ITPK1 and GPS1

Number of citations of the paper that reports this interaction (PMID 12324474)
21

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		ITPK1	GPS1
Gene Name		inositol-tetrakisphosphate 1-kinase	G protein pathway suppressor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm COP9 Signalosome
	Molecular Function	Magnesium Ion Binding Catalytic Activity ATP Binding Isomerase Activity Inositol Tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity Inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase Activity Inositol-1,3,4,6-tetrakisphosphate 6-phosphatase Activity Inositol-1,3,4,6-tetrakisphosphate 1-phosphatase Activity Inositol-3,4,6-trisphosphate 1-kinase Activity	GTPase Inhibitor Activity Protein Binding
	Biological Process	Signal Transduction Blood Coagulation Phosphorylation Dephosphorylation Inositol Trisphosphate Metabolic Process Inositol Phosphate Metabolic Process Small Molecule Metabolic Process	Inactivation Of MAPK Activity Cell Cycle JNK Cascade Cullin Deneddylation
Pathways		Synthesis of IP3 and IP4 in the cytosol Synthesis of pyrophosphates in the cytosol Factors involved in megakaryocyte development and platelet production Inositol phosphate metabolism
Drugs
Diseases
GWAS		Endometriosis ( 23472165) Platelet counts ( 22139419) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		6 interactors: COPS8 GPS1 JUN NFKBIA TP53 TRAF2	20 interactors: COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL1 CUL2 CUL3 CUL5 DDB1 IP6K1 ITPK1 JUN RBX1 SENP8 SKP1 SKP2 TBC1D17 TP53
Entrez ID		3705	2873
HPRD ID		03501	15991
Ensembl ID		ENSG00000100605	ENSG00000169727
Uniprot IDs		Q13572	C9JFE4 Q13098
PDB IDs		2ODT 2Q7D 2QB5
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Phosphorylation Cullin Deneddylation Toll-like Receptor Signaling Pathway Protein Import Into Nucleus Nuclear Import Protein Deneddylation Regulation Of Signal Transduction Regulation Of Phosphorylation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Import Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Protein Localization To Nucleus Positive Regulation Of Innate Immune Response Activation Of NF-kappaB-inducing Kinase Activity Protein Import Into Nucleus, Translocation Release Of Cytochrome C From Mitochondria Regulation Of Innate Immune Response Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Binding Nucleocytoplasmic Transport Nuclear Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Neuron Death NIK/NF-kappaB Signaling Apoptotic Process Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Cell Death Programmed Necrotic Cell Death Programmed Cell Death Necrotic Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Death Death Negative Regulation Of DNA Binding Regulation Of Catalytic Activity Establishment Of Protein Localization To Organelle Positive Regulation Of Cellular Protein Metabolic Process	Protein Deneddylation Cullin Deneddylation Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Monoubiquitination Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Modification Process G1/S Transition Of Mitotic Cell Cycle Proteolysis Viral Process Cellular Macromolecule Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Arrest Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Catabolic Process Mitotic Cell Cycle Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Mitotic Cell Cycle Notch Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Circadian Rhythm Cell Cycle Process Negative Regulation Of Cell Proliferation Regulation Of Cell Proliferation Regulation Of DNA-templated Transcription In Response To Stress Response To Abiotic Stimulus Cell Communication Metabolic Process Negative Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Signal Transduction Histone H2A Monoubiquitination Cell Cycle Histone H2A Ubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Signaling
Tagcloud ?		acetylated acetylation acetyltransferases alters catalyzes creb deacetylation dramatically enzyme expressing forms functionally hek293 inositol internal limiting lysine lysines mammalian modification phosphorylated posttranslational silent sits spectrometry stability stably trisphosphate unacetylated	abnormal assigned calculated cop count css escc esophageal esophagectomy follows glasgow gps0 gps2 hypoalbuminemia indexes kaplan log lymphocyte meier neutrophil nlr nlr0 nlr1 nlr2 platelet predicts prognostic rank
Tagcloud (Difference) ?		acetylated acetylation acetyltransferases alters catalyzes creb deacetylation dramatically enzyme expressing forms functionally hek293 inositol internal limiting lysine lysines mammalian modification phosphorylated posttranslational silent sits spectrometry stability stably trisphosphate unacetylated	abnormal assigned calculated cop count css escc esophageal esophagectomy follows glasgow gps0 gps2 hypoalbuminemia indexes kaplan log lymphocyte meier neutrophil nlr nlr0 nlr1 nlr2 platelet predicts prognostic rank
Tagcloud (Intersection) ?