ITPK1 and COPS8

Number of citations of the paper that reports this interaction (PMID 12324474)
21

Data Source:
HPRD (in vitro)

		ITPK1	COPS8
Gene Name		inositol-tetrakisphosphate 1-kinase	COP9 signalosome subunit 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Catalytic Activity ATP Binding Isomerase Activity Inositol Tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity Inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase Activity Inositol-1,3,4,6-tetrakisphosphate 6-phosphatase Activity Inositol-1,3,4,6-tetrakisphosphate 1-phosphatase Activity Inositol-3,4,6-trisphosphate 1-kinase Activity
	Biological Process	Signal Transduction Blood Coagulation Phosphorylation Dephosphorylation Inositol Trisphosphate Metabolic Process Inositol Phosphate Metabolic Process Small Molecule Metabolic Process	Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Proliferation Cullin Deneddylation
Pathways		Synthesis of IP3 and IP4 in the cytosol Synthesis of pyrophosphates in the cytosol Factors involved in megakaryocyte development and platelet production Inositol phosphate metabolism
Drugs
Diseases
GWAS		Endometriosis ( 23472165) Platelet counts ( 22139419) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		6 interactors: COPS8 GPS1 JUN NFKBIA TP53 TRAF2	17 interactors: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 DDB1 EIF3E GPS1 ITPK1 JUN MAPRE1 NFKBIA TP53 USHBP1
Entrez ID		3705	10920
HPRD ID		03501	16737
Ensembl ID		ENSG00000100605
Uniprot IDs		Q13572	Q99627
PDB IDs		2ODT 2Q7D 2QB5
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Phosphorylation Cullin Deneddylation Toll-like Receptor Signaling Pathway Protein Import Into Nucleus Nuclear Import Protein Deneddylation Regulation Of Signal Transduction Regulation Of Phosphorylation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Import Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Protein Localization To Nucleus Positive Regulation Of Innate Immune Response Activation Of NF-kappaB-inducing Kinase Activity Protein Import Into Nucleus, Translocation Release Of Cytochrome C From Mitochondria Regulation Of Innate Immune Response Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Binding Nucleocytoplasmic Transport Nuclear Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Neuron Death NIK/NF-kappaB Signaling Apoptotic Process Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Cell Death Programmed Necrotic Cell Death Programmed Cell Death Necrotic Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Death Death Negative Regulation Of DNA Binding Regulation Of Catalytic Activity Establishment Of Protein Localization To Organelle Positive Regulation Of Cellular Protein Metabolic Process	Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Viral Process Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Cell Cycle Response To Abiotic Stimulus Protein Import Into Nucleus Apoptotic Signaling Pathway Nuclear Import Cell Proliferation Cell Cycle Arrest Protein Metabolic Process Protein Import Protein Import Into Nucleus, Translocation Release Of Cytochrome C From Mitochondria Cellular Macromolecule Catabolic Process Protein Localization To Nucleus Response To Radiation Circadian Rhythm Interaction With Symbiont Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Protein Localization To Organelle Modification-dependent Protein Catabolic Process Apoptotic Process Protein Monoubiquitination Programmed Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cell Death Negative Regulation Of DNA Binding Death Signal Transduction Toll-like Receptor 5 Signaling Pathway Protein Catabolic Process Toll-like Receptor 10 Signaling Pathway Regulation Of Binding Mitotic Cell Cycle Phase Transition Nucleocytoplasmic Transport Cell Cycle Phase Transition Nuclear Transport Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Response To UV Cellular Response To Potassium Ion Starvation Positive Regulation Of Neuron Apoptotic Process Toll-like Receptor 2 Signaling Pathway
Tagcloud ?		acetylated acetylation acetyltransferases alters catalyzes creb deacetylation dramatically enzyme expressing forms functionally hek293 inositol internal limiting lysine lysines mammalian modification phosphorylated posttranslational silent sits spectrometry stability stably trisphosphate unacetylated
Tagcloud (Difference) ?		acetylated acetylation acetyltransferases alters catalyzes creb deacetylation dramatically enzyme expressing forms functionally hek293 inositol internal limiting lysine lysines mammalian modification phosphorylated posttranslational silent sits spectrometry stability stably trisphosphate unacetylated
Tagcloud (Intersection) ?