TUBA1B and FOXP1

Number of citations of the paper that reports this interaction (PubMedID 31623628)
49

Data Source:
BioGRID (unspecified method)

		TUBA1B	FOXP1
Description		tubulin alpha 1b	forkhead box P1
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton	Chromatin Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Double-stranded RNA Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Ubiquitin Protein Ligase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Androgen Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cell Division Cellular Response To Interleukin-4	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Apoptotic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Striatum Development Osteoclast Differentiation Forebrain Development Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-12 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-21 Production Response To Testosterone Osteoclast Development Macrophage Activation Monocyte Activation Endothelial Cell Activation Regulation Of Monocyte Differentiation Negative Regulation Of DNA-templated Transcription Animal Organ Development Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development T Follicular Helper Cell Differentiation Cellular Response To Tumor Necrosis Factor Regulation Of Defense Response To Bacterium Regulation Of Macrophage Colony-stimulating Factor Production Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Regulation Of Endothelial Tube Morphogenesis Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin RHOH GTPase cycle HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS		Ambidextrousness ( 32989287) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403)	Adult body size ( 32376654) Adventurousness ( 30643258) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 31308545) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 32296059) Attention deficit hyperactivity disorder ( 18821565) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Barrett's esophagus ( 24121790) Barrett's esophagus or Esophageal adenocarcinoma ( 31527586 27527254) Basal cell carcinoma ( 31174203 33549134 27539887) Beef consumption ( 32066663) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Childhood maltreatment ( 32066696) Chronotype ( 30696823) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Cutaneous squamous cell carcinoma ( 32041948) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) Esophageal adenocarcinoma ( 24121790) Familial lung adenocarcinoma ( 29924316) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Haemorrhoidal disease ( 33888516) Hand grip strength ( 29691431) Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29617998 24002674 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244 24076602) Nasal polyps ( 30643255) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Non-melanoma skin cancer ( 29739929) Nose size ( 27182965) Number of sexual partners ( 30643258) Oily fish consumption ( 32066663) Optic disc size ( 31809533) Pork consumption ( 32066663) PR interval ( 32439900) Primary sclerosing cholangitis ( 27992413) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 30285260) Selective IgA deficiency ( 27723758) Smoking initiation ( 33082346) Squamous cell carcinoma ( 26829030) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Subcutaneous adipose tissue ( 22589738) Systolic blood pressure ( 27841878) Tooth agenesis (maxillary lateral incisors) ( 29364747) Vitiligo ( 27723757) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006) White blood cell count ( 32888494)
Interacting Genes		39 interacting genes: A2M AGTRAP EML4 EPN2 ESR1 FOXP1 FYN GRM7 GZMM HDAC6 ISG15 LINC00624 MAPT MINK1 MTCL1 MYC NFKBIA OGT PFDN5 PIK3R1 PSEN1 PTEN PTP4A1 PTPRF PXN RNF26 RSPH1 RUNX1 SIAH1 SLX1B SMAD2 SNAP91 SRPK2 SUMO2 TERT TMEM253 TOM1L1 TUBG1 WEE2-AS1	117 interacting genes: AKR1A1 ALB ALYREF ANLN ANXA2 AURKA BAZ2B C1QBP CCDC167 CCDC73 CDKN2AIP CHSY1 CPSF6 CSDE1 CTBP1 DCD DDX17 DDX19B DLAT DMD DOC2A ECE2 EXOG FOXP2 FOXP4 GAPDH GAR1 GOLGA2 H1-4 H2AC25 HERC1 HNRNPD HNRNPH1 HNRNPK HNRNPUL1 HSPA8 HSPB1 HYDIN IGF2BP3 IKZF1 IL3RA IQSEC2 KIF27 LRRK1 MNAT1 MTUS1 MYH7B NCOR2 NLRC4 NR2F1 NR2F2 PARN PCBP2 PCSK4 PKD1P6 POP7 PTBP1 PURA RAG2 RAN RBMS2 RBMX RGL1 RPL22 RPL23A RPL27 RPL28 RPL31 RPL35 RPL37A RPL4 RPL5 RPL6 RPS15A RPS16 RPS20 RPS27A RPS3 RUVBL1 SATB1 SATB2 SLC22A16 SMARCA2 SNRPA1 SNRPB2 SNRPC SNRPD1 SNRPD2 SNRPE SNRPF SNRPN SOX5 SRP14 SRSF1 SRSF3 SRSF8 SSBP1 STAU1 STAU2 STRAP TARBP2 TBC1D23 THUMPD1 TNFRSF1B TRA2A TUBA1B TUBA8 TYW1B UGGT1 UMPS WBP11 WDR11 WDR72 YY1 ZC3HAV1 ZDHHC16 ZMYM2
Entrez ID		10376	27086
HPRD ID		03960	18518
Ensembl ID		ENSG00000123416	ENSG00000114861
Uniprot IDs		P68363	A0A0B4J2F3 A0A3B3IRW5 A0A3B3IST0 A0A3B3IT66 Q548T7 Q8N2P0 Q8TEA2 Q9H334
PDB IDs		2E4H 5IJ0 5IJ9 5N5N 6E7B 6E7C 6I2I 6J4V 6J8O 6QUS 6QUY 6QVE 6QVJ 6S8L 7LXB 7M18 7M20 7PJF 7SJ7 7SJ8 7SJ9 7SJA 7Z6S 7ZCW 8T42 8U3Z 8V2J 8VA2 8VRJ 8VRK 8VT7 9BP6	2KIU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Developmental Process Beta-catenin Binding Neuron Projection Organization Negative Regulation Of Cellular Component Organization Regulation Of Myeloid Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Multicellular Organismal Development Negative Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Signal Transduction Regulation Of Cell Development Regulation Of Cell Communication Regulation Of Signaling Response To Stress Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Cell Differentiation Regulation Of Protein Localization To Nucleus Enzyme Binding Negative Regulation Of Cell Development Positive Regulation Of Protein Oligomerization Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Growth Factor Receptor Binding Dendritic Spine Organization Ubiquitin Protein Ligase Binding Negative Regulation Of Myeloid Cell Differentiation Organelle Organization Clathrin Binding Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Communication Negative Regulation Of Signaling Neuron Projection Development Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Neuron Projection Regulation Of Cell Differentiation Cellular Response To Reactive Oxygen Species Cellular Response To Stress Alpha-tubulin Binding Tau Protein Binding Postsynapse Organization Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Regulation Of Protein Localization Negative Regulation Of Gene Expression Protein Modification Process Regulation Of Establishment Of Protein Localization Inclusion Body Assembly Regulation Of Myeloid Leukocyte Differentiation	RNA Binding Ribonucleoprotein Complex RNA Processing Cytosolic Ribosome RNA Splicing MRNA Metabolic Process MRNA Binding Nucleic Acid Metabolic Process MRNA Processing Cytoplasmic Translation RNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Structural Constituent Of Ribosome Catalytic Step 2 Spliceosome Nucleus Spliceosomal Complex Ribosome Cytosolic Large Ribosomal Subunit U1 SnRNP Nucleic Acid Binding U2 SnRNP Small Nuclear Ribonucleoprotein Complex Translation U4 SnRNP Protein-RNA Complex Assembly U2-type Prespliceosome Assembly Nucleoplasm PICln-Sm Protein Complex U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Regulation Of MRNA Splicing, Via Spliceosome SMN-Sm Protein Complex 7-methylguanosine Cap Hypermethylation U5 SnRNP Macromolecule Biosynthetic Process Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Spliceosomal SnRNP Assembly Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Assembly Methylosome U2-type Precatalytic Spliceosome Nucleolus Extracellular Exosome Cytosolic Small Ribosomal Subunit Focal Adhesion
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