NFE2 and PHYHIP

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		NFE2	PHYHIP
Gene Name		nuclear factor, erythroid 2	phytanoyl-CoA 2-hydroxylase interacting protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Actin Cytoskeleton PML Body
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Sequence-specific DNA Binding Protein N-terminus Binding WW Domain Binding
	Biological Process	Nucleosome Disassembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell-cell Signaling Multicellular Organismal Development Blood Coagulation Hemostasis Blood Circulation Negative Regulation Of Bone Mineralization Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Transcription, DNA-templated Labyrinthine Layer Blood Vessel Development Positive Regulation Of Peptidyl-lysine Acetylation
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419)	Hypertriglyceridemia ( 23505323)
Protein-Protein Interactions		21 interactors: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP SCAND1 SSX5 TXN WWP1 YAP1	24 interactors: BAI1 C14orf1 COPS6 DYRK1A EEF1A1 FAM131A HDAC11 HNRNPA1 MAGED4B MED8 METTL18 NDRG1 NDUFV3 NFE2 PHYH PNPLA2 PPIE PRMT5 S100A13 SMARCC2 SUPT5H TTR WDR89 ZZEF1
Entrez ID		4778	9796
HPRD ID		09030	16345
Ensembl ID		ENSG00000123405	ENSG00000168490
Uniprot IDs		A8K3E0 Q16621	Q92561
PDB IDs		1LVX 2KZ5
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Viral Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Cellular Response To Oxidative Stress Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Response To Radiation N-terminal Protein Amino Acid Acetylation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Modification-dependent Protein Catabolic Process Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Gene Expression	Nucleosome Disassembly Chromatin Organization Mast Cell Activation MRNA Processing RNA Metabolic Process Cellular Metabolic Process MRNA Metabolic Process MRNA Splicing, Via Spliceosome Interleukin-1 Alpha Secretion RNA Splicing, Via Transesterification Reactions Gene Expression RNA Processing Chromosome Organization Chromatin Modification Positive Regulation Of Viral Process Nucleobase-containing Compound Metabolic Process Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Methyl-branched Fatty Acid Metabolic Process Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Splicing Glial Cell Development Peripheral Nervous System Development Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Involved In Forebrain Neuron Fate Commitment Acylglycerol Acyl-chain Remodeling Thyroid Hormone Transport Isoprenoid Metabolic Process Fatty Acid Alpha-oxidation Interleukin-1 Secretion Positive Regulation Of Spindle Checkpoint Regulation Of RNA Metabolic Process
Tagcloud ?		bear bzip cdna cnc construct designated exert functionally globin heterodimers hmaf homodimerize homodimers k562 kilobase lacks leucine library maf nrf1 nrf2 opposite p45 pair probe recognizable repeat tandem zipper
Tagcloud (Difference) ?		bear bzip cdna cnc construct designated exert functionally globin heterodimers hmaf homodimerize homodimers k562 kilobase lacks leucine library maf nrf1 nrf2 opposite p45 pair probe recognizable repeat tandem zipper
Tagcloud (Intersection) ?