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NFE2 and TXN
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
NFE2
TXN
Description
nuclear factor, erythroid 2
thioredoxin
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
PML Body
Protein-DNA Complex
RNA Polymerase II Transcription Regulator Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Extracellular Exosome
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Identical Protein Binding
Sequence-specific DNA Binding
WW Domain Binding
Sequence-specific Double-stranded DNA Binding
RNA Binding
Thioredoxin-disulfide Reductase (NADPH) Activity
Protein Binding
Protein-disulfide Reductase Activity
Protein Homodimerization Activity
Protein-disulfide Reductase [NAD(P)H] Activity
Biological Process
Nucleosome Disassembly
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Hemostasis
Positive Regulation Of DNA-templated Transcription
Integrated Stress Response Signaling
Negative Regulation Of Transcription By RNA Polymerase II
Response To Radiation
Cellular Homeostasis
Positive Regulation Of DNA Binding
Cell Redox Homeostasis
Negative Regulation Of Protein Export From Nucleus
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Detoxification Of Hydrogen Peroxide
Response To Nitric Oxide
Pathways
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Factors involved in megakaryocyte development and platelet production
Factors involved in megakaryocyte development and platelet production
Oxidative Stress Induced Senescence
Detoxification of Reactive Oxygen Species
Interconversion of nucleotide di- and triphosphates
TP53 Regulates Metabolic Genes
Protein repair
The NLRP3 inflammasome
The NLRP3 inflammasome
Regulation of FOXO transcriptional activity by acetylation
Purinergic signaling in leishmaniasis infection
Purinergic signaling in leishmaniasis infection
NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Chronotype (
30696823
)
High light scatter reticulocyte count (
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean platelet volume (
22139419
24026423
)
Mean spheric corpuscular volume (
32888494
)
Meat-related diet (
32066663
)
Platelet count (
27863252
29403010
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
)
Red cell distribution width (
28957414
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Mean corpuscular hemoglobin (
32888494
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
22 interacting genes:
ATF4
BTRC
CREBBP
ELF5
HMGN1
ITCH
KAT2B
MAFF
MAFG
MAFK
MAPK8
NEDD4
NFE2L2
NFE2L3
PEX14
PHYHIP
SCAND1
SSX5
TXN
UBE2I
WWP1
YAP1
43 interacting genes:
ACTN1
ACTN4
ANKRD11
APEX1
C1QA
C4BPA
CDKN1A
CEBPA
CFP
COL1A1
COPS5
DDIT4L
DNAJA1
DYNLT1
EGFR
ERBB2
ERBB3
ERBB4
FNDC3B
FST
GFER
GPRASP2
MAP3K5
MLH1
MRFAP1
MYD88
NCF4
NFE2
NFKB1
NIF3L1
NR3C1
NUP62
PTEN
SERTAD3
SIAH1
SPG21
SRPK2
TEX13A
TP53
TRAF2
TXNIP
UCHL5
VIM
Entrez ID
4778
7295
HPRD ID
09030
01761
Ensembl ID
ENSG00000123405
ENSG00000136810
Uniprot IDs
A8K3E0
Q16621
H9ZYJ2
P10599
PDB IDs
2KZ5
1AIU
1AUC
1CQG
1CQH
1ERT
1ERU
1ERV
1ERW
1M7T
1MDI
1MDJ
1MDK
1TRS
1TRU
1TRV
1TRW
2HSH
2HXK
2IFQ
2IIY
3E3E
3KD0
3M9J
3M9K
3QFA
3QFB
3TRX
4LL1
4LL4
4OO4
4OO5
4POK
4POL
4POM
4PUF
4TRX
5DQY
Enriched GO Terms of Interacting Partners
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Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
RNA Polymerase II Transcription Regulator Complex
Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Nucleus
Chromatin
Post-translational Protein Modification
Positive Regulation Of RNA Metabolic Process
Cellular Response To Nutrient Levels
Response To Radiation
Response To UV
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
N-terminal Peptidyl-lysine Acetylation
Ubiquitin-dependent Protein Catabolic Process
Response To Oxidative Stress
Modification-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Oxidative Stress
Cellular Response To Stress
DNA-binding Transcription Factor Activity
Integrated Stress Response Signaling
Rhythmic Process
Protein Modification Process
Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of Metabolic Process
Protein Modification By Small Protein Conjugation
Cellular Response To Chemical Stress
Positive Regulation Of Macromolecule Biosynthetic Process
Response To Nutrient Levels
Positive Regulation Of Biosynthetic Process
Protein Monoubiquitination
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Programmed Cell Death
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Apoptotic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Identical Protein Binding
Regulation Of RNA Metabolic Process
Intracellular Signaling Cassette
Regulation Of Primary Metabolic Process
Response To Epidermal Growth Factor
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Cellular Developmental Process
Regulation Of Gene Expression
ERBB2 Signaling Pathway
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Epidermal Growth Factor Receptor Signaling Pathway
Response To Stress
ERBB Signaling Pathway
Cytoplasm
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Intracellular Signal Transduction
Regulation Of Metabolic Process
Positive Regulation Of Signal Transduction
Cell Differentiation
Cellular Response To Epidermal Growth Factor Stimulus
ERBB3:ERBB2 Complex
Positive Regulation Of Programmed Cell Death
Glial Cell Differentiation
Ubiquitin Protein Ligase Binding
Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway
Response To Growth Factor
Positive Regulation Of Cell Communication
Positive Regulation Of Intracellular Signal Transduction
Signal Transduction
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Signaling
Epidermal Growth Factor Receptor Activity
Neuregulin Receptor Activity
Cellular Senescence
Programmed Necrotic Cell Death
Positive Regulation Of MiRNA Metabolic Process
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Tagcloud (Intersection)
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