NFYC and RAD52

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NFYC	RAD52
Name		nuclear transcription factor Y subunit gamma	RAD52 DNA repair protein
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	DNA Binding Single-stranded DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Repair Double-strand Break Repair DNA Recombination Mitotic Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To Oxidative Stress Double-strand Break Repair Via Single-strand Annealing Regulation Of Nucleotide-excision Repair
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes	SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ)
GWAS		Adult body size ( 32376654 ) Airway obstruction (FEV1/FVC<70%) in never smokers ( 30845926 ) Airway obstruction (FEV1/FVC<lower limit of normal) in never smokers ( 30845926 ) Depressive and manic episodes in bipolar disorder ( 26297903 ) Platelet count ( 21507922 ) Refractive error ( 32231278 )	Body mass index ( 26426971 ) Eosinophil percentage of granulocytes ( 27863252 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Lung cancer ( 22899653 ) Neutrophil percentage of granulocytes ( 27863252 ) Small cell lung carcinoma ( 28604730 ) Systolic blood pressure ( 30224653 30578418 ) Youthful appearance (self-reported) ( 32339537 )
Interacting Genes		65 interacting genes: ADGRF5 ADNP2 APOL4 ARID2 ATF6 ATF6B BDH2 BICRA BICRAL CEP76 CIART CIC CRX CSN2 CXorf38 DR1 DST ELF1 FAM168A GAPDH HGS HSFY1 HSFY2 KLF11 KLF15 KLHDC7B LIN54 LMO4 MYC NFYA NFYB NUTM2F OSTF1 PAX4 PAX5 PAX6 POGZ POU3F2 POU6F1 POU6F2 PRR20B PRR20C PRR20D PRR20E RAD52 SAE1 SMAD2 SMAD3 SMAP1 SNX2 SP1 SP2 SP4 SREBF2 STOX1 TAF11 TAF12 TAF6 TBP UBXN7 USF3 ZDHHC17 ZMYM6 ZNF34 ZSCAN1	25 interacting genes: ABL1 AURKB DCP1A ERCC1 ERCC2 ERCC3 ERCC4 KPNA3 KPNA5 MCM2 MCM3 MEOX1 MEOX2 NFYC PAX5 PLK3 RAD51 RDM1 RPA1 RPA2 SEM1 SUMO1 TTK UBE2I WRN
Entrez ID		4802	5893
HPRD ID		05633	11855
Ensembl ID		ENSG00000066136	ENSG00000002016
Uniprot IDs		Q13952	B7Z2G8 B7Z5Q6 F5GX32 P43351 Q5DR82
PDB IDs		1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS 7AH8 8QU2 8QU3 8QU4	1H2I 1KN0 5JRB 5XRZ 5XS0 8BJM 8H1P 8RIL 8RJ3 8RJW 8TKQ
GO Terms Enriched among Interactors		Chromatin DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Protein-DNA Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Sequence-specific DNA Binding Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription R-SMAD Binding Transcription Preinitiation Complex Assembly Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription DNA-binding Transcription Factor Binding Transcription Factor TFIID Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of MiRNA Transcription Co-SMAD Binding Regulation Of MiRNA Metabolic Process	DNA Repair DNA Damage Response DNA Metabolic Process Nucleus Double-strand Break Repair Recombinational Repair Double-strand Break Repair Via Homologous Recombination DNA Recombination Chromosome, Telomeric Region Nucleotide-excision Repair Single-stranded DNA Binding Damaged DNA Binding Regulation Of DNA Metabolic Process DNA Binding UV Protection Nucleoplasm Cellular Response To Stress Telomere Maintenance Protein Localization To Organelle PML Body Nucleic Acid Metabolic Process Chromosome Organization Telomere Organization Mismatch Repair Response To UV Response To Radiation DNA Helicase Activity Nucleobase-containing Compound Metabolic Process 3'-5' DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Maintenance Via Recombination Helicase Activity ATP Binding DNA Replication Repair Of Mitotic Kinetochore Microtubule Attachment Defect DNA Conformation Change Single-stranded DNA Helicase Activity Regulation Of Cell Cycle Phase Transition Mitotic Recombination Cellular Response To Radiation Regulation Of Mitotic Cell Cycle Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Response To Light Stimulus Negative Regulation Of Protection From Non-homologous End Joining At Telomere Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Nucleotide Binding Response To Oxidative Stress