NFE2 and NFE2L3

Number of citations of the paper that reports this interaction (PMID 23661758)
2

Data Source:
BioGRID (fluorescent resonance energy transfer, fluorescent resonance energy transfer)

		NFE2	NFE2L3
Gene Name		nuclear factor, erythroid 2	nuclear factor, erythroid 2-like 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Actin Cytoskeleton PML Body	Nucleus
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Sequence-specific DNA Binding Protein N-terminus Binding WW Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity
	Biological Process	Nucleosome Disassembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell-cell Signaling Multicellular Organismal Development Blood Coagulation Hemostasis Blood Circulation Negative Regulation Of Bone Mineralization Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Transcription, DNA-templated Labyrinthine Layer Blood Vessel Development Positive Regulation Of Peptidyl-lysine Acetylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419)	Body mass index ( 23583978) Obesity-related traits ( 23251661) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		21 interactors: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP SCAND1 SSX5 TXN WWP1 YAP1	9 interactors: BACH2 CREB3 MAFF MAFG MAFK NFE2 NFE2L1 NFE2L2 PPARG
Entrez ID		4778	9603
HPRD ID		09030	09162
Ensembl ID		ENSG00000123405	ENSG00000050344
Uniprot IDs		A8K3E0 Q16621	Q9Y4A8
PDB IDs		1LVX 2KZ5
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Viral Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Cellular Response To Oxidative Stress Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Response To Radiation N-terminal Protein Amino Acid Acetylation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Modification-dependent Protein Catabolic Process Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Gene Expression	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Nitrogen Compound Metabolic Process Blood Coagulation Hemostasis Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Response To Wounding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Epidermal Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Epidermis Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Metformin Response To Diuretic Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Negative Regulation Of Pancreatic Stellate Cell Proliferation Cellular Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Negative Regulation Of Intrinsic Apoptotic Signaling Pathway ER-nucleus Signaling Pathway In Utero Embryonic Development Cellular Response To Topologically Incorrect Protein Cellular Response To Vitamin E Regulation Of Cholesterol Transporter Activity Release From Viral Latency
Tagcloud ?		bear bzip cdna cnc construct designated exert functionally globin heterodimers hmaf homodimerize homodimers k562 kilobase lacks leucine library maf nrf1 nrf2 opposite p45 pair probe recognizable repeat tandem zipper	ago attracted basic biology bzip cap carcinogenesis cinderella cnc collar come contrary erythroid extensively fascinating homolog importantly insights leucine linking nevertheless newer nrf2 nrf3 overview shed subcellular zipper
Tagcloud (Difference) ?		bear cdna construct designated exert functionally globin heterodimers hmaf homodimerize homodimers k562 kilobase lacks library maf nrf1 opposite p45 pair probe recognizable repeat tandem	ago attracted basic biology cap carcinogenesis cinderella collar come contrary erythroid extensively fascinating homolog importantly insights linking nevertheless newer nrf3 overview shed subcellular
Tagcloud (Intersection) ?		bzip cnc leucine nrf2 zipper