ETV6 and L3MBTL1

Number of citations of the paper that reports this interaction (PMID 12588862)
30

Data Source:
HPRD (in vitro, in vivo)

		ETV6	L3MBTL1
Gene Name		ets variant 6	l(3)mbt-like 1 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Plasma Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Nucleosome Binding Nucleosomal Histone Binding SAM Domain Binding Methylated Histone Binding Histone Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Chromatin Modification Hemopoiesis Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle
Pathways
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391951)
Protein-Protein Interactions		15 interactors: AP1M1 CRKL FBXL6 FLI1 GAB2 GRB2 HDAC9 KAT5 L3MBTL1 PIN1 SIN3A SMURF1 SUMO1 UBE2I WDYHV1	7 interactors: CBX3 ETV6 ETV7 HIST1H1B HIST4H4 RB1 SETD7
Entrez ID		2120	26013
HPRD ID		15976	16387
Ensembl ID		ENSG00000139083	ENSG00000185513
Uniprot IDs		P41212	Q9Y468
PDB IDs		1JI7 1LKY 2DAO 2QAR 2QB0 2QB1	1OYX 1OZ2 1OZ3 2PQW 2RHI 2RHU 2RHX 2RHY 2RHZ 2RI2 2RI3 2RI5 2RJC 2RJD 2RJE 2RJF 3OQ5 3P8H 3UWN
Enriched GO Terms of Interacting Partners?		Immune System Process Immune System Development Cellular Response To Organic Substance Peptidyl-lysine Modification Hemopoiesis Negative Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of Immune System Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Protein Sumoylation Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Viral Process Cellular Protein Metabolic Process Developmental Process Negative Regulation Of DNA Binding Positive Regulation Of Metabolic Process Chromatin Modification Response To Stress Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Response To Methylglyoxal Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Histone H3-K27 Acetylation Regulation Of Signal Transduction Histone Deacetylation Chromatin Organization Protein Deacetylation Anatomical Structure Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Defense Response Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Receptor Metabolic Process Regulation Of Defense Response To Virus Innate Immune Response Regulation Of DNA Binding Regulation Of Signaling Signal Transduction In Response To DNA Damage Cell Surface Receptor Signaling Pathway Organelle Organization	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromatin Organization Chromosome Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Modification Chromatin Remodeling Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Localization To Chromosome Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleosome Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Chromatin Assembly Organelle Organization Nucleosome Organization RNA Metabolic Process Chromatin Assembly Or Disassembly Regulation Of Centromere Complex Assembly Histone H4-K20 Demethylation Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Protein-DNA Complex Assembly Regulation Of Transcription From RNA Polymerase II Promoter Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Regulation Of Myeloid Cell Differentiation DNA Packaging Cellular Macromolecule Biosynthetic Process Negative Regulation Of Megakaryocyte Differentiation Attachment Of Mitotic Spindle Microtubules To Kinetochore Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Establishment Of Protein Localization To Chromatin
Tagcloud ?		10q11 12p 12p13 14q11 15q15 1p13 1q31 abn add amli balanced bip biphenotypic breakpoints cmml cytogenetically del deleted heterozygosity intron lymphoblastic myelodysplasia myelomonocytic primers rearrangement rearrangements sixth southern translocations	advances alterations asxl1 discovery driving epigenetic existence idh1 idh2 jak leukemic modifiers modify modifying mpn mpns myeloproliferative neoplasms nevertheless predate predominant prmt5 reading reviews stat suspected technologies tet2 translational
Tagcloud (Difference) ?		10q11 12p 12p13 14q11 15q15 1p13 1q31 abn add amli balanced bip biphenotypic breakpoints cmml cytogenetically del deleted heterozygosity intron lymphoblastic myelodysplasia myelomonocytic primers rearrangement rearrangements sixth southern translocations	advances alterations asxl1 discovery driving epigenetic existence idh1 idh2 jak leukemic modifiers modify modifying mpn mpns myeloproliferative neoplasms nevertheless predate predominant prmt5 reading reviews stat suspected technologies tet2 translational
Tagcloud (Intersection) ?