NFYC and ATF6

Number of citations of the paper that reports this interaction (PMID 11158310)
58

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vitro, two hybrid)

		NFYC	ATF6
Gene Name		nuclear transcription factor Y, gamma	activating transcription factor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding CAMP Response Element Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Folding Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Folding Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins ATF4 activates genes ATF6-alpha activates chaperone genes Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) PERK regulates gene expression ATF6-alpha activates chaperones Unfolded Protein Response (UPR)	ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperone genes ATF6-alpha activates chaperones Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Platelet counts ( 21507922)	Parkinson's disease (age of onset) ( 19772629)
Protein-Protein Interactions		27 interactors: ADNP2 ARID2 ATF6 ATF6B CIC CSN2 DR1 DST GAPDH GLTSCR1 GLTSCR1L KIAA2018 LMO4 MYC NFYA NFYB POGZ SMAD2 SMAD3 SNX2 SP1 SREBF2 TAF11 TAF12 TAF6 TBP ZDHHC17	14 interactors: APP ATF6B BPGM CREB1 CREB3L3 DDC GTF2I NFYA NFYC NNMT SRF TNFRSF1A XBP1 YY1
Entrez ID		4802	22926
HPRD ID		05633	16118
Ensembl ID		ENSG00000066136	ENSG00000118217
Uniprot IDs		Q13952	A8K383 P18850
PDB IDs		1N1J 4AWL
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Gene Expression Biosynthetic Process Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Primary MiRNA Processing Viral Process Regulation Of Nodal Signaling Pathway Cellular Metabolic Process SMAD Protein Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Paraxial Mesoderm Morphogenesis Positive Regulation By Host Of Viral Transcription Positive Regulation Of Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Cellular Response To Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Topologically Incorrect Protein Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Response To Unfolded Protein Response To Organonitrogen Compound Response To Endoplasmic Reticulum Stress Cellular Response To Stimulus Response To Toxic Substance Response To Hormone Small Molecule Metabolic Process Response To Drug Cellular Chemical Homeostasis Response To Stress Response To Abiotic Stimulus Erythrocyte Development Cellular Response To Nutrient Regulation Of Metabolic Process Positive Regulation Of Fat Cell Differentiation
Tagcloud ?		associates attempt blastocyst cdc25a cdc42 egg embryonal esg1 exist forced icm immediately immunoprecipitated inner kh notion nr5a2 oct3 overlap pluripotency polar pou5f1 preimplantation supporting te transcript transcriptase transcripts trophectoderm	ca1 ca3 cerebellar cerebellum colliculus dentate developmentally germinal grp78 grp94 gyrus immature inducer insults manf matured misfolded neurodevelopmental parietal pd12 pd25 pd4 pons subcutaneously subiculum tunicamycin unfolded upr xbp1s
Tagcloud (Difference) ?		associates attempt blastocyst cdc25a cdc42 egg embryonal esg1 exist forced icm immediately immunoprecipitated inner kh notion nr5a2 oct3 overlap pluripotency polar pou5f1 preimplantation supporting te transcript transcriptase transcripts trophectoderm	ca1 ca3 cerebellar cerebellum colliculus dentate developmentally germinal grp78 grp94 gyrus immature inducer insults manf matured misfolded neurodevelopmental parietal pd12 pd25 pd4 pons subcutaneously subiculum tunicamycin unfolded upr xbp1s
Tagcloud (Intersection) ?