NFYC and POU6F1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NFYC	POU6F1
Description		nuclear transcription factor Y subunit gamma	POU class 6 homeobox 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Heart Development Muscle Organ Development
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Adult body size ( 32376654) Airway obstruction (FEV1/FVC<70%) in never smokers ( 30845926) Airway obstruction (FEV1/FVC<lower limit of normal) in never smokers ( 30845926) Depressive and manic episodes in bipolar disorder ( 26297903) Platelet count ( 21507922) Refractive error ( 32231278)	Adult body size ( 32376654) Cisplatin-induced ototoxicity ( 28039263) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		65 interacting genes: ADGRF5 ADNP2 APOL4 ARID2 ATF6 ATF6B BDH2 BICRA BICRAL CEP76 CIART CIC CRX CSN2 CXorf38 DR1 DST ELF1 FAM168A GAPDH HGS HSFY1 HSFY2 KLF11 KLF15 KLHDC7B LIN54 LMO4 MYC NFYA NFYB NUTM2F OSTF1 PAX4 PAX5 PAX6 POGZ POU3F2 POU6F1 POU6F2 PRR20B PRR20C PRR20D PRR20E RAD52 SAE1 SMAD2 SMAD3 SMAP1 SNX2 SP1 SP2 SP4 SREBF2 STOX1 TAF11 TAF12 TAF6 TBP UBXN7 USF3 ZDHHC17 ZMYM6 ZNF34 ZSCAN1	3 interacting genes: ACOT7 ERBB2 NFYC
Entrez ID		4802	5463
HPRD ID		05633	17883
Ensembl ID		ENSG00000066136	ENSG00000184271
Uniprot IDs		Q13952	B3KT91 Q14863
PDB IDs		1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS 7AH8 8QU2 8QU3 8QU4	3D1N
Enriched GO Terms of Interacting Partners?		Chromatin DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Protein-DNA Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Sequence-specific DNA Binding Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription R-SMAD Binding Transcription Preinitiation Complex Assembly Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription DNA-binding Transcription Factor Binding Transcription Factor TFIID Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of MiRNA Transcription Co-SMAD Binding Regulation Of MiRNA Metabolic Process	Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway CCAAT-binding Factor Complex Long-chain Fatty Acyl-CoA Binding Medium-chain Fatty Acid Biosynthetic Process Medium-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty-acyl-CoA Catabolic Process Palmitic Acid Biosynthetic Process Fatty-acyl-CoA Catabolic Process Medium-chain Fatty-acyl-CoA Metabolic Process Negative Regulation Of Immature T Cell Proliferation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-EGFR Signaling Pathway Protein Heterodimerization Activity ERBB4 Signaling Pathway Thiolester Hydrolase Activity Medium-chain Fatty Acid Metabolic Process Coenzyme A Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Semaphorin Receptor Complex Regulation Of Immature T Cell Proliferation In Thymus Long-chain Fatty Acyl-CoA Hydrolase Activity Fatty-acyl-CoA Binding Coenzyme A Metabolic Process Fatty Acyl-CoA Hydrolase Activity Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Motor Neuron Axon Guidance Peripheral Nervous System Development Regulation Of T Cell Differentiation In Thymus ERBB2 Signaling Pathway Positive Regulation Of Protein Targeting To Membrane Long-chain Fatty-acyl-CoA Metabolic Process Positive Regulation Of Rho Protein Signal Transduction Protein Localization To Postsynapse Regulation Of Protein Targeting To Membrane Protein Localization To Postsynaptic Membrane Positive Regulation Of Transcription By RNA Polymerase I Myelin Sheath Positive Regulation Of MAP Kinase Activity Neuromuscular Junction Development Long-chain Fatty Acid Biosynthetic Process Carboxylic Ester Hydrolase Activity Oligodendrocyte Differentiation Regulation Of Transcription By RNA Polymerase I
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