MS4A3 and CDKN3

Number of citations of the paper that reports this interaction (PubMedID 11781350)
43

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		MS4A3	CDKN3
Description		membrane spanning 4-domains A3	cyclin dependent kinase inhibitor 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Endomembrane System Membrane Specific Granule Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity
	Biological Process		Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Regulation Of Cell Cycle
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Alzheimer's disease ( 24755620) Vitamin B12 levels ( 22367966)	Cortical volume ( 32963231) Dental caries ( 23259602) Endometrial cancer (Non-endometrioid histology) ( 30093612) High myopia ( 31816047) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Monobrow thickness ( 26926045) Myopia ( 27182965) Refractive error ( 32231278) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		38 interacting genes: ADIPOQ ARLN ATP6V0B BMP10 BNIP3 CCDC167 CD53 CD72 CDKN3 CLDN1 CLDN6 EFNA5 EMP3 ERG28 IFITM3 IGFBP5 MS4A13 NKG7 PLP1 PLPP6 SEC22A SGTA SLC22A14 SLC5A4 SMCO4 SMIM3 STX8 TEX264 TM4SF18 TMBIM6 TMEM107 TMEM140 TMEM182 TMEM218 TMEM239 VKORC1L1 YIPF6 ZFPL1	9 interacting genes: CDC25A CDK1 CDK2 CDK3 CEBPA MS4A3 NCOA3 PPP1R12A ROCK2
Entrez ID		932	1033
HPRD ID		09403	00450
Ensembl ID		ENSG00000149516	ENSG00000100526
Uniprot IDs		Q96HJ5	G3V2J7 Q16667
PDB IDs			1FPZ 1FQ1
Enriched GO Terms of Interacting Partners?		Membrane	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Cyclin Binding Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Positive Regulation Of DNA Replication Cyclin-dependent Protein Kinase Holoenzyme Complex G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Histone Kinase Activity Regulation Of Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule Organizing Center Organization Mitotic Nuclear Membrane Disassembly Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of DNA Replication Nuclear Membrane Disassembly Membrane Disassembly Protein Serine/threonine Kinase Activity Regulation Of Establishment Of Endothelial Barrier Centrosome Duplication Regulation Of Cell Cycle Phase Transition Cell Division Nuclear Envelope Organization Regulation Of Epithelial Cell Differentiation Regulation Of Mitotic Cell Cycle Protein Kinase Activity Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of Keratinocyte Differentiation Kinase Activity Regulation Of Endothelial Cell Differentiation Centrosome Positive Regulation Of Cell Cycle Process Centrosome Cycle Nuclear Membrane Organization Positive Regulation Of Metabolic Process Cell Population Proliferation Positive Regulation Of DNA Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Epidermal Cell Differentiation Pronuclear Fusion Cellular Response To Xenobiotic Stimulus
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