ETV6 and L3MBTL1

Number of citations of the paper that reports this interaction (PubMedID 12588862)
0

Data Source:
HPRD (in vitro, in vivo)

		ETV6	L3MBTL1
Description		ETS variant transcription factor 6	L3MBTL histone methyl-lysine binding protein 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleolus Cytosol Plasma Membrane	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Chromatin Lock Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding	Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding SAM Domain Binding Histone Binding Identical Protein Binding Metal Ion Binding Histone H4K20me2 Reader Activity Histone H1 Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Vitellogenesis Neurogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Proliferation Mesenchymal Cell Apoptotic Process	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Mitotic Nuclear Division Hemopoiesis Heterochromatin Formation Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Constitutive Heterochromatin Formation
Pathways		Signaling by membrane-tethered fusions of PDGFRA or PDGFRB Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	Regulation of TP53 Activity through Methylation
Drugs			2-(N-morpholino)ethanesulfonic acid
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Alanine aminotransferase levels ( 33547301) Appendicular lean mass ( 33097823) Asthma ( 27611488) Body size at age 10 ( 32376654) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Colorectal cancer ( 27145994) Height ( 20881960 23563607 25282103 18391951 28552196 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nicotine dependence symptom count ( 25555482) Night sleep phenotypes ( 27126917) Phosphorus levels ( 29403010) Red blood cell count ( 32888494) Triglyceride levels ( 32203549)	Antibody level in response to infection ( 25758998) Daytime sleep phenotypes ( 27126917)
Interacting Genes		18 interacting genes: AP1M1 AXIN1 CEBPA CRKL FBXL6 FLI1 GAB2 GRB2 HDAC9 KAT5 L3MBTL1 NFE2L2 NTAQ1 SIN3A SMURF1 SUMO1 TRAF2 UBE2I	8 interacting genes: CBX3 ETV6 ETV7 FXR2 H1-5 H4C16 RB1 SETD7
Entrez ID		2120	26013
HPRD ID		15976	16387
Ensembl ID		ENSG00000139083	ENSG00000185513
Uniprot IDs		A0A0S2Z3C9 A0A0S2Z3N6 P41212	A0A0A0MRR4 A0A3B3ISS0 A0A3F2YNZ1 B0QYN5 Q9Y468
PDB IDs		1JI7 1LKY 2DAO 2QAR 2QB0 2QB1 5L0P 7JU2 7N1O 7N2B 7T8J 7TDY 7TW7 7TW8 7TW9 7U4W 7U4Z 8BWU 8E1F 8FRJ 8FRK 8FT6 8FT8 8FZ3 8FZU 8FZV 8THA 9DAM 9DB5 9DOC 9DP8 9DVG 9FEH	1OYX 1OZ2 1OZ3 2PQW 2RHI 2RHU 2RHX 2RHY 2RHZ 2RI2 2RI3 2RI5 2RJC 2RJD 2RJE 2RJF 3OQ5 3P8H 3UWN 6BYB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Proteolysis Regulation Of Immune System Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Immune System Process CD27 Signaling Pathway Small Protein Activating Enzyme Binding Negative Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Protein Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cell Development Cellular Response To Xenobiotic Stimulus Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Proteolysis Negative Regulation Of RNA Biosynthetic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Enzyme Binding Chromatin Remodeling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Signaling Adaptor Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Targeting To Vacuole Involved In Autophagy Protein Domain Specific Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Macromolecule Catabolic Process Regulation Of Hematopoietic Stem Cell Differentiation I-SMAD Binding Transcription Regulator Complex Regulation Of RNA Metabolic Process Chromatin Cellular Developmental Process Chromatin Binding Proteasomal Protein Catabolic Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Transcription Factor Binding	Chromatin Lock Complex Chromatin Remodeling Chromatin Organization Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Heterochromatin Protein Localization To Chromosome, Centromeric Region Negative Regulation Of RNA Metabolic Process Euchromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Thermosensory Behavior Negative Regulation Of Macromolecule Metabolic Process Chromosome Organization RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Structural Constituent Of Chromatin Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Vitellogenesis Regulation Of RNA Biosynthetic Process Nucleosome Nucleosome Assembly Nucleosome Organization Protein Localization To Chromosome Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Positive Regulation Of Collagen Fibril Organization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Senescence-associated Heterochromatin Focus DNA Binding Nucleus Heterochromatin Formation Regulation Of Gene Expression Glial Cell Apoptotic Process Rb-E2F Complex Peptidyl-lysine Dimethylation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Centromere Complex Assembly Potassium:chloride Symporter Activity Enucleate Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic
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