NFE2 and MAFK

Number of citations of the paper that reports this interaction (PubMedID 8355703)
44

Data Source:
HPRD (in vitro, in vivo)

		NFE2	MAFK
Description		nuclear factor, erythroid 2	MAF bZIP transcription factor K
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm PML Body Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding WW Domain Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Nucleosome Disassembly Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Hemostasis Positive Regulation Of DNA-templated Transcription Integrated Stress Response Signaling	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	Regulation of HMOX1 expression and activity Heme signaling Regulation of BACH1 activity Nuclear events mediated by NFE2L2 NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Chronotype ( 30696823) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 22139419 24026423) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Platelet count ( 27863252 29403010 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823)
Interacting Genes		22 interacting genes: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP SCAND1 SSX5 TXN UBE2I WWP1 YAP1	11 interacting genes: BACH1 BACH2 DNMT3L HIF1A HOXD12 KAT6A MARS1 NFE2 NFE2L1 NFE2L2 NFE2L3
Entrez ID		4778	7975
HPRD ID		09030	02561
Ensembl ID		ENSG00000123405	ENSG00000198517
Uniprot IDs		A8K3E0 Q16621	O60675
PDB IDs		2KZ5
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus Chromatin Post-translational Protein Modification Positive Regulation Of RNA Metabolic Process Cellular Response To Nutrient Levels Response To Radiation Response To UV Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription N-terminal Peptidyl-lysine Acetylation Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Modification-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxidative Stress Cellular Response To Stress DNA-binding Transcription Factor Activity Integrated Stress Response Signaling Rhythmic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Cellular Response To Chemical Stress Positive Regulation Of Macromolecule Biosynthetic Process Response To Nutrient Levels Positive Regulation Of Biosynthetic Process Protein Monoubiquitination	RNA Polymerase II Transcription Regulator Complex Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Integrated Stress Response Signaling Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Copper Ion DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Copper Ion Positive Regulation Of Metabolic Process Cellular Response To Oxidative Stress Negative Regulation Of Macromolecule Metabolic Process Cell Redox Homeostasis Protein Domain Specific Binding Protein-DNA Complex Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Cellular Response To Chemical Stress Regulation Of Nucleus Organization Positive Regulation Of Glutathione Biosynthetic Process Primary Adaptive Immune Response Involving T Cells And B Cells Regulation Of Body Fluid Levels
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?