ETV6 and HDAC9

Number of citations of the paper that reports this interaction (PMID 12590135)
21

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		ETV6	HDAC9
Gene Name		ets variant 6	histone deacetylase 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Histone Methyltransferase Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding	Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Inflammatory Response Notch Signaling Pathway Heart Development Histone Deacetylation B Cell Differentiation Cellular Response To Insulin Stimulus Peptidyl-lysine Deacetylation B Cell Activation Negative Regulation Of Transcription, DNA-templated Regulation Of Skeletal Muscle Fiber Development Regulation Of Striated Muscle Cell Differentiation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs			Valproic Acid
Diseases
GWAS		Height ( 20881960 23563607 18391951)	Male-pattern baldness ( 22693459) Obesity-related traits ( 23251661) Retinopathy in non-diabetics ( 23393555) Stroke ( 22306652) Stroke (ischemic) ( 23041239) Ulcerative colitis ( 20848476)
Protein-Protein Interactions		15 interactors: AP1M1 CRKL FBXL6 FLI1 GAB2 GRB2 HDAC9 KAT5 L3MBTL1 PIN1 SIN3A SMURF1 SUMO1 UBE2I WDYHV1	31 interactors: ANKRA2 BCL6 CBX5 CTBP1 ESR1 ETV6 HDAC1 HDAC3 HDAC4 HIST2H3A HIST4H4 JUN MAML1 MAPK10 MAPK8 MAPK9 MEF2A MEF2C NCOR1 NRIP1 PKD1 SIN3A SIN3B SUMO1 SUMO2 SUV39H1 SYK TRIM29 USF1 YWHAZ ZBTB16
Entrez ID		2120	9734
HPRD ID		15976	05944
Ensembl ID		ENSG00000139083	ENSG00000048052
Uniprot IDs		P41212	B7Z3P7 Q9UKV0
PDB IDs		1JI7 1LKY 2DAO 2QAR 2QB0 2QB1
Enriched GO Terms of Interacting Partners?		Immune System Process Immune System Development Cellular Response To Organic Substance Peptidyl-lysine Modification Hemopoiesis Negative Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of Immune System Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Protein Sumoylation Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Viral Process Cellular Protein Metabolic Process Developmental Process Negative Regulation Of DNA Binding Positive Regulation Of Metabolic Process Chromatin Modification Response To Stress Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Response To Methylglyoxal Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Histone H3-K27 Acetylation Regulation Of Signal Transduction Histone Deacetylation Chromatin Organization Protein Deacetylation Anatomical Structure Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Defense Response Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Receptor Metabolic Process Regulation Of Defense Response To Virus Innate Immune Response Regulation Of DNA Binding Regulation Of Signaling Signal Transduction In Response To DNA Damage Cell Surface Receptor Signaling Pathway Organelle Organization	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Stress-activated MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor 2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Activation Of Innate Immune Response RNA Metabolic Process Regulation Of Histone Deacetylation Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Binding Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stress
Tagcloud ?		10q11 12p 12p13 14q11 15q15 1p13 1q31 abn add amli balanced bip biphenotypic breakpoints cmml cytogenetically del deleted heterozygosity intron lymphoblastic myelodysplasia myelomonocytic primers rearrangement rearrangements sixth southern translocations	ascl2 c4b dab2ip dlk1 eya4 fabp3 fzd9 gas7 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1
Tagcloud (Difference) ?		10q11 12p 12p13 14q11 15q15 1p13 1q31 abn add amli balanced bip biphenotypic breakpoints cmml cytogenetically del deleted heterozygosity intron lymphoblastic myelodysplasia myelomonocytic primers rearrangement rearrangements sixth southern translocations	ascl2 c4b dab2ip dlk1 eya4 fabp3 fzd9 gas7 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1
Tagcloud (Intersection) ?