ETV6 and GAB2

Number of citations of the paper that reports this interaction (PubMedID 15143164)
63

Data Source:
HPRD (in vitro, in vivo)

		ETV6	GAB2
Description		ETS variant transcription factor 6	GRB2 associated binding protein 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleolus Cytosol Plasma Membrane	Cytoplasm Cytosol Plasma Membrane Membrane Membrane Raft
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Vitellogenesis Neurogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Proliferation Mesenchymal Cell Apoptotic Process	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Osteoclast Differentiation Positive Regulation Of Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Signaling by membrane-tethered fusions of PDGFRA or PDGFRB Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	PI3K Cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Constitutive Signaling by Aberrant PI3K in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Interleukin-15 signaling Interleukin receptor SHC signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Alanine aminotransferase levels ( 33547301) Appendicular lean mass ( 33097823) Asthma ( 27611488) Body size at age 10 ( 32376654) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Colorectal cancer ( 27145994) Height ( 20881960 23563607 25282103 18391951 28552196 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nicotine dependence symptom count ( 25555482) Night sleep phenotypes ( 27126917) Phosphorus levels ( 29403010) Red blood cell count ( 32888494) Triglyceride levels ( 32203549)	Alanine aminotransferase levels ( 33547301) Alzheimer's disease (late onset) ( 17553421) Alzheimer's disease (survival time) ( 25649651) Aspartate aminotransferase levels ( 33547301) Blond vs. brown/black hair color ( 30531825) Body mass index ( 28892062) Brown vs. black hair color ( 30531825) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Hair color ( 29662168) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29785010) Lactate dehydrogenase levels ( 29403010) LDL cholesterol ( 30275531) Lipid traits (pleiotropy) (HIPO component 2) ( 30289880) Menarche (age at onset) ( 25231870 21102462) Platelet distribution width ( 32888494) Testicular germ cell tumor ( 28604732 28604728 26503584) Total cholesterol levels ( 30275531) Tourette syndrome ( 30818990) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		18 interacting genes: AP1M1 AXIN1 CEBPA CRKL FBXL6 FLI1 GAB2 GRB2 HDAC9 KAT5 L3MBTL1 NFE2L2 NTAQ1 SIN3A SMURF1 SUMO1 TRAF2 UBE2I	30 interacting genes: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 MYO15B NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SNCA SRC SYK TNFRSF11A ZAP70
Entrez ID		2120	9846
HPRD ID		15976	05866
Ensembl ID		ENSG00000139083	ENSG00000033327
Uniprot IDs		A0A0S2Z3C9 A0A0S2Z3N6 P41212	Q9UQC2
PDB IDs		1JI7 1LKY 2DAO 2QAR 2QB0 2QB1 5L0P 7JU2 7N1O 7N2B 7T8J 7TDY 7TW7 7TW8 7TW9 7U4W 7U4Z 8BWU 8E1F 8FRJ 8FRK 8FT6 8FT8 8FZ3 8FZU 8FZV 8THA 9DAM 9DB5 9DOC 9DP8 9DVG 9FEH	2VWF 2W0Z 5EWZ 5EXA 6Y3R 6Y3S 6ZVB 6ZVC 6ZVD 6ZVE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Proteolysis Regulation Of Immune System Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Immune System Process CD27 Signaling Pathway Small Protein Activating Enzyme Binding Negative Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Protein Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cell Development Cellular Response To Xenobiotic Stimulus Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Proteolysis Negative Regulation Of RNA Biosynthetic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Enzyme Binding Chromatin Remodeling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Signaling Adaptor Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Targeting To Vacuole Involved In Autophagy Protein Domain Specific Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Macromolecule Catabolic Process Regulation Of Hematopoietic Stem Cell Differentiation I-SMAD Binding Transcription Regulator Complex Regulation Of RNA Metabolic Process Chromatin Cellular Developmental Process Chromatin Binding Proteasomal Protein Catabolic Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Transcription Factor Binding	Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of MAPK Cascade Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune Response ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signaling Cassette Leukocyte Activation Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Activation T Cell Costimulation Immune System Process Cell-cell Junction Regulation Of T Cell Activation Cell Activation Regulation Of Lymphocyte Activation Regulation Of Defense Response Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lymphocyte Activation Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of T Cell Activation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Negative Regulation Of Immune System Process Regulation Of Multicellular Organismal Process Cytokine-mediated Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?