NFYC and DR1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NFYC	DR1
Name		nuclear transcription factor Y subunit gamma	down-regulator of transcription 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Negative Cofactor 2 Complex Mitotic Spindle RNA Polymerase II Transcription Regulator Complex ATAC Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Heterodimerization Activity General Transcription Initiation Factor Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development RNA Polymerase II Preinitiation Complex Assembly Regulation Of Cell Division Regulation Of Cell Cycle
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes	HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
GWAS		Adult body size ( 32376654 ) Airway obstruction (FEV1/FVC<70%) in never smokers ( 30845926 ) Airway obstruction (FEV1/FVC<lower limit of normal) in never smokers ( 30845926 ) Depressive and manic episodes in bipolar disorder ( 26297903 ) Platelet count ( 21507922 ) Refractive error ( 32231278 )	Alanine aminotransferase levels ( 33547301 ) Apolipoprotein A1 levels ( 32203549 ) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189 ) HDL cholesterol levels ( 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) High density lipoprotein cholesterol levels ( 33339817 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Mean spheric corpuscular volume ( 32888494 ) Metabolic syndrome ( 31589552 ) Red blood cell count ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Triglyceride levels ( 32203549 33339817 29403010 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Urate levels ( 31578528 )
Novel Interactors		2 novel interactors: JAK1 JUN	None recorded
Interacting Genes		65 interacting genes: ADGRF5 ADNP2 APOL4 ARID2 ATF6 ATF6B BDH2 BICRA BICRAL CEP76 CIART CIC CRX CSN2 CXorf38 DR1 DST ELF1 FAM168A GAPDH HGS HSFY1 HSFY2 KLF11 KLF15 KLHDC7B LIN54 LMO4 MYC NFYA NFYB NUTM2F OSTF1 PAX4 PAX5 PAX6 POGZ POU3F2 POU6F1 POU6F2 PRR20B PRR20C PRR20D PRR20E RAD52 SAE1 SMAD2 SMAD3 SMAP1 SNX2 SP1 SP2 SP4 SREBF2 STOX1 TAF11 TAF12 TAF6 TBP UBXN7 USF3 ZDHHC17 ZMYM6 ZNF34 ZSCAN1	8 interacting genes: DNMT3L DRAP1 NFIL3 NFYC POLE3 TBP XPO1 ZDHHC17
Entrez ID		4802	1810
HPRD ID		05633	03284
Ensembl ID		ENSG00000066136	ENSG00000117505
Uniprot IDs		Q13952	Q01658 Q658N3
PDB IDs		1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS 7AH8 8QU2 8QU3 8QU4	1JFI
GO Terms Enriched among Interactors		Chromatin DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Protein-DNA Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Sequence-specific DNA Binding Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription R-SMAD Binding Transcription Preinitiation Complex Assembly Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription DNA-binding Transcription Factor Binding Transcription Factor TFIID Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of MiRNA Transcription Co-SMAD Binding Regulation Of MiRNA Metabolic Process	RNA Polymerase II General Transcription Initiation Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Core Promoter Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Protein Heterodimerization Activity Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Chromatin Cellular Response To Triglyceride Negative Cofactor 2 Complex Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Programing Of Female Pronucleus Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process TFIIB-class Transcription Factor Binding Response To Triglyceride Heterochromatin Formation CHRAC Leading Strand Elongation CCAAT-binding Factor Complex RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIIA Complex Annulate Lamellae Protein-cysteine S-myristoyltransferase Activity Negative Regulation Of Heterochromatin Formation Epsilon DNA Polymerase Complex Negative Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process Cellular Response To Salt Ribosomal Large Subunit Export From Nucleus Protein-cysteine S-stearoyltransferase Activity