MS4A3 and CD72

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MS4A3	CD72
Description		membrane spanning 4-domains A3	CD72 molecule
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Endomembrane System Membrane Specific Granule Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Carbohydrate Binding
	Biological Process		Cell Adhesion Negative Regulation Of B Cell Receptor Signaling Pathway
Pathways		Neutrophil degranulation	Other semaphorin interactions
Drugs
Diseases
GWAS		Alzheimer's disease ( 24755620) Vitamin B12 levels ( 22367966)	Blood protein levels ( 30072576) Electroencephalogram traits ( 25387704)
Interacting Genes		38 interacting genes: ADIPOQ ARLN ATP6V0B BMP10 BNIP3 CCDC167 CD53 CD72 CDKN3 CLDN1 CLDN6 EFNA5 EMP3 ERG28 IFITM3 IGFBP5 MS4A13 NKG7 PLP1 PLPP6 SEC22A SGTA SLC22A14 SLC5A4 SMCO4 SMIM3 STX8 TEX264 TM4SF18 TMBIM6 TMEM107 TMEM140 TMEM182 TMEM218 TMEM239 VKORC1L1 YIPF6 ZFPL1	22 interacting genes: ATP6AP2 BIK BLNK CD5 CGRRF1 CLDN7 CREB3L1 GPR152 GRAMD1C GRB2 LHFPL5 LMNA LRRC25 LSMEM2 LYN MS4A3 MS4A7 NRG1 PTPN6 SEMA4D SPACA1 SYK
Entrez ID		932	971
HPRD ID		09403	00118
Ensembl ID		ENSG00000149516	ENSG00000137101
Uniprot IDs		Q96HJ5	P21854 Q5TLG3
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane	B Cell Receptor Signaling Pathway T Cell Costimulation Membrane Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Adhesion Phosphotyrosine Residue Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin SH2 Domain Binding Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Plasma Membrane Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Immune Response-activating Signaling Pathway Phosphorylation-dependent Protein Binding Negative Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Activation Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Neutrophil Activation Involved In Immune Response Regulation Of MAPK Cascade Negative Regulation Of Immune Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lymphocyte Activation Regulation Of Mast Cell Activation Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Phospholipase Binding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Cellular Component Biogenesis Regulation Of Lymphocyte Activation Regulation Of Cell-cell Adhesion SH3 Domain Binding Negative Regulation Of Defense Response Regulation Of ERK1 And ERK2 Cascade Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Chemorepellent Activity Ephrin Receptor Binding Neutrophil Activation
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