NFYB and DRAP1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		NFYB	DRAP1
Gene Name		nuclear transcription factor Y, beta	DR1-associated protein 1 (negative cofactor 2 alpha)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex	Nucleus
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Complex Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins ATF4 activates genes ATF6-alpha activates chaperone genes Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) PERK regulates gene expression ATF6-alpha activates chaperones Unfolded Protein Response (UPR)	Signaling by Activin Signaling by NODAL
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: AGTRAP C1QBP CEBPZ CIITA CNTN2 DRAP1 ELF1 EP300 GRB2 MAOB MYC NFYA NFYC POLE4 SMYD3 SP1 TAF11 TAF12 TAF6 TBP TP53 TP73 YBX1 YBX3	22 interactors: APP ARHGEF10L CDKN2C DNAJB11 DR1 FEZ1 FEZ2 FOXH1 GTF2B LMO2 NCK2 NFYB PIK3R3 POLE3 SRPK2 TAF9 TAF9B TBP TK1 TNFRSF14 TTF2 ZEB1
Entrez ID		4801	10589
HPRD ID		01794	03796
Ensembl ID		ENSG00000120837	ENSG00000175550
Uniprot IDs		P25208	Q14919
PDB IDs		1N1J 4AWL	1JFI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Viral Process Cellular Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation By Host Of Viral Transcription Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Interaction With Symbiont Negative Regulation Of Signal Transduction Cellular Response To Radiation Negative Regulation Of Signaling Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Elongation Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription, DNA-templated Gene Expression Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cellular Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Viral Process Histone Acetylation Regulation Of Receptor Activity Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Internal Protein Amino Acid Acetylation Response To Organic Substance Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Acetylation Negative Regulation Of Transcription, DNA-templated Regulation Of Epidermal Growth Factor-activated Receptor Activity
Tagcloud ?		attenuates behave caf ccaat competes concordance conversely counteracts deacetylase deltanp73 deltanp73alpha detecting exist hdac hdac1 immunofluorescence motif nih3t3 p73 p73alpha pdgfrb periods repression starved supporting tap73 trichostatin yc
Tagcloud (Difference) ?		attenuates behave caf ccaat competes concordance conversely counteracts deacetylase deltanp73 deltanp73alpha detecting exist hdac hdac1 immunofluorescence motif nih3t3 p73 p73alpha pdgfrb periods repression starved supporting tap73 trichostatin yc
Tagcloud (Intersection) ?