NFE2 and HMGN1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		NFE2	HMGN1
Description		nuclear factor, erythroid 2	high mobility group nucleosome binding domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm PML Body Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Female Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding WW Domain Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Protein Binding Nucleosomal DNA Binding
	Biological Process	Nucleosome Disassembly Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Hemostasis Positive Regulation Of DNA-templated Transcription Integrated Stress Response Signaling	Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Response To UV-B Response To UV-C Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Development, Heterochronic Post-embryonic Camera-type Eye Morphogenesis Regulation Of Epithelial Cell Proliferation
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Chronotype ( 30696823) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 22139419 24026423) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Platelet count ( 27863252 29403010 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	LDL cholesterol levels ( 32203549) Lipoprotein (a) levels ( 33730874) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		22 interacting genes: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP SCAND1 SSX5 TXN UBE2I WWP1 YAP1	22 interacting genes: CDC42 CEBPA CHEK2 EP300 GSK3A HMGN2 HPF1 IRF2 LIG4 MDM2 NFE2 PARP1 PPP1CC PRKACA PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ
Entrez ID		4778	3150
HPRD ID		09030	01231
Ensembl ID		ENSG00000123405	ENSG00000205581
Uniprot IDs		A8K3E0 Q16621	P05114 Q6NSG7
PDB IDs		2KZ5
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus Chromatin Post-translational Protein Modification Positive Regulation Of RNA Metabolic Process Cellular Response To Nutrient Levels Response To Radiation Response To UV Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription N-terminal Peptidyl-lysine Acetylation Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Modification-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxidative Stress Cellular Response To Stress DNA-binding Transcription Factor Activity Integrated Stress Response Signaling Rhythmic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Cellular Response To Chemical Stress Positive Regulation Of Macromolecule Biosynthetic Process Response To Nutrient Levels Positive Regulation Of Biosynthetic Process Protein Monoubiquitination	TORC1 Signaling Regulation Of Nucleobase-containing Compound Metabolic Process TOR Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Macromolecule Metabolic Process Response To Nutrient Levels Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Steroid Hormone Protein Serine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Protein Domain Specific Binding Cellular Response To Stress Regulation Of DNA-templated Transcription Response To Gamma Radiation Regulation Of RNA Biosynthetic Process Cellular Response To Lithium Ion Regulation Of Gene Expression Protein Serine/threonine Kinase Activity Regulation Of Metabolic Process Response To Lithium Ion Chromatin Organization Histone H3S28 Kinase Activity Response To Hormone Regulation Of Transcription By RNA Polymerase II Protein Kinase Binding Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Radiation Chromosome, Telomeric Region Nucleus Negative Regulation Of Biosynthetic Process Protein Kinase Activity Protein Modification Process Protein Phosphorylation
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