NKG7 and TMEM130

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NKG7	TMEM130
Description		natural killer cell granule protein 7	transmembrane protein 130
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Plasma Membrane Membrane Cytolytic Granule Cytolytic Granule Membrane	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Inflammatory Response Killing Of Cells Of Another Organism CD4-positive, Alpha-beta T Cell Activation Natural Killer Cell Mediated Cytotoxicity Defense Response To Protozoan Natural Killer Cell Degranulation Positive Regulation Of Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494)	Decreased low contrast letter acuity in multiple sclerosis ( 31289819)
Interacting Genes		49 interacting genes: AGTRAP AMIGO1 AQP6 ARL13B ATP6AP2 BAMBI CD53 CD79A CLDN7 CLEC2D CLEC4E CLSTN3 CREB3 EBP EDA2R ERGIC3 FAM209A FAM210B FFAR2 FKBP7 FNDC9 GJA5 GORAB GPX8 ISLR2 KLRC1 LHFPL5 LMNA MFSD6 MGST3 MS4A3 MSR1 MUC1 OPRK1 PEX12 RAMP1 RNF24 SLC10A1 SLC18A2 SLC30A8 SLC35H1 STOM STX1A TLCD4 TMEM106C TMEM130 TMEM139 TMEM80 TMEM88	10 interacting genes: GRM2 NKG7 OLFM4 PIGF SLC2A5 SLC35B4 SLC61A1 TMEM100 TSPAN2 YIPF6
Entrez ID		4818	222865
HPRD ID		16188	13226
Ensembl ID		ENSG00000105374	ENSG00000166448
Uniprot IDs		A0A0B4J2A6 Q16617	Q8N3G9
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding	Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Fructose Import Across Plasma Membrane UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Organic Anion Transport Group II Metabotropic Glutamate Receptor Activity Membrane Ethanolaminephosphotransferase Activity Microglia Development UDP-N-acetylglucosamine Transmembrane Transporter Activity UDP-N-acetylglucosamine Transmembrane Transport
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