TUBA1B and GZMM

Number of citations of the paper that reports this interaction (PubMedID 18523284)
0

Data Source:
BioGRID (enzymatic study)

		TUBA1B	GZMM
Description		tubulin alpha 1b	granzyme M
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton	Extracellular Region Extracellular Space Membrane
	Molecular Function	Nucleotide Binding Double-stranded RNA Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Ubiquitin Protein Ligase Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cell Division Cellular Response To Interleukin-4	T Cell Mediated Cytotoxicity Immune System Process Proteolysis Apoptotic Process Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin RHOH GTPase cycle HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Alternative complement activation
Drugs		Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS		Ambidextrousness ( 32989287) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403)
Interacting Genes		39 interacting genes: A2M AGTRAP EML4 EPN2 ESR1 FOXP1 FYN GRM7 GZMM HDAC6 ISG15 LINC00624 MAPT MINK1 MTCL1 MYC NFKBIA OGT PFDN5 PIK3R1 PSEN1 PTEN PTP4A1 PTPRF PXN RNF26 RSPH1 RUNX1 SIAH1 SLX1B SMAD2 SNAP91 SRPK2 SUMO2 TERT TMEM253 TOM1L1 TUBG1 WEE2-AS1	6 interacting genes: DFFA EZR NPM1 PARP1 TUBA1B ZNF774
Entrez ID		10376	3004
HPRD ID		03960	02633
Ensembl ID		ENSG00000123416	ENSG00000197540
Uniprot IDs		P68363	P51124 U3KQV5
PDB IDs		2E4H 5IJ0 5IJ9 5N5N 6E7B 6E7C 6I2I 6J4V 6J8O 6QUS 6QUY 6QVE 6QVJ 6S8L 7LXB 7M18 7M20 7PJF 7SJ7 7SJ8 7SJ9 7SJA 7Z6S 7ZCW 8T42 8U3Z 8V2J 8VA2 8VRJ 8VRK 8VT7 9BP6	2ZGC 2ZGH 2ZGJ 2ZKS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Developmental Process Beta-catenin Binding Neuron Projection Organization Negative Regulation Of Cellular Component Organization Regulation Of Myeloid Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Multicellular Organismal Development Negative Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Signal Transduction Regulation Of Cell Development Regulation Of Cell Communication Regulation Of Signaling Response To Stress Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Cell Differentiation Regulation Of Protein Localization To Nucleus Enzyme Binding Negative Regulation Of Cell Development Positive Regulation Of Protein Oligomerization Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Growth Factor Receptor Binding Dendritic Spine Organization Ubiquitin Protein Ligase Binding Negative Regulation Of Myeloid Cell Differentiation Organelle Organization Clathrin Binding Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Communication Negative Regulation Of Signaling Neuron Projection Development Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Neuron Projection Regulation Of Cell Differentiation Cellular Response To Reactive Oxygen Species Cellular Response To Stress Alpha-tubulin Binding Tau Protein Binding Postsynapse Organization Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Regulation Of Protein Localization Negative Regulation Of Gene Expression Protein Modification Process Regulation Of Establishment Of Protein Localization Inclusion Body Assembly Regulation Of Myeloid Leukocyte Differentiation	Macrophage Differentiation NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Protein-DNA Complex NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Protein-containing Complex NAD+-protein-histidine ADP-ribosyltransferase Activity Positive Regulation Of Protein Localization NAD+-protein-tyrosine ADP-ribosyltransferase Activity Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Cellular Response To UV DNA Metabolic Process DNA ADP-ribosylation Positive Regulation Of Myofibroblast Differentiation Cellular Response To Light Stimulus Regulation Of Base-excision Repair Myeloid Leukocyte Differentiation Response To UV Negative Regulation Of ATP Biosynthetic Process Cellular Response To Radiation NAD+-protein-serine ADP-ribosyltransferase Activity ATP Generation From Poly-ADP-D-ribose Negative Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization To Nucleus NAD DNA ADP-ribosyltransferase Activity Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Deoxyribonuclease Activity Negative Regulation Of Apoptotic DNA Fragmentation Deoxyribonuclease Inhibitor Activity Negative Regulation Of Nuclease Activity Negative Regulation Of Catalytic Activity Regulation Of Endoribonuclease Activity Intestinal Hexose Absorption Terminal Web Assembly Protein Localization To Cell Cortex Intestinal D-glucose Absorption Transcription Pausing By RNA Polymerase II Replication Fork Reversal Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity Positive Regulation Of Centrosome Duplication Membrane To Membrane Docking Regulation Of Microvillus Length Microtubule-based Process Positive Regulation Of Protein Localization To Nucleolus Ribosomal Large Subunit Export From Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process
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