ITPK1

Gene Name		inositol-tetrakisphosphate 1-kinase
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Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Magnesium Ion Binding Catalytic Activity ATP Binding Isomerase Activity Inositol Tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity Inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase Activity Inositol-1,3,4,6-tetrakisphosphate 6-phosphatase Activity Inositol-1,3,4,6-tetrakisphosphate 1-phosphatase Activity Inositol-3,4,6-trisphosphate 1-kinase Activity
	Biological Process	Signal Transduction Blood Coagulation Phosphorylation Dephosphorylation Inositol Trisphosphate Metabolic Process Inositol Phosphate Metabolic Process Small Molecule Metabolic Process
Pathways		Synthesis of IP3 and IP4 in the cytosol Synthesis of pyrophosphates in the cytosol Factors involved in megakaryocyte development and platelet production Inositol phosphate metabolism
Drugs
Diseases
GWAS		Endometriosis ( 23472165) Platelet counts ( 22139419) Thyroid hormone levels ( 23408906)
Protein-protein Interactions		6 interactors: COPS8 GPS1 JUN NFKBIA TP53 TRAF2
Entrez ID		3705
HPRD ID		03501
Ensembl ID		ENSG00000100605
Uniprot IDs		Q13572
PDB IDs		2ODT 2Q7D 2QB5
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Phosphorylation Cullin Deneddylation Toll-like Receptor Signaling Pathway Protein Import Into Nucleus Nuclear Import Protein Deneddylation Regulation Of Signal Transduction Regulation Of Phosphorylation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Import Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Protein Localization To Nucleus Positive Regulation Of Innate Immune Response Activation Of NF-kappaB-inducing Kinase Activity Protein Import Into Nucleus, Translocation Release Of Cytochrome C From Mitochondria Regulation Of Innate Immune Response Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Binding Nucleocytoplasmic Transport Nuclear Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Neuron Death NIK/NF-kappaB Signaling Apoptotic Process Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Cell Death Programmed Necrotic Cell Death Programmed Cell Death Necrotic Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Death Death Negative Regulation Of DNA Binding Regulation Of Catalytic Activity Establishment Of Protein Localization To Organelle Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		acetylated acetylation acetyltransferases alters catalyzes creb deacetylation dramatically enzyme expressing forms functionally hek293 inositol internal limiting lysine lysines mammalian modification phosphorylated posttranslational silent sits spectrometry stability stably trisphosphate unacetylated