NKG7 and CLEC4E

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NKG7	CLEC4E
Description		natural killer cell granule protein 7	C-type lectin domain family 4 member E
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Plasma Membrane Membrane Cytolytic Granule Cytolytic Granule Membrane	Phagocytic Cup Plasma Membrane External Side Of Plasma Membrane Membrane Phagocytic Vesicle Membrane Cell Projection
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding Carbohydrate Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Metal Ion Binding Glycolipid Binding
	Biological Process	Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Inflammatory Response Killing Of Cells Of Another Organism CD4-positive, Alpha-beta T Cell Activation Natural Killer Cell Mediated Cytotoxicity Defense Response To Protozoan Natural Killer Cell Degranulation Positive Regulation Of Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway	Positive Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway T Cell Differentiation Involved In Immune Response Immune System Process Immune Response-regulating Signaling Pathway Immune Response Fc-gamma Receptor Signaling Pathway Defense Response To Bacterium Innate Immune Response Antifungal Innate Immune Response
Pathways			Dectin-2 family Dectin-2 family
Drugs			Cholesterol
Diseases
GWAS		Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494)	Takayasu arteritis ( 25604533)
Interacting Genes		49 interacting genes: AGTRAP AMIGO1 AQP6 ARL13B ATP6AP2 BAMBI CD53 CD79A CLDN7 CLEC2D CLEC4E CLSTN3 CREB3 EBP EDA2R ERGIC3 FAM209A FAM210B FFAR2 FKBP7 FNDC9 GJA5 GORAB GPX8 ISLR2 KLRC1 LHFPL5 LMNA MFSD6 MGST3 MS4A3 MSR1 MUC1 OPRK1 PEX12 RAMP1 RNF24 SLC10A1 SLC18A2 SLC30A8 SLC35H1 STOM STX1A TLCD4 TMEM106C TMEM130 TMEM139 TMEM80 TMEM88	4 interacting genes: CXCL9 FAM3C FCER1G NKG7
Entrez ID		4818	26253
HPRD ID		16188	13075
Ensembl ID		ENSG00000105374	ENSG00000166523
Uniprot IDs		A0A0B4J2A6 Q16617	F5H5X7 Q9ULY5
PDB IDs			3WH2 3WH3
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding	Granulocyte Migration Defense Response Neutrophil Chemotaxis Myeloid Leukocyte Migration IgE Receptor Activity Regulated Exocytosis Defense Response To Other Organism Leukocyte Degranulation Granulocyte Chemotaxis Neutrophil Migration Lymphocyte Mediated Immunity Defense Response To Symbiont Inflammatory Response Killing Of Cells Of Another Organism Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Leukocyte Chemotaxis Positive Regulation Of Type I Hypersensitivity Leukocyte Mediated Immunity Myeloid Leukocyte Differentiation Fc-epsilon Receptor I Complex Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet Fc-gamma Receptor III Complex Positive Regulation Of Inflammatory Response Positive Regulation Of Type III Hypersensitivity Cell Killing Cell Chemotaxis Mast Cell Apoptotic Process Serotonin Secretion Positive Regulation Of Type IIa Hypersensitivity Exocytosis Cytokine Activity Cytolytic Granule Membrane Response To Other Organism Leukocyte Migration Response To Stress Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process CXCR3 Chemokine Receptor Binding Immune Response Myeloid Cell Differentiation Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Natural Killer Cell Degranulation Immune Response To Tumor Cell Response To External Biotic Stimulus Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation T Cell Activation
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