NFYC and KLF15

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NFYC	KLF15
Description		nuclear transcription factor Y subunit gamma	KLF transcription factor 15
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Intracellular Glucose Homeostasis Regulation Of Transcription By RNA Polymerase II Glial Cell Differentiation Regulation Of Gene Expression Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Wnt Signaling Pathway Response To Insulin Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Negative Regulation Of Transforming Growth Factor Beta Production Podocyte Differentiation Cellular Response To Endothelin Negative Regulation Of Peptidyl-lysine Acetylation
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes	BMAL1:CLOCK,NPAS2 activates circadian expression
Drugs
Diseases
GWAS		Adult body size ( 32376654) Airway obstruction (FEV1/FVC<70%) in never smokers ( 30845926) Airway obstruction (FEV1/FVC<lower limit of normal) in never smokers ( 30845926) Depressive and manic episodes in bipolar disorder ( 26297903) Platelet count ( 21507922) Refractive error ( 32231278)	Macular telangiectasia type 2 ( 28250457) Male-pattern baldness ( 28196072) Manganese levels ( 26025379) Metabolite levels ( 23378610) Refractive error ( 32231278) Urate levels ( 31578528)
Interacting Genes		65 interacting genes: ADGRF5 ADNP2 APOL4 ARID2 ATF6 ATF6B BDH2 BICRA BICRAL CEP76 CIART CIC CRX CSN2 CXorf38 DR1 DST ELF1 FAM168A GAPDH HGS HSFY1 HSFY2 KLF11 KLF15 KLHDC7B LIN54 LMO4 MYC NFYA NFYB NUTM2F OSTF1 PAX4 PAX5 PAX6 POGZ POU3F2 POU6F1 POU6F2 PRR20B PRR20C PRR20D PRR20E RAD52 SAE1 SMAD2 SMAD3 SMAP1 SNX2 SP1 SP2 SP4 SREBF2 STOX1 TAF11 TAF12 TAF6 TBP UBXN7 USF3 ZDHHC17 ZMYM6 ZNF34 ZSCAN1	24 interacting genes: AIRIM ANKS1A APPL1 BANP C11orf68 CCDC57 CRK DVL3 HNRNPF KBTBD7 NFYC NRF1 PIK3R3 POLR1C PRKAB2 SCNM1 SHFL SNX13 STAT3 SUV39H1 TCF21 ZBTB24 ZNF330 ZNF76
Entrez ID		4802	28999
HPRD ID		05633	07568
Ensembl ID		ENSG00000066136	ENSG00000163884
Uniprot IDs		Q13952	Q9UIH9
PDB IDs		1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS 7AH8 8QU2 8QU3 8QU4	2ENT
Enriched GO Terms of Interacting Partners?		Chromatin DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Protein-DNA Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Sequence-specific DNA Binding Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription R-SMAD Binding Transcription Preinitiation Complex Assembly Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription DNA-binding Transcription Factor Binding Transcription Factor TFIID Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of MiRNA Transcription Co-SMAD Binding Regulation Of MiRNA Metabolic Process
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