NFYB and POLE4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NFYB	POLE4
Description		nuclear transcription factor Y subunit beta	DNA polymerase epsilon 4, accessory subunit
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex ATAC Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Leukemia Inhibitory Factor	DNA-templated DNA Replication DNA Biosynthetic Process
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS		Toenail selenium levels ( 25343990)	Venous thromboembolism ( 33592630)
Interacting Genes		26 interacting genes: AGTRAP C1QBP CEBPZ CIITA CNTN2 DRAP1 ELF1 EP300 GRB2 MAOB MEOX2 MYC NFYA NFYC POLE4 POU3F2 SMYD3 SP1 TAF11 TAF12 TAF6 TBP TP53 TP73 YBX1 YBX3	7 interacting genes: HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B UBE3A
Entrez ID		4801	56655
HPRD ID		01794	16238
Ensembl ID		ENSG00000120837	ENSG00000115350
Uniprot IDs		F8VSL3 P25208	Q9NR33
PDB IDs		1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS 7AH8 8QU2 8QU3 8QU4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Transcription By RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Nucleoplasm CCAAT-binding Factor Complex MRNA Transcription Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Transcription Factor TFIID Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA-binding Transcription Factor Binding Nucleus Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity Protein-DNA Complex Protein Heterodimerization Activity MRNA Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly Regulation Of Cellular Response To Stress Transcription Preinitiation Complex Assembly Transcription Cis-regulatory Region Binding Host-mediated Activation Of Viral Transcription Nucleic Acid Metabolic Process	Epsilon DNA Polymerase Complex DNA-directed DNA Polymerase Activity Leading Strand Elongation DNA-templated DNA Replication DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication DNA Synthesis Involved In DNA Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Lactosylceramide Biosynthetic Process
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