NFYC and BICRA

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		NFYC	BICRA
Description		nuclear transcription factor Y subunit gamma	BRD4 interacting chromatin remodeling complex associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus SWI/SNF Complex GBAF Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	Protein Binding Transcription Regulator Activator Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Stem Cell Population Maintenance
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes	Formation of the non-canonical BAF (ncBAF) complex
Drugs
Diseases
GWAS		Adult body size ( 32376654) Airway obstruction (FEV1/FVC<70%) in never smokers ( 30845926) Airway obstruction (FEV1/FVC<lower limit of normal) in never smokers ( 30845926) Depressive and manic episodes in bipolar disorder ( 26297903) Platelet count ( 21507922) Refractive error ( 32231278)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		65 interacting genes: ADGRF5 ADNP2 APOL4 ARID2 ATF6 ATF6B BDH2 BICRA BICRAL CEP76 CIART CIC CRX CSN2 CXorf38 DR1 DST ELF1 FAM168A GAPDH HGS HSFY1 HSFY2 KLF11 KLF15 KLHDC7B LIN54 LMO4 MYC NFYA NFYB NUTM2F OSTF1 PAX4 PAX5 PAX6 POGZ POU3F2 POU6F1 POU6F2 PRR20B PRR20C PRR20D PRR20E RAD52 SAE1 SMAD2 SMAD3 SMAP1 SNX2 SP1 SP2 SP4 SREBF2 STOX1 TAF11 TAF12 TAF6 TBP UBXN7 USF3 ZDHHC17 ZMYM6 ZNF34 ZSCAN1	2 interacting genes: CRK NFYC
Entrez ID		4802	29998
HPRD ID		05633	09296
Ensembl ID		ENSG00000066136	ENSG00000063169
Uniprot IDs		Q13952	Q9NZM4
PDB IDs		1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS 7AH8 8QU2 8QU3 8QU4
Enriched GO Terms of Interacting Partners?		Chromatin DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Protein-DNA Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Sequence-specific DNA Binding Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription R-SMAD Binding Transcription Preinitiation Complex Assembly Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription DNA-binding Transcription Factor Binding Transcription Factor TFIID Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of MiRNA Transcription Co-SMAD Binding Regulation Of MiRNA Metabolic Process	Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Cerebellar Neuron Development Response To Hepatocyte Growth Factor Cellular Response To Nitric Oxide Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Diapedesis Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Insulin-like Growth Factor Receptor Binding Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Reelin-mediated Signaling Pathway Cellular Response To Reactive Nitrogen Species Response To Endothelin Response To Yeast Cellular Response To Endothelin Postsynaptic Specialization Assembly CCAAT-binding Factor Complex Positive Regulation Of Rac Protein Signal Transduction Response To Nitric Oxide Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Postsynaptic Specialization Organization Ephrin Receptor Binding Signaling Receptor Complex Adaptor Activity Response To Nerve Growth Factor Dendrite Development SH2 Domain Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Central Nervous System Neuron Development Protein Tyrosine Kinase Binding Regulation Of Rac Protein Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration T Cell Migration Cellular Response To Nerve Growth Factor Stimulus Protein-DNA Complex Phosphotyrosine Residue Binding Regulation Of T Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Ephrin Receptor Signaling Pathway Lymphocyte Migration Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Fungus Cellular Response To Transforming Growth Factor Beta Stimulus Receptor Tyrosine Kinase Binding Regulation Of Smooth Muscle Cell Migration Cytoskeletal Protein Binding
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