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TUBA1B and NFKBIA
Number of citations of the paper that reports this interaction (PubMedID
9372968
)
69
Data Source:
HPRD
(in vivo)
TUBA1B
NFKBIA
Description
tubulin alpha 1b
NFKB inhibitor alpha
Image
GO Annotations
Cellular Component
Cytoplasm
Cytoskeleton
Microtubule
Cytoplasmic Microtubule
Cilium
Microtubule Cytoskeleton
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
I-kappaB/NF-kappaB Complex
Molecular Function
Nucleotide Binding
Double-stranded RNA Binding
GTPase Activity
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Protein Binding
Nuclear Localization Sequence Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
NF-kappaB Binding
Protein Sequestering Activity
Transcription Regulator Inhibitor Activity
Biological Process
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Microtubule-based Process
Cytoskeleton-dependent Intracellular Transport
Cell Division
Cellular Response To Interleukin-4
Negative Regulation Of Transcription By RNA Polymerase II
Immune System Process
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Inflammatory Response
Notch Signaling Pathway
Canonical NF-kappaB Signal Transduction
Regulation Of Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Signal Transduction Involved In Regulation Of Gene Expression
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Cholesterol Transport
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Regulation Of Cell Population Proliferation
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Exogenous DsRNA
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
B Cell Receptor Signaling Pathway
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Cellular Response To Cold
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Recruitment of NuMA to mitotic centrosomes
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Recycling pathway of L1
Hedgehog 'off' state
Cargo trafficking to the periciliary membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
Carboxyterminal post-translational modifications of tubulin
Carboxyterminal post-translational modifications of tubulin
RHOH GTPase cycle
HCMV Early Events
Assembly and cell surface presentation of NMDA receptors
Activation of AMPK downstream of NMDARs
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins
PKR-mediated signaling
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
SARS-CoV-1 activates/modulates innate immune responses
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Epothilone D
Patupilone
CYT997
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Acetylsalicylic acid
Bardoxolone methyl
Astaxanthin
Diseases
Hodgkin lymphoma
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
GWAS
Ambidextrousness (
32989287
)
Bipolar disorder (
31043756
)
Brain morphology (MOSTest) (
32665545
)
Left-handedness (
32989287
)
Left–right brain asymmetry (
33723403
)
Appendicular lean mass (
33097823
)
Asthma (
32296059
30929738
)
Asthma (childhood onset) (
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Creatine kinase levels (
29403010
)
Eczema (
31361310
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory skin disease (
25574825
)
Lymphocyte count (
32888494
27863252
)
PR interval (
32439900
)
Psoriasis (
20953190
25903422
25854761
25574825
23143594
20953189
)
Psoriasis vulgaris (
26626624
)
Pulse pressure (
30578418
27841878
)
Rheumatoid arthritis (
32723749
)
Systolic blood pressure (
28739976
27841878
30578418
)
White blood cell count (
32888494
)
Interacting Genes
39 interacting genes:
A2M
AGTRAP
EML4
EPN2
ESR1
FOXP1
FYN
GRM7
GZMM
HDAC6
ISG15
LINC00624
MAPT
MINK1
MTCL1
MYC
NFKBIA
OGT
PFDN5
PIK3R1
PSEN1
PTEN
PTP4A1
PTPRF
PXN
RNF26
RSPH1
RUNX1
SIAH1
SLX1B
SMAD2
SNAP91
SRPK2
SUMO2
TERT
TMEM253
TOM1L1
TUBG1
WEE2-AS1
92 interacting genes:
ABL1
ARRB1
ARRB2
ATF4
AURKA
BARD1
BTRC
CAPN1
CAPN2
CD7
CDC34
CHUK
COMMD1
COPS8
CSNK2A1
CUL1
DNAJA3
DYNLL1
EIF2AK2
ELP1
ENKD1
FBXW11
G3BP2
HDAC1
HDAC3
HNRNPA1
HOXA9
HOXB7
HSPB1
IKBKB
IKBKE
IKBKG
IKZF4
ITPK1
JAK2
LCK
LYL1
MAP3K1
MAP3K14
MAP3K2
MAP3K3
MAP3K7
MCM5
MCM7
MED19
NCOR2
NEDD9
NFKB1
NFKB2
NFKBIB
NKIRAS1
NKIRAS2
PIK3R1
PIR
POLR2C
POM121
PRKCA
PRKCI
PSMA2
PSMD3
PTPN1
PTPN13
REL
RELA
RNF115
RPS6KA1
RPS6KA3
RWDD3
SKP1
SLC25A4
SLC25A5
SRC
ST7
SUMO1
SUMO4
TBK1
TCL1A
TNF
TNFSF11
TP53
TUBA1B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2L3
UBE2M
UBE2S
USP39
VCP
ZNF212
Entrez ID
10376
4792
HPRD ID
03960
01235
Ensembl ID
ENSG00000123416
ENSG00000100906
Uniprot IDs
P68363
P25963
PDB IDs
2E4H
5IJ0
5IJ9
5N5N
6E7B
6E7C
6I2I
6J4V
6J8O
6QUS
6QUY
6QVE
6QVJ
6S8L
7LXB
7M18
7M20
7PJF
7SJ7
7SJ8
7SJ9
7SJA
7Z6S
7ZCW
8T42
8U3Z
8V2J
8VA2
8VRJ
8VRK
8VT7
9BP6
1IKN
1NFI
6TTU
6Y1J
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Developmental Process
Beta-catenin Binding
Neuron Projection Organization
Negative Regulation Of Cellular Component Organization
Regulation Of Myeloid Cell Differentiation
Regulation Of Cellular Component Organization
Regulation Of Multicellular Organismal Development
Negative Regulation Of Multicellular Organismal Process
Regulation Of Developmental Process
Regulation Of Signal Transduction
Regulation Of Cell Development
Regulation Of Cell Communication
Regulation Of Signaling
Response To Stress
Regulation Of Anatomical Structure Morphogenesis
Negative Regulation Of Cell Differentiation
Regulation Of Protein Localization To Nucleus
Enzyme Binding
Negative Regulation Of Cell Development
Positive Regulation Of Protein Oligomerization
Negative Regulation Of Signal Transduction
Negative Regulation Of Protein Metabolic Process
Growth Factor Receptor Binding
Dendritic Spine Organization
Ubiquitin Protein Ligase Binding
Negative Regulation Of Myeloid Cell Differentiation
Organelle Organization
Clathrin Binding
Negative Regulation Of Hydrogen Peroxide Metabolic Process
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Neuron Projection Development
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Neuron Projection
Regulation Of Cell Differentiation
Cellular Response To Reactive Oxygen Species
Cellular Response To Stress
Alpha-tubulin Binding
Tau Protein Binding
Postsynapse Organization
Positive Regulation Of Signal Transduction
Positive Regulation Of Cellular Component Organization
Regulation Of Protein Localization
Negative Regulation Of Gene Expression
Protein Modification Process
Regulation Of Establishment Of Protein Localization
Inclusion Body Assembly
Regulation Of Myeloid Leukocyte Differentiation
Regulation Of Canonical NF-kappaB Signal Transduction
Nucleoplasm
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Protein Modification Process
Cytosol
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signal Transduction
Regulation Of Metabolic Process
Canonical NF-kappaB Signal Transduction
Macromolecule Metabolic Process
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
ATP Binding
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Modification-dependent Protein Catabolic Process
Protein Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Signal Transduction
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Negative Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Intracellular Signaling Cassette
Negative Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Protein Modification By Small Protein Conjugation
Protein Kinase Activity
Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Macromolecule Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
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