ETV6 and FLI1

Number of citations of the paper that reports this interaction (PMID 9651344)
19

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		ETV6	FLI1
Gene Name		ets variant 6	Fli-1 proto-oncogene, ETS transcription factor
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm	Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Hemostasis Blood Circulation Organ Morphogenesis Cell Differentiation Megakaryocyte Development Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391951)	Height ( 20881960) Myopia (pathological) ( 23049088) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		15 interactors: AP1M1 CRKL FBXL6 FLI1 GAB2 GRB2 HDAC9 KAT5 L3MBTL1 PIN1 SIN3A SMURF1 SUMO1 UBE2I WDYHV1	19 interactors: BRCA1 CTBP2 ELK1 ERG ETV6 EWSR1 GATA1 KLF1 PIAS1 PIAS2 PRKCD SIAH1 SMAD3 SMAD9 SOX30 SRF SUMO1 TDP2 UBE2I
Entrez ID		2120	2313
HPRD ID		15976	01901
Ensembl ID		ENSG00000139083	ENSG00000151702
Uniprot IDs		P41212	Q01543
PDB IDs		1JI7 1LKY 2DAO 2QAR 2QB0 2QB1	1FLI 1X66 2YTU
Enriched GO Terms of Interacting Partners?		Immune System Process Immune System Development Cellular Response To Organic Substance Peptidyl-lysine Modification Hemopoiesis Negative Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of Immune System Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Protein Sumoylation Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Viral Process Cellular Protein Metabolic Process Developmental Process Negative Regulation Of DNA Binding Positive Regulation Of Metabolic Process Chromatin Modification Response To Stress Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Response To Methylglyoxal Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Histone H3-K27 Acetylation Regulation Of Signal Transduction Histone Deacetylation Chromatin Organization Protein Deacetylation Anatomical Structure Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Defense Response Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Receptor Metabolic Process Regulation Of Defense Response To Virus Innate Immune Response Regulation Of DNA Binding Regulation Of Signaling Signal Transduction In Response To DNA Damage Cell Surface Receptor Signaling Pathway Organelle Organization	Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Sumoylation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Binding Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Androgen Receptor Signaling Pathway Regulation Of Signaling Erythrocyte Development Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Intracellular Steroid Hormone Receptor Signaling Pathway Developmental Process Metabolic Process Peptidyl-lysine Modification Peptidyl-amino Acid Modification
Tagcloud ?		10q11 12p 12p13 14q11 15q15 1p13 1q31 abn add amli balanced bip biphenotypic breakpoints cmml cytogenetically del deleted heterozygosity intron lymphoblastic myelodysplasia myelomonocytic primers rearrangement rearrangements sixth southern translocations	antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Difference) ?		10q11 12p 12p13 14q11 15q15 1p13 1q31 abn add amli balanced bip biphenotypic breakpoints cmml cytogenetically del deleted heterozygosity intron lymphoblastic myelodysplasia myelomonocytic primers rearrangement rearrangements sixth southern translocations	antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Intersection) ?