ETV6 and FBXL6

Number of citations of the paper that reports this interaction (PMID 18426905)
3

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		ETV6	FBXL6
Gene Name		ets variant 6	F-box and leucine-rich repeat protein 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding	Ubiquitin-protein Transferase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter	Proteolysis Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391951)
Protein-Protein Interactions		15 interactors: AP1M1 CRKL FBXL6 FLI1 GAB2 GRB2 HDAC9 KAT5 L3MBTL1 PIN1 SIN3A SMURF1 SUMO1 UBE2I WDYHV1	3 interactors: ETV6 SKP1 TSC2
Entrez ID		2120	26233
HPRD ID		15976	16429
Ensembl ID		ENSG00000139083	ENSG00000182325
Uniprot IDs		P41212	Q8N531
PDB IDs		1JI7 1LKY 2DAO 2QAR 2QB0 2QB1
Enriched GO Terms of Interacting Partners?		Immune System Process Immune System Development Cellular Response To Organic Substance Peptidyl-lysine Modification Hemopoiesis Negative Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of Immune System Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Protein Sumoylation Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Viral Process Cellular Protein Metabolic Process Developmental Process Negative Regulation Of DNA Binding Positive Regulation Of Metabolic Process Chromatin Modification Response To Stress Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Response To Methylglyoxal Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Histone H3-K27 Acetylation Regulation Of Signal Transduction Histone Deacetylation Chromatin Organization Protein Deacetylation Anatomical Structure Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Defense Response Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Receptor Metabolic Process Regulation Of Defense Response To Virus Innate Immune Response Regulation Of DNA Binding Regulation Of Signaling Signal Transduction In Response To DNA Damage Cell Surface Receptor Signaling Pathway Organelle Organization
Tagcloud ?		10q11 12p 12p13 14q11 15q15 1p13 1q31 abn add amli balanced bip biphenotypic breakpoints cmml cytogenetically del deleted heterozygosity intron lymphoblastic myelodysplasia myelomonocytic primers rearrangement rearrangements sixth southern translocations
Tagcloud (Difference) ?		10q11 12p 12p13 14q11 15q15 1p13 1q31 abn add amli balanced bip biphenotypic breakpoints cmml cytogenetically del deleted heterozygosity intron lymphoblastic myelodysplasia myelomonocytic primers rearrangement rearrangements sixth southern translocations
Tagcloud (Intersection) ?