Membrane Cytolytic Granule Cytolytic Granule Membrane	Cytoplasm Plasma Membrane Endomembrane System Membrane Specific Granule Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Inflammatory Response Killing Of Cells Of Another Organism CD4-positive, Alpha-beta T Cell Activation Natural Killer Cell Mediated Cytotoxicity Defense Response To Protozoan Natural Killer Cell Degranulation Positive Regulation Of Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway	None
Pathways		None	Neutrophil degranulation
GWAS		Neutrophil count ( 27863252 32888494 ) Neutrophil percentage of white cells ( 32888494 )	Alzheimer's disease ( 24755620 ) Vitamin B12 levels ( 22367966 )
Novel Interactors		2 novel interactors: PLEKHF2 PRRG2	1 novel interactors: CDK2
Interacting Genes		49 interacting genes: AGTRAP AMIGO1 AQP6 ARL13B ATP6AP2 BAMBI CD53 CD79A CLDN7 CLEC2D CLEC4E CLSTN3 CREB3 EBP EDA2R ERGIC3 FAM209A FAM210B FFAR2 FKBP7 FNDC9 GJA5 GORAB GPX8 ISLR2 KLRC1 LHFPL5 LMNA MFSD6 MGST3 MS4A3 MSR1 MUC1 OPRK1 PEX12 RAMP1 RNF24 SLC10A1 SLC18A2 SLC30A8 SLC35H1 STOM STX1A TLCD4 TMEM106C TMEM130 TMEM139 TMEM80 TMEM88	38 interacting genes: ADIPOQ ARLN ATP6V0B BMP10 BNIP3 CCDC167 CD53 CD72 CDKN3 CLDN1 CLDN6 EFNA5 EMP3 ERG28 IFITM3 IGFBP5 MS4A13 NKG7 PLP1 PLPP6 SEC22A SGTA SLC22A14 SLC5A4 SMCO4 SMIM3 STX8 TEX264 TM4SF18 TMBIM6 TMEM107 TMEM140 TMEM182 TMEM218 TMEM239 VKORC1L1 YIPF6 ZFPL1
Entrez ID		4818	932
HPRD ID		16188	09403
Ensembl ID		ENSG00000105374	ENSG00000149516
Uniprot IDs		A0A0B4J2A6 Q16617	Q96HJ5
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane Plasma Membrane Protein Binding	Membrane