NFYB and CNTN2

Number of citations: 91 (PubMedID 9032250)
Data Source: HPRD (two hybrid, in vivo)

		NFYB	CNTN2
Name		nuclear transcription factor Y subunit beta	contactin 2
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Plasma Membrane Cell Surface Membrane Axon Node Of Ranvier Neuron Projection Neuronal Cell Body Axon Initial Segment Myelin Sheath Juxtaparanode Region Of Axon Synapse Postsynaptic Membrane Side Of Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding	Protein Binding Carbohydrate Binding Cell Adhesion Mediator Activity Cell-cell Adhesion Mediator Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Leukemia Inhibitory Factor	Microtubule Cytoskeleton Organization Neuron Migration G Protein-coupled Adenosine Receptor Signaling Pathway Response To Dietary Excess Reduction Of Food Intake In Response To Dietary Excess Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Axonal Fasciculation Learning Adult Walking Behavior Positive Regulation Of Protein Processing Protein Processing Cerebral Cortex GABAergic Interneuron Migration Central Nervous System Neuron Differentiation Central Nervous System Myelination Regulation Of Cell Morphogenesis Regulation Of Axon Diameter Neuron Projection Development Receptor Internalization Clustering Of Voltage-gated Potassium Channels Fat Cell Differentiation Negative Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Astrocyte Differentiation Synapse Organization Establishment Of Localization In Cell Positive Regulation Of Adenosine Receptor Signaling Pathway Dendrite Self-avoidance Protein Localization To Juxtaparanode Region Of Axon Establishment Of Protein Localization To Juxtaparanode Region Of Axon Presynaptic Membrane Organization
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes	L1CAM interactions NCAM1 interactions NrCAM interactions
GWAS		Toenail selenium levels ( 25343990 )	Adventurousness ( 30643258 ) Aspartate aminotransferase levels ( 33547301 ) Blood protein levels ( 30072576 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) HDL cholesterol levels ( 32203549 ) Mean platelet volume ( 24026423 ) Meat-related diet ( 32066663 ) Number of sexual partners ( 30643258 ) Periodontitis (stage III/IV grade C) ( 33745150 ) Red blood cell count ( 27863252 ) Schizophrenia ( 30285260 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		1 novel interactors: DUSP6	1 novel interactors: NEK2
Interacting Genes		26 interacting genes: AGTRAP C1QBP CEBPZ CIITA CNTN2 DRAP1 ELF1 EP300 GRB2 MAOB MEOX2 MYC NFYA NFYC POLE4 POU3F2 SMYD3 SP1 TAF11 TAF12 TAF6 TBP TP53 TP73 YBX1 YBX3	12 interacting genes: CDK4 CHEK1 CNTN1 CNTNAP2 EGFR L1CAM NCAN NFYB NRCAM TUBG1 UBE4B VAC14
Entrez ID		4801	6900
HPRD ID		01794	01826
Ensembl ID		ENSG00000120837	ENSG00000184144
Uniprot IDs		F8VSL3 P25208	A1L3A3 Q02246
PDB IDs		1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS 7AH8 8QU2 8QU3 8QU4	2OM5 8K3J 8K53 9BA4 9BA5
GO Terms Enriched among Interactors		Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Transcription By RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Nucleoplasm CCAAT-binding Factor Complex MRNA Transcription Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Transcription Factor TFIID Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA-binding Transcription Factor Binding Nucleus Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity Protein-DNA Complex Protein Heterodimerization Activity MRNA Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly Regulation Of Cellular Response To Stress Transcription Preinitiation Complex Assembly Transcription Cis-regulatory Region Binding Host-mediated Activation Of Viral Transcription Nucleic Acid Metabolic Process	Condensed Nuclear Chromosome Regulation Of Mitotic Centrosome Separation Neuron Projection Development Cell Adhesion Neuronal Ion Channel Clustering Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Axon Central Nervous System Development Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Cell-cell Adhesion Mediator Activity Plasma Membrane Bounded Cell Projection Organization Regulation Of Mitotic Cell Cycle Protein Kinase Activity Cell-cell Adhesion Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Neuron Projection Guidance Axon Guidance Neuron Recognition Brain Development Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Centriole-centriole Cohesion Nuclear Chromosome Segregation Granzyme-mediated Apoptotic Signaling Pathway PAS Complex Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Process Kinase Activity Cell Projection Organization Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Ciliary Basal Body Shc-EGFR Complex Microtubule Nucleator Activity Limbic System Development Superior Temporal Gyrus Development Regulation Of Axon Extension Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D2-CDK4 Complex Protein Serine Kinase Activity Regulation Of Fibroblast Proliferation Histone H3T11 Kinase Activity Protein Phosphatase Binding Positive Regulation Of Protein Kinase C Signaling