MS4A3 and CLDN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MS4A3	CLDN1
Description		membrane spanning 4-domains A3	claudin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Endomembrane System Membrane Specific Granule Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Protein-containing Complex Tight Junction Anchoring Junction
	Molecular Function	Protein Binding	Virus Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process		Cell Adhesion Establishment Of Blood-nerve Barrier Response To Toxic Substance Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Positive Regulation Of Cell Migration Response To Lipopolysaccharide Cell Junction Maintenance Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Response To Ethanol Symbiont Entry Into Host Cell Protein Complex Oligomerization Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Establishment Of Skin Barrier Xenobiotic Transport Across Blood-nerve Barrier Response To Interleukin-18 Bicellular Tight Junction Assembly Cellular Response To Lead Ion Cellular Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Response To Dexamethasone Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Wound Healing Establishment Of Endothelial Intestinal Barrier Liver Regeneration Positive Regulation Of Bicellular Tight Junction Assembly Cellular Response To Butyrate
Pathways		Neutrophil degranulation	Tight junction interactions
Drugs
Diseases			Neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome; Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC)
GWAS		Alzheimer's disease ( 24755620) Vitamin B12 levels ( 22367966)	Optic disc size ( 31809533) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		38 interacting genes: ADIPOQ ARLN ATP6V0B BMP10 BNIP3 CCDC167 CD53 CD72 CDKN3 CLDN1 CLDN6 EFNA5 EMP3 ERG28 IFITM3 IGFBP5 MS4A13 NKG7 PLP1 PLPP6 SEC22A SGTA SLC22A14 SLC5A4 SMCO4 SMIM3 STX8 TEX264 TM4SF18 TMBIM6 TMEM107 TMEM140 TMEM182 TMEM218 TMEM239 VKORC1L1 YIPF6 ZFPL1	18 interacting genes: BRD4 CD69 CD79A CLDN3 DRG1 FNDC9 LNX1 MMP14 MMP2 MPDZ MS4A3 PATJ TJP1 TJP2 TJP3 TMEM179B TMEM9 WNK4
Entrez ID		932	9076
HPRD ID		09403	04760
Ensembl ID		ENSG00000149516	ENSG00000163347
Uniprot IDs		Q96HJ5	A5JSJ9 O95832
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane	Bicellular Tight Junction Tight Junction Positive Regulation Of Blood-brain Barrier Permeability Cell-cell Junction Organization Maintenance Of Blood-brain Barrier Establishment Of Endothelial Barrier Anchoring Junction Endothelial Cell Development Regulation Of Blood-brain Barrier Permeability Cell Junction Organization Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Vascular Permeability Protein Localization To Cell-cell Junction Apical Junction Complex Cell-cell Junction Assembly Epithelial Cell Development Regulation Of Vascular Permeability Tight Junction Assembly Membrane Tight Junction Organization Anatomical Structure Homeostasis Tissue Homeostasis Protein Localization To Cell Junction Apical Part Of Cell Multicellular Organismal-level Homeostasis Cell Adhesion Molecule Binding Cell Junction Assembly Vascular Process In Circulatory System Cell-cell Junction Maintenance Apicolateral Plasma Membrane Circulatory System Process Plasma Membrane Regulation Of T-helper 17 Cell Differentiation Endodermal Cell Differentiation Regulation Of T-helper 17 Type Immune Response Collagen Catabolic Process Regulation Of Cell Adhesion Regulation Of Cell Fate Commitment Ovarian Follicle Development Extracellular Matrix Disassembly Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Cell Junction Histone H4K8ac Reader Activity Aldosterone Secretion Regulation Of T-helper Cell Differentiation Cell Junction Maintenance Regulation Of Lymphocyte Differentiation Homeostatic Process Transmembrane Signaling Receptor Activity
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